HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia

Abstract

Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention. Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical cancer. HPV genotyping has potentially valuable applications in triage of low-grade abnormal cervical cytology, assessment of prognosis and followup of cervical intraepithelial neoplasia, and in treatment strategies for invasive cervical cancer. It is known that during the development of cervical cancer associated with HPV infection, a cascade of abnormal events is induced, including disruption of cellular cycle control, alteration of gene expression, and deregulation of microRNA expression. Thus, the identification and subsequent functional evaluation of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis, identifying cervical cancer molecular markers, and developing specific targeting strategies against tumor cells. Therefore, in this paper, we discuss the main diagnostic methods, management strategies, and followup of HPV-associated cervical lesions and review clinical trials applying gene therapy strategies against the development of cervical cancer.

Molecular detection of human papillomavirus in Brazilian women with cervical intraepithelial neoplasia in a northeast Brazilian city

“…HPV genotyping has important applications in the screening, evaluation, and monitoring of low-grade cervical intraepithelial neoplasia (Peralta-Zaragoza et al, 2013).…”

MicroRNA-101 Inhibits Cell Proliferation, Invasion, and Promotes Apoptosis by Regulating Cyclooxygenase-2 in Hela Cervical Carcinoma Cells

“…In 2008, there are 529,800 new cases of cervical cancer to estimated, 25.51 million deaths, 85% of which were new cases in the developing countries (Shen et al, 2013). The most important etiologic agent in the pathogenesisis human papilloma virus (HPV), However, not all women infected with high-risk HPV develop cervical carcinoma, there are also related to some changes in genetic abnormalities, such as the aberrantion of miRNAs (Forman et al, 2012;Peralta-Zaragoza et al, 2013).…”

Causative relations between human papilloma virus infection and cervical intraepithelial neoplasia

“…[1] Following the histologic identification of CIN, treatment is recommended for high-grade pre-invasive lesions. [1] Human papilloma virus (HPV) is recognized as a main etiological agent causing CIN.…”

“…[1] Following the histologic identification of CIN, treatment is recommended for high-grade pre-invasive lesions. [1] Human papilloma virus (HPV) is recognized as a main etiological agent causing CIN. [2] The major factor in cervical carcinogenesis is HPV infection, with HPV persistence for a certain period of time, progression to precancer and invasion.…”