HPLC Method Validation for Determination of Pentoxifylline in Pharmaceutical Dosage Forms

Thalaj, Nasser

doi:10.54105/ijac.c2012.041322

IJAC

2022

DOI: 10.54105/ijac.c2012.041322

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HPLC Method Validation for Determination of Pentoxifylline in Pharmaceutical Dosage Forms

Nasser Thalaj¹

Abstract: A selective and simple reversed phase High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for quantification of pentoxifylline in dosage forms available in local market. Firstly, different chromatographic conditions were tested. Then, the optimized method was validated. The method proven to be linear over 50% to 150% of the nominal concentration of standard pentoxifylline (R2 0.994). The method was accurate (recovery 100.1%) and precise (RSD% <3%). The method could separate p… Show more

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Cited by 4 publications

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“…and 2.312(7) Å) figure11 [23]. Figure11Chapitre 1In complex 46, the iron atom is bonded to 6 oxygen atoms, the shortest bonds bei se to the phenolic O atoms (Fe ... O 1.802(8) and 1.830(7) Å), the next longest bei bonds to the carbonyl oxygens (2.058(7) and 2.031(7) Å), the longest being those etheral oxygen atoms (2.230(7) and 2.312(7) Å) 23. …”

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confidence: 99%

Review of Calixarene-Derivatives in Transition Metal Chemistry

Thallaj¹

2022

IJAPSR

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The survey depicts the combination of large-scale monodentate phosphites in response to PCl3/NEt3 with p-tert-butyl calix[4]-(OH)3-OR, where R contains an oxygen-containing substituent (R = CH2P(O)Ph2, -CH2CO2Et, -CH2C(O)NEt2, -CH2CH2OMe). These funnel-shaped calissarenes have a phosphorus particle bridging three phenolic oxygen atoms, and are incredibly steady in NaOH-aqueous arrangement due to the cone point being more noteworthy than 180°. Upon response with transition metal particles, these phosphites shape either P monodentate complexes or expansive P,O chelate complexes including the oxygen atom of the R group. The reactivity of four different ligands in the rhodium-catalyzed hydroformylation of octene was examined. The general trend is that a bulkier phosphite ligand leads to a slower reaction rate. The ligand-to-base ratios ranged from 1.4 to 3.6, and the highest straight aldehyde selectivity was observed when the carboxylate group was CH2CO2Et.

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confidence: 99%

Review of Calixarene-Derivatives in Transition Metal Chemistry

Thallaj¹

2022

IJAPSR

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Eco-friendly RP-HPLC approach for simultaneously estimating the promising combination of pentoxifylline and simvastatin in therapeutic potential for breast cancer: Appraisal of greenness, whiteness, and Box–Behnken design

Mahgoub,

Alwaili,

Rudayni

et al. 2024

Green Processing and Synthesis

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Breast cancer affects millions of women worldwide. This study explores the potential of combining pentoxifylline (PTX) and simvastatin (SIM) as a treatment for breast cancer. We aimed to develop six sustainability tools using green and white metrics to evaluate the environmental impact of reversed-phase high-performance liquid chromatography (RP-HPLC) methods for analyzing and separating PTX and SIM in their pure forms. The tools include analytical GREEnness, green analytical procedure index, Complexgreen analytical procedure index, analytical greenness metric for sample preparation, blue applicability grade index, and the RGB 12 algorithm. For the separation, we used a Novapack C8 column (15 × 0.46 cm, 5 µm) at 25°C. The injection volume was 5.0 µL, the wavelength was set to 210 nm, and the total runtime was 5 min. We identified optimal chromatographic conditions efficiently using the Box–Behnken design with minimal trials. We investigated the effects of three factors on retention time and resolution: acetonitrile ratio, pH, and flow rate. We used overlay plots with a 60:40 ratio (v/v) of acetonitrile and bi-distilled water to forecast the most effective mobile phase. The calibration curves for PTX and SIM showed a correlation value of over 0.999 within the range of 5–60 µg·mL−1. The recovery rates ranged from 99.9% to 100.2%, indicating high accuracy. Our RP-HPLC technique proves to be reliable and efficient for the simultaneous estimation of multiple anticancer drugs. We evaluated the environmental sustainability of this approach using green and white metrics, and the recommended method has been thoroughly validated according to International Council for Harmonisation guidelines, making it highly reliable for analyzing new formulations.

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Microwave-Assisted Synthesis of Oxadiazole and Thiazolidine Derivatives

Thallaj¹

2022

IJAC

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1,3,4-oxadiazole derivatives constitute a group of biologically important compounds that have been used as analgesic, anti-inflammatory, antibacterial, antifungal, antispasmodic, or psychotropic drugs in addition to their role in plant growth regulation and monoamine oxidase inhibition. This study focused on the use of microwaves in the synthesis of oxadiazole derivatives containing thiazolidinediones, which are promising for use as new drugs. For the first time, thiazolidinediones were synthesized by reacting benzaldehyde with cysteine with very good yield using microwave radiation at 340 watt. Subsequently, thiazolidine hydrazide (L3) was synthesized, which was reacted with carboxylic acid or carbon disulfide to be obtained in the presence of a base oxadiazole derivatives L4, L5, L6, L7, L8. The subjectivity of the synthetic compounds was verified by melting point measurement, E. Analy, and analysis using thin layer chromatography (TLC), FT-IR, mass spectrometry (EI-MS), and NMR spectroscopy.

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HPLC Method Validation for Determination of Pentoxifylline in Pharmaceutical Dosage Forms

Cited by 4 publications

References 34 publications

Review of Calixarene-Derivatives in Transition Metal Chemistry

Review of Calixarene-Derivatives in Transition Metal Chemistry

Eco-friendly RP-HPLC approach for simultaneously estimating the promising combination of pentoxifylline and simvastatin in therapeutic potential for breast cancer: Appraisal of greenness, whiteness, and Box–Behnken design

Microwave-Assisted Synthesis of Oxadiazole and Thiazolidine Derivatives

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