HPLC–based methods for the determination of levetiracetam in biological and pharmaceutical samples

Özbek, Oğuz; Berkel, Çağlar; Işıldak, Ömer; Gürdere, Meliha Burcu

doi:10.1016/j.jics.2022.100348

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…The linear relation between peak current and LEV concentration is expressed in the following Eq. ( 10), I p = 0.0392C + 0.4658, R 2 = 0.9938 (10) The value of LOD and LOQ for the proposed SWSV method was evaluated by employing the following relations, LOD = , (11) LOQ = (12) Where S denotes the standard deviation of peak current values and M refers to the slope of the calibration plots. The reported values of LOD (Eq.…”

Section: Determination Of Surface Coverage (γ O ) and Diffusion Coe C...mentioning

confidence: 99%

“…Various analytical methods are reported in the literature for the quantitative and qualitative determination of LEV in pure, medicinal dosage, and tablet form including spectrophotometry [8], gas chromatography (GC) [9], high-performance liquid chromatography (HPLC) [10], liquid chromatography-mass spectrometry (LC-MS) [11], HPLC-electro spray tandem mass spectrometry (HPLC-ESI-MS) [12], spectro-uorimetry [13] and capillary electrophoresis [14].…”

Section: Introductionmentioning

confidence: 99%

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Development of MoS2 flower-adorned pencil graphite electrode for electro-kinetic investigations and voltammetric quantification of anti-epileptic drug levetiracetam

Agarwal,

Jhankal,

Yadav

et al. 2023

J Appl Electrochem

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The fast, accurate, and affordable determination of anti-epileptic drug levetiracetam (LEV) is the need of time for human health. In this study, an electrochemical sensor platform was proposed for the costeffective and sensitive determination of the levetiracetam based on molybdenum sul de nano-owers adorned pencil graphite electrode (MoS 2 /PGE). The nano-owers of MoS 2 were prepared by a costeffective one-step facile hydrothermal method and the morphology of synthesized MoS 2 micro-owers was characterized via FESEM, XRD, and EDS techniques. Under the optimized experimental conditions, cyclic, linear sweep, and square wave voltammograms of LEV were recorded. The diffusion-controlled electrochemical oxidation of LEV produced one well-de ned irreversible peak in all voltammograms. The various electro-kinetics parameters like diffusion coe cient (D o =1.41×10 − 5 cm 2 s − 1 ), heterogeneous rate constant (K h =9.04×10 − 4 cms − 1 ), electron transfer coe cient (α = 0.66), the surface area of the fabricated electrode (A = 0.0767 cm 2 ) and surface coverage (Γ o = 2.98×10 − 11 molcm − 2 ) were evaluated for the oxidation of LEV at MoS 2 /PGE. The square wave stripping voltammetry (SWSV) method was optimized for the quanti cation of LEV in pharmaceutical samples. The oxidative peak current in SWSV methods varies linearly with LEV concentration within the range 72.0 to 130.0 µmolL − 1 with detection limit (LOD) value of 14.20 µmolL − 1 . The proposed MoS 2 /PGE platform provides a sensitive, low cost and ecofriendly tool for the rapid detection of LEV in clinical samples.

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Section: Determination Of Surface Coverage (γ O ) and Diffusion Coe C...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of MoS2 flower-adorned pencil graphite electrode for electro-kinetic investigations and voltammetric quantification of anti-epileptic drug levetiracetam

Agarwal,

Jhankal,

Yadav

et al. 2023

J Appl Electrochem

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“…The least square method is employed for the determination of linearity. 17 Precision Six tablets of ropinirole and levetiracetam were subjected to a dissolution test for repeatability on the same day and two different days. Different HPLC instrument (Agilent 1200 series LC system) is also used for the determination of precision.…”

Section: Specificitymentioning

confidence: 99%

A Correlative Dissolution Study of Oral Drug Delivery Systems through Reverse Phase-HPLC Analysis

Poongothai,

Srinivasan,

Rama

2023

IJPQA

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Oral drug administration is essential for treating diverse diseases due to its acceptable route, non-invasiveness, minimal off-target side effects, versatility, and painless patient delivery. However, multiple drug accessibility is increasing currently but there is often a deficiency of indication in developing procedures with assessment of two diverse medicinal formulations. Oral administration of a novel antiepileptic drug, levetiracetam in grouping with either L-dopa unaccompanied or L-dopa/Ropinirole treatments was associated with dyskinesia. Altered shooting patterns of neurons relating to a compulsive harmonization process may back to the origin of dyskinesia. The current study aims to develop a dissolution technique and validate the antiparkinsonian drug-ropinirole and antiepileptic drug-levetiracetam tablets by RP-HPLC, which plays a major part in pharmaceutical formulations. The optimal dissolution conditions were experienced for the products respective to the pharmaceutical formulation and applied to assess the dissolution profiles. Ideal settings for the dissolution method were 500 mL of pH of 4.0 citrate buffer, 50 rpm and 250 nm for ropinirole tablets and 900 mL of distilled water, the rotation speed of paddle 50 rpm and 217 nm for levetiracetam tablets, then 3.84 and 3.87 minutes were set as the retention time of ropinirole and levetiracetam tablets, respectively. Technique optimization and validation process helps to reduce the bioequivalence of both dosage forms. The current study ensues detailed information on the drug release, even if there is a change in pH medium, filter, rpm, instrumentation, etc. Focusing on current pharmaceutical sciences, the proposed correlative dissolution study coupled with RP-HPLC analysis could offer a holistic insight into the performance of future oral drug delivery systems

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Titania-based fabric phase sorptive extraction approach for the determination of antiepileptic drugs, levetiracetam and lamotrigine in urine samples using high-performance liquid chromatography-photo diode array detection

Ulusoy,

Locatelli

et al. 2024

Journal of Chromatography A

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HPLC–based methods for the determination of levetiracetam in biological and pharmaceutical samples

Cited by 6 publications

References 39 publications

Development of MoS2 flower-adorned pencil graphite electrode for electro-kinetic investigations and voltammetric quantification of anti-epileptic drug levetiracetam

Development of MoS2 flower-adorned pencil graphite electrode for electro-kinetic investigations and voltammetric quantification of anti-epileptic drug levetiracetam

A Correlative Dissolution Study of Oral Drug Delivery Systems through Reverse Phase-HPLC Analysis

Titania-based fabric phase sorptive extraction approach for the determination of antiepileptic drugs, levetiracetam and lamotrigine in urine samples using high-performance liquid chromatography-photo diode array detection

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