HPTLC method development and validation for simultaneous estimation of Metoprolol Succinate and Felodipine in bulk drugs and combined dosage forms.

Rao, Janhavi R

doi:10.22376/ijpbs.2018.9.2.p1-7

Cited by 1 publication

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A literature survey revealed that several HPLC [7][8][9][10][11][12][13][14][15] , SFC. [16] References [17][18] are helpful in performing validation properly and HPTLC in combination reported [19][20] but no HPTLC method reported for stability study of FEP. Therefore, it was thought of interest to develop simple, rapid, accurate, specific and precise HPTLC method for the analysis of felodipine (FEP) in its tablet formulation.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Stability Indicating Assay Method for Determination of Felodipine in Tablet Dosage Form

Patre

Patil

2018

Int. J. Pharm. Sci. Drug Res.

View full text Add to dashboard Cite

A simple and sensitive, HPTLC method has been developed for the quantitative estimation of felodipine in it’s single component tablet formulation. The separation was carried out on Merck aluminium plates precoated with silica Gel 60 F254 using n -hexane: ethyl acetate in the ratio of 6:4 (v/v) as mobile phase. Felodipine showed Rf value of 0.53 ± 0.027 and was scanned at 366 nm using Camag TLC Scanner 3. The linear regression data for the calibration plot showed a good relationship with r=0.9792. The method was validated for precision and recovery. The limits of detection and quantification were 23.54 and 71.33 ng/spot respectively. The developed method was successfully used for the assay of felodipine tablet formulations. The method is simple, sensitive and precise; it can be used for the routine quality control testing of marketed formulations.

show abstract