HPLC-DAD profiling, enzyme inhibitory, antihemolytic, and photoprotective activities of Limonium delicatulum leaf extract

Bakhouche, Imene; Boubellouta, Tahar; Aliat, Toufik; Gali, Lynda; Bellik, Yuva

doi:10.1016/j.bcab.2022.102438

Cited by 2 publications

(4 citation statements)

References 34 publications

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“…In addition, 3,4-dihydroxy-5-methoxybenzoic acid and 7-hydroxycoumarin-3-carboxylic acid compounds were recently identified in L. delicatulum leaf extracts. [32] Here, the most abundant component identified in L. tunetanum Barratte & Bonnet) Maire MeOH fraction was the L-tyrosine 7-amido-4methylcoumarin with the amount of 20.8 mg/g of dr, whereas gallic acid was the highest one in L. pruinosum Kuntze with 15.9 mg/g of dr. Gallic acid (10.5 mg/g) and 2.4-dihydroxy-3.6dimethylbenzoic acid (6.1 mg/g) were the major compounds identified in the EtOAc extracts of L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire, respectively (Table 2). The apolar compounds distribution showed that the 5-hydroxy-3'methoxyflavone compound was mostly accumulated in the CYHA of L. pruinosum Kuntze with 10.1 mg/g, while, the pinosylvin monomethyl ether was found in L. tunetanum (Barratte & Bonnet) Maire ones with the an amount of 1.1 mg/g (Table 2).…”

Section: Hplc Analysis Of Limonium Species Extractsmentioning

confidence: 75%

“…Furthermore, Mahmoudi et al [31] identified several phenolic compounds in the L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire extract, such as, gallic acid among them. In addition, 3,4‐dihydroxy‐5‐methoxybenzoic acid and 7‐hydroxycoumarin‐3‐carboxylic acid compounds were recently identified in L. delicatulum leaf extracts [32] . Here, the most abundant component identified in L. tunetanum Barratte & Bonnet) Maire MeOH fraction was the L‐tyrosine 7‐amido‐4‐methylcoumarin with the amount of 20.8 mg/g of dr, whereas gallic acid was the highest one in L. pruinosum Kuntze with 15.9 mg/g of dr. Gallic acid (10.5 mg/g) and 2.4‐dihydroxy‐3.6‐dimethylbenzoic acid (6.1 mg/g) were the major compounds identified in the EtOAc extracts of L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire, respectively (Table 2).…”

Section: Resultsmentioning

confidence: 99%

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Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Rahmani,

Debouba,

Aydi

et al. 2023

Chemistry & Biodiversity

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Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in L. tunetanum compared to L. pruinosum. HPLC‐DAD analysis showed that distinctly the gallic acid and L‐tyrosine 7‐amido‐4‐methylcoumarin were the main compounds for L. pruinosum and L. tunetanum, respectively. For both Limonium. Mil species, the MeOH extracts displayed the highest antioxidant with IC50 of 7.7 and 8.4 μg/mL for L. pruinosum and L. tunetanum, respectively. The highest anti‐15‐lipoxygnase activity was recorded in the ethyl acetate (IC50=14.2 μg/mL) and Methanol (IC50=15.6 μg/mL) extracts for L. pruinosum. However, for L. tunetanum the best activity was recorded for dichloromethane extract (IC50=10.4 μg/mL). L. pruinosum extracts displayed the highest cytotoxic activity against MCF‐7 and HCT‐116 cell lines compared to L. tunetanum ones. The obtained bioactivity discrepancy between Limonium. Mill species was discussed in relation to the organic extract chemical richness.

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Section: Hplc Analysis Of Limonium Species Extractsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Rahmani,

Debouba,

Aydi

et al. 2023

Chemistry & Biodiversity

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“…The main components found in the extracts were salicylic and gentisic acids [49]. Finally, methanol extracts from L. delicatulum leaves demonstrated efficacy against AChE and BuChE (EC 50 = 5.94 and 11.68 µg/mL, respectively), with salvianolic acid B and polydatin recognised as predominant active constituents [50]. In general, these examples showcase the various bioactive compounds and neuroprotective abilities linked to plants that can thrive in salty conditions.…”

Section: In Vitro Assaysmentioning

confidence: 85%

“…and Limonium sp. have been the focus of multiple studies, indicating their significance in the context of neuroprotection [32,33,42,[47][48][49][50]. For instance, Salicornia europaea (L.) is a species from the family Chenopodiaceae, and it has been the subject of several investigations.…”

Section: In Vitro Assaysmentioning

confidence: 99%

Neuroprotective and Mental Health Benefits of Salt-Tolerant Plants: A Comprehensive Review of Traditional Uses and Biological Properties

Rodrigues,

Pereira,

Custódio

2024

Applied Sciences

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This study undertakes a thorough review of the ethnomedicinal properties of salt-tolerant plants and their potential to treat neurological disorders and enhance mental health. Aimed at bridging the gap between historical knowledge and contemporary scientific validation, our research meticulously evaluates both the traditional uses and the existing scientific evidence supporting the neuroprotective effects of these plants, leveraging in vitro and in vivo experimental findings. Through a comprehensive search of articles from 2001 to December 2023 across scientific databases, we identified sixteen species across nine plant families with demonstrated in vitro neuroprotective properties. Among these, the Chenopodiaceae and Juncaceae families emerged as the most represented, including plants such as Salicornia sp., Juncus sp., and Limonium sp., primarily recognized for their cholinesterase inhibitory activity. However, a notable disparity exists between traditional applications and scientific examination, with only six species undergoing in vivo testing. This discrepancy underscores the imperative for future research to delve deeper into validating traditional uses and elucidating the mechanisms underlying neuroprotection. Our findings highlight the need for research on salt-tolerant plants traditionally used for neurological benefits. Key steps include systematic screening, identification of active compounds through bioassay-guided fractionation, and in vivo testing. Integrating traditional knowledge with modern pharmacology, while emphasizing sustainable and ethical approaches, is essential for advancing neuroprotective drug discovery.

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HPLC-DAD profiling, enzyme inhibitory, antihemolytic, and photoprotective activities of Limonium delicatulum leaf extract

Cited by 2 publications

References 34 publications

Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Neuroprotective and Mental Health Benefits of Salt-Tolerant Plants: A Comprehensive Review of Traditional Uses and Biological Properties

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