HPV-16 and HLA-DRB1 Alleles Are Associated with Cervical Carcinoma in Mexican Mestizo Women

Aláez-Verson, Carmen; Berumen, Jaime; Munguía-Saldaña, Andrea; Flores-Aguilar, Hilario; Guardado-Estrada, Mariano; Rodríguez-Gómez, A.; Gorodezky-Lauferman, Clara

doi:10.1016/j.arcmed.2011.07.002

Cited by 12 publications

(14 citation statements)

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“…Patients in the viral persistence group were considered cases to be contrasted against the other two groups (HPV-cleared and HPV-reinfected), as well as against a group of healthy Mexican women with a normal Papanicolaou smear (considered healthy individual controls, n = 88) described elsewhere [27], and against a group of Mexican women with CC (considered disease controls, n = 104) described elsewhere as well [26] (both were considered external controls). Since viral persistence has been directly associated with the development of premalignant lesions and CC, in order to search for possible associations of alleles with susceptibility or resistance to viral persistence and CC, we decided to compare our three study groups with the previously mentioned external control groups [26,27].…”

Section: Resultsmentioning

confidence: 99%

“…Since viral persistence has been directly associated with the development of premalignant lesions and CC, in order to search for possible associations of alleles with susceptibility or resistance to viral persistence and CC, we decided to compare our three study groups with the previously mentioned external control groups [26,27]. …”

Section: Resultsmentioning

confidence: 99%

“…The results for the healthy individual external control group [27], and those for the external disease control group [26], respectively, are described in the first and last columns of Table 3. The most frequent alleles of the former group were HLA- DRB1 *04, DRB1 *08 and DRB1 *14 with the first two being also the most frequent in the latter group.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, a recent report looking for the correlation of HPV-16 and CC in Mexican women, showed that DRB1 *04:03 influences the risk of developing HSIL, independently of HPV16 and DRB1 *01:01, it may confer protection against the development of CC. The HLA- DRB1 *04:07 allele was increased in HPV16 positive patients, confirming that the HLA association is HPV dependent [27]. …”

Section: Introductionmentioning

confidence: 85%

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HLA-DRB1 Class II antigen level alleles are associated with persistent HPV infection in Mexican women; a pilot study

Bernal‐Silva

Granados

Gorodezky³

et al. 2013

Infect Agents Cancer

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BackgroundPersistent infection with high-risk human papillomavirus (HPV) is a major risk factor for malignant lesions and cervical cancer. A widely studied element in the search for genetic factors influencing risk HPV infection diseases is allelic variation of the human leukocyte antigen (HLA) locus. The study was designed to search for HLA susceptibility alleles contributing to the persistence of HPV infection in Mexican women.MethodsA total of 172 subjects were divided into three groups: 1) HPV–persistent patients; 2) HPV–cleared; and 3) HPV–reinfected patients. They were screened for HPV types using a polymerase chain reaction (PCR). PCR-sequence specific oligonucleotide probes (PCR-SSOP) was used for HLA DRB1 and DQB1 typing.ResultsWe observed that HLA-DQB1*0501 allele might be associated with susceptibility of reinfection with HPV (p = 0.01, OR = 4.9, CI 95% = 1.3 -18.7). Allele frequency of HLA-DRB1*14 was particularly reduced in patients with cancer when compared with the HPV–persistent group (p = 0.04), suggesting that this allele is a possible protective factor for the development of cervical cancer (OR = 2.98). HLA-DRB1*07 might be associated with viral clearance (p = 0.04).ConclusionsGenetic markers for HPV infection susceptibility are different in each population, in Mexicans several HLA-DQB1 alleles might be associated with an enhanced risk for viral persistence. In contrast, DRB1*14, seems to confer protection against cervical cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 85%

See 2 more Smart Citations

HLA-DRB1 Class II antigen level alleles are associated with persistent HPV infection in Mexican women; a pilot study

Bernal‐Silva

Granados

Gorodezky³

et al. 2013

Infect Agents Cancer

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View full text Add to dashboard Cite

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“…Susceptibility to HPV infection or cervical cancer and precancerous lesion development was associated with the HLA class II: HLA-DRB1 alleles [34, 39–51]; HLA-DQB1 alleles [34, 39, 46, 49–51]; HLA-DPB1 alleles [51]; and classes I and II haplotypes [30, 34, 40–42, 48, 52, 53]. Some alleles and haplotypes had a protective effect against the progression to infection and cancer [34, 38–40, 43, 46, 47, 51, 54, 55]. In general, HLA-DQB1∗03 increases and DRB1∗13 decreases the risk of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Marangon

Guelsin

Visentainer

et al. 2013

BioMed Research International

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The genetic variability of the host contributes to the risk of human papillomavirus (HPV)-related cervical disease. Immune response genes to HPV must be investigated to define patients with the highest risk of developing malignant disease. The aim of this study was to investigate the association of polymorphic immune response genes, namely KIR, HLA class I and II, and single-nucleotide polymorphisms (SNPs) of cytokines with HPV-related cervical disease. We selected 79 non-related, admixed Brazilian women from the state of Paraná, southern region of Brazil, who were infected with high carcinogenic risk HPV and present cervical intraepithelial neoplasia grade 3 (CIN3), and 150 HPV-negative women from the same region matched for ethnicity. KIR genes were genotyped using an in-house PCR-SSP. HLA alleles were typed using a reverse sequence-specific oligonucleotide technique. SNPs of TNF −308G>A, IL6 −174G>C, IFNG +874T>A, TGFB1 +869T>C +915G>C, and IL10 −592C>A −819C>T −1082G>A were evaluated using PCR-SSP. The KIR genes were not associated with HPV, although some pairs of i(inhibitory)KIR-ligands occurred more frequently in patients, supporting a role for NK in detrimental chronic inflammatory and carcinogenesis. Some HLA haplotypes were associated with HPV. The associations of INFG and IL10 SNPs potentially reflect impaired or invalid responses in advanced lesions.

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Host genetic influence on papillomavirus‐induced tumors in the horse

Staiger

Tseng

Miller

et al. 2016

Intl Journal of Cancer

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The common equine skin tumors known as sarcoids have been causally associated with infection by bovine papillomavirus (BPV). Additionally, there is evidence for host genetic susceptibility to sarcoids. We investigated the genetic basis of susceptibility to sarcoid tumors on a cohort of 82 affected horses and 270 controls genotyped on a genome-wide platform and two custom panels. A Genome Wide Association Study (GWAS) identified candidate regions on six chromosomes. Bayesian probability analysis of the same dataset verified only the regions on equine chromosomes (ECA) 20 and 22. Fine mapping using custom-produced SNP arrays for ECA20 and ECA22 regions identified two marker loci with high levels of significance: SNP BIEC2-530826 (map position 32,787,619) on ECA20 in an intron of the DQA1 gene in the Major Histocompatibility Complex (MHC) class II region (p 5 4.6e-06), and SNP BIEC2-589604 (map position 25,951,536) on ECA22 in a 200 kb region containing four candidate genes: PROCR, EDEM2, EIF6 and MMP24 (p 5 2.14e-06). The marker loci yielded odds ratios of 5.05 and 4.02 for ECA20 and ECA22, respectively. Associations between genetic MHC class II variants and papillomavirus-induced tumors have been reported for human papillomavirus and cottontail rabbit papillomavirus infections. This suggests a common mechanism for susceptibility to tumor progression that may involve subversion of the host immune response. This study also identified a genomic region other than MHC that influenced papillomavirus-induced tumor development in the studied population.

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HPV-16 and HLA-DRB1 Alleles Are Associated with Cervical Carcinoma in Mexican Mestizo Women

Cited by 12 publications

References 14 publications

HLA-DRB1 Class II antigen level alleles are associated with persistent HPV infection in Mexican women; a pilot study

HLA-DRB1 Class II antigen level alleles are associated with persistent HPV infection in Mexican women; a pilot study

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Host genetic influence on papillomavirus‐induced tumors in the horse

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