hPSC-derived lung organoids: Potential opportunities and challenges

Du, Xiaohong; Dong, Yongpin; Li, Wenfang; Chen, Yong

doi:10.1016/j.heliyon.2023.e13498

Cited by 2 publications

(1 citation statement)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future research will necessitate incorporating additional cell types from the tumor microenvironment, such as immune cells, stromal cells, or neural cells, into organoid cultures. This approach aims to create a more accurate representation of the tumor environment [ 60 ].…”

Section: Limitationsmentioning

confidence: 99%

The potential of organoids in renal cell carcinoma research

Chen,

Sun,

et al. 2024

BMC Urol

View full text Add to dashboard Cite

Renal cell carcinoma, a leading cause of death in urological malignancies, arises from the nephron. Its characteristics include diversity in disease biology, varied clinical behaviors, different prognoses, and diverse responses to systemic therapies. The term ‘organoids’ is used to describe structures resembling tissues created through the three-dimensional cultivation of stem cells in vitro. These organoids, when derived from tumor tissues, can retain the diversity of the primary tumor, mirror its spatial tissue structure, and replicate similar organ-like functions. In contrast to conventional two-dimensional cell cultures and the transplantation of tumor tissues into other organisms, organoids derived from tumors maintain the complexity and microenvironment of the original tumor tissue. This fidelity makes them a more reliable model for the development of cancer drugs, potentially accelerating the translation of these drugs to clinical use and facilitating personalized treatment options for patients. This review aims to summarize the recent advancements in the use of organoids for studying renal cell carcinoma, focusing on their cultivation, potential applications, and inherent limitations.

show abstract

Section: Limitationsmentioning

confidence: 99%

The potential of organoids in renal cell carcinoma research

Chen,

Sun,

et al. 2024

BMC Urol

View full text Add to dashboard Cite

show abstract

Organoids in virology

Chu,

Lamers

2024

npj Viruses

View full text Add to dashboard Cite

To adequately prepare against imminent disease outbreaks from diverse and ever-changing viral pathogens, improved experimental models that can accurately recapitulate host-virus responses and disease pathogenesis in human are essential. Organoid platforms have emerged in recent years as amenable in vitro tools that can bridge the limitations of traditional 2D cell lines and animal models for viral disease research. We highlight in this review the key insights that have contributed by organoid models to virus research, the limitations that exist in current platforms, and outline novel approaches that are being applied to address these shortcomings.

show abstract

hPSC-derived lung organoids: Potential opportunities and challenges

Cited by 2 publications

References 71 publications

The potential of organoids in renal cell carcinoma research

The potential of organoids in renal cell carcinoma research

Organoids in virology

Contact Info

Product

Resources

About