Human papillomavirus infection (HPV) is one of the most common infections today. Young women have a high risk of infection with HPV. The contagiosity of the virus reaches 80%. HPV is a cause of cervical cancer. Genital warts is one of the most common clinical manifestations of HPV, the incidence is 120–150 per 100,000 population. The aim of the study was to assess the degree of incidence of vulvar and vaginal warts, according to the official statistical forms and clinical practice. The statistical forms do not give an accurate account of the incidence of HPV due to the characteristics of reporting. According to clinical observation, signs of HPV were detected in 23,3% of female students, who underwent periodic medical examinations, and in 10,1% of patients, who addressed complaints to the gynecologist. Inosine pranobex is the most studied systemic immunomodulator used to eliminate HPV. The non-intervention open-site single-center study showed that the effectiveness of monotherapy acounted for 66,9%, which categorized inosine pranobex as a first-line drug.