HPLC methods for quantifying anticancer drugs in human samples: A systematic review

Sabourian, Reyhaneh; Mirjalili, Seyedeh Zohreh; Namini, Negar; Chavoshy, Fateme; Hajimahmoodi, Mannan; Safavi, Maliheh

doi:10.1016/j.ab.2020.113891

Cited by 32 publications

(13 citation statements)

References 127 publications

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“…[9][10][11] As a result, advanced analytical approaches for sensitive 5-Fu concentration monitoring in pharmaceuticals and biological samples are still being developed. 12 For instance, methods such as HPLC Analysis, 13 uorescence, 14 electrochemical sensors, 15 AAS, 16 and chromatography methods 17 are used for the detection of 5-Fu at its concentration level. Regardless the approaches of previously discussed, electrochemical sensing has been identied as one of the best methods for quick response, greater sensitivity, selectivity, low cost, ease to handle, etc.…”

Section: Introductionmentioning

confidence: 99%

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

et al. 2023

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Section: Introductionmentioning

confidence: 99%

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

et al. 2023

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“…Simultaneous determination of ENZ, N‐ desmethyl ENZ, abiraterone, and bicalutamide in human plasma using LC‐MS/MS [35], and UPLC‐MS/MS [36] were published. A review of HPLC methods for quantifying anticancer drugs in human samples was published [37]. Among the bio‐analytical methods mentioned, the LC‐MS/MS method [33] is more sensitive (lower LOQ: 0.5 ng/ml) and linear in the range of 0.5–1000 ng/ml, whereas LC‐MS/MS method [42] is more rapid (run time: 2.0 min).…”

Section: Bio‐analytical Methodsmentioning

confidence: 99%

Characteristics, properties, and analytical and bio‐analytical methods of enzalutamide: A review

Bondigalla¹,

Naidu

Yarraguntla³

et al. 2023

Separation Science Plus

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Enzalutamide is a potent second‐generation androgen receptor inhibitor that is used to treat metastatic castration‐resistant prostate cancer. It was developed by Medivation and Astellas and was approved by the Food and Drug Administration in 2012 under the brand name Xtandi. Enzalutamide has three major anticancer mechanisms, it inhibits the binding of androgens to the ligand‐binding domain of androgen receptors; inhibits nuclear translocation of androgen receptors; inhibits binding of androgen receptors to deoxyribonucleic acid. It demonstrates reduced expression of androgen receptor‐dependent genes, decreased prostate cancer cell proliferation, and induction of cancer cell death and tumor regression. As a result, patients with metastatic castration‐resistant prostate cancer have a higher chance of survival. Enzalutamide is very important in anticancer therapy, hence, it's necessary to compile all the analytical and bio‐analytical methods to monitor the bioequivalence, bioavailability, and therapeutic monitoring of a drug substance during the course of patient follow‐ups. Thus, this study presents a comprehensive review of the literature on characteristics, properties, and analytical and bio‐analytical methods in various matrices, including formulations, biological fluids, and drug delivery systems.

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“…In recent years, the expansion of the scientific research in the area of drug determination in human fluids highlights the importance of this issue. [3,4] Bicalutamide (BLT) is a non-steroidal anti-androgen which is most widely used to reduce tumor symptoms in the patients with metastatic prostate cancer. BLT is usually used 150 mg per day either alone or as adjuvant by the patients in clinical treatments.…”

Section: Introductionmentioning

confidence: 99%

Near‐infrared light responsive dendrimers facilitate the extraction of bicalutamide from human plasma and urine

Mahdavijalal

Panahi

Ниази

et al. 2021

Biotechnology Journal

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Background: Today, it is well accepted that the quantitative measurement of anticancer drugs in human biological samples requires the development and validation of efficient bioanalytical methods. This study attempts to provide a high-capacity and thermo-sensitive nano-adsorbent for bicalutamide extraction from human biological fluids. Main Methods and Major Results:In this study, five generations of thermo-sensitive dendrimers were synthesized onto the surface of WS 2 nano-sheets. After drug-loading process from body fluids, the near-infrared (NIR) light (at 808 nm) was applied and light-to-heat conversion by the WS 2 nano-sheets led to shrinkage in polymer chains, resulting the release of the entrapped drug. Finally, the extracted drug was analyzed via HPLC-UV system (at 270 nm). The final nano-adsorbent was described via FE-SEM, XRD, FT-IR, and TGA techniques. The adsorption isotherm data were well fitted by Langmuier isotherm model (R 2 = 0.9978). The mean recoveries for spiking bicalutamide at three different concentrations in plasma and urine samples were 92.12% and 94.54% under the NIR light irradiation. Conclusions and Implications:We have developed a smart strategy to analyze bicalutamide in biological samples using near-infrared light irradiation in a controlled manner. All the results indicate the promising application of the proposed method for the extraction and determination of bicalutamide.

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HPLC methods for quantifying anticancer drugs in human samples: A systematic review

Cited by 32 publications

References 127 publications

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

In situsynthesis of polythiophene encapsulated 2D hexagonal boron nitride nanocomposite based electrochemical transducer for detection of 5-fluorouracil with high selectivity

Characteristics, properties, and analytical and bio‐analytical methods of enzalutamide: A review

Near‐infrared light responsive dendrimers facilitate the extraction of bicalutamide from human plasma and urine

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