HPLC determination of sulfamethazine in milk using surface-imprinted silica synthesized with iniferter technique

Synthesis and characterization of the core–shell magnetic molecularly imprinted polymers (Fe3O4@MIPs) adsorbents for effective extraction and determination of sulfonamides in the poultry feed

“…In comparison with antibodies, enzymes or biological receptors, MIPs show inherent advantages: their production is quite simple and economical, moreover the polymers show good physical and chemical stability and applicability in harsh chemical media without loss of binding properties. In recent years, several MIPs for sulfamethoxazole [19][20][21][22][23] and sulfamethazine [22][23][24][25][26][27][28] have been prepared as the stationary phase for HPLC and as solid-phase extracting agents, but few published articles has focused on analysis of sulfonamides in fish, pork, chicken and milk samples using methods based on MIP technology. Most MIPs for sulfonamides have been synthesized in bulk polymerization, followed by a grinding and sieving process to acquire the desired particles; these can suffer from drawbacks in some applications, for example, heterogeneous distribution of the binding sites, poor site accessibility to the target molecules because the template and functionality are totally embedded in the polymer matrices.…”

Surface Imprinting of Silica Gel by Methyldopa and Its Application in the Solid Phase Extraction Procedure

“…The choice of interferents was also based on their affinity for the surface imprinted silica and the effect on the analytical signal of MTD measured by UV-Vis spectrophotometry. In the presence of the excess of uric acid, glucose, sucrose, PO 4 3-, CO 3 2-, SO 4 2-, NO 3 -, Cl − , Fe 3+ , Mg 2+ , Ca 2+ , Na + and K + , the relative absorbance of MTD was in the range of about 90-97% compared with the standard solution of MTD. The interfering substances were added separately in the concentration range of 1-50000 µg mL -1 to the MTD solution (70 µg mL -1 ) and extraction procedure was used.…”

“…2,3 Recently, MIPs, as highly selective solid adsorbents, have been widely used in various fields, such as separation and preconcentration, manufacturing of sensors, the stationary phases for chromatography, pseudo immunoassay, catalysis and others. [2][3][4][5][6][7][8][9] In particular, new method of molecularly imprinted solid phase extraction (SPE), in which the MIP-solid adsorbent can selectively extract, has attracted much attention in the separation and enrichment area. 6,[10][11][12] The usual method for preparing MIPs, the entrapping way, has some disadvantages, such as time-consuming and complicated preparation method, less recognition sites within the matrix polymer particles obtained by crushing and grinding imprinted polymeric monolith, and greater diffuse barrier for the template molecules coming from matrix thickness, resulting in poor binding capacity and lower binding kinetics of MIPs to the template molecule.…”

Molecularly imprinted beads with double thermosensitive gates for selective recognition of proteins

“…The amount of polymer grafted on to the MCP beads, which may affect the imprinting effect of the MIP, is the function of the reaction rate and the time of polymerization [32]. The reaction rate is affected by the concentration of initiator, the light intensity, and the concentration of monomers [33]. To produce MIP beads with an ideal imprinting effect, the effect of the concentration of monomers was investigated when the concentration of the initiator and the light intensity were fixed.…”