HPV DNA and Pap smear test results in cases with and without cervical pathology

Abstract

Objective:The aim of the study was to determine the HPV prevalance and its relation to Pap smear, colposcopy and colposcopy directed biopsy in our region of Eskisehir, Turkey. Material and Methods:A total of 615 women who applied to the outpatient clinic between December 2009 and December 2010 constituted our study population. All patients underwent pelvic examination and Pap smear sampling. Patients who had pathological cervical appearance or Pap smear results of ASCUS, AGUS, LSIL or HSIL were referred to colposcopy. Cervical samples for HPV DNA were taken from the patients before Pap smear sampling during the routine examination or before the colposcopic evaluation.Results: Twenty six of 615 patients (4%) were HPV positive. Of these 26 patients, 12 were positive for HPV type 16, 3 for type 18, 3 for type 51, 2 for type 6, 1 for type 52, 1 for type 33, 1 for type 16 and type 31, 1 for type 6 and 52, 1 for type 56 and 90, 1 for type 39 and 66. In 4 patients with cervical cancer, and in 3 of 4 CIN III cases both HPV DNA and Pap smear were positive. In the Pap smear examination of 615 patients, cytology revealed 35 ASCUS (5.6%) 4 AGUS (0.6%), 2 CIN I (0.3%) results who were negative for HPV DNA. These patients with abnormal cytology (n=41) underwent colposcopy directed biopsy, there were 3 CIN I and 1 CIN III and all the other cervical biopsy results of these patients were benign (inflammation, chronic cervicitis). Conclusion:HPV positivity in our hospital setting is low which is compatible with other studies in Turkey. In positive HPV cases there is a good correlation between HPV type and positive cervical biopsy results. (J Turkish-German Gynecol Assoc 2012; 13: 8-14) Key words: HPV DNA, Pap smear, colposcopy directed biopsy Received: 14 August, 2011 Accepted: 11 September, 2011 Amaç: Çalışmanın amacı Türkiye'nin Eskişehir bölgesinde HPV prevalansı ve bunun Pap smear, kolposkopi ve kolposkopik biopsi ile iliş-kisini belirlemektir.

Population-Based Cervical Screening Outcomes in Turkey over a Period of Approximately Nine and a Half Years with Emphasis on Results for Women Aged 30-34

“…But, the rates of the present study were much lower than the ones reported for Western populations, in general (de Sanjose et al, 2003;Duggan et al, 2006;Kroupis et al, 2007;Kulig et al, 2010;Marques et al, 2011). However, our results were very similar to those reported from other Islamic countries like Saudi Arabia, Egypt, and Iran (Jamal et al, 2003;elAll et al, 2007;Nokiani et al, 2008) that may be ascribed to low prevalence of HPV (Tuncer et al, 2006;Ozalp et al, 2012), religion, or the conservative cultures, akin to Turkish population. Besides, the mentioned rates detected by cervical screening may also vary with the nature of populations screened.…”

Impact of HPV infection on oral squamous cell carcinoma

“…Furthermore, this study demonstrated that HPV infection only occurs in a relatively small number of OSCC cases. In the literature, the rate of HPV positivity in HNSCC is provided with a wide range and often substantially differs between from one study to another [32, 33]. Further examination of published data shows that the wide range of HPV+ status in SCC is the result of poor differentiation between OSCC and OPSCC [34, 35].…”

Relationship between Human Papillomavirus Status and Cervical Cytological Abnormalities in a Low Risk Turkish Population

“…In a meta-analysis including 576.281 patients from 120 studies HPV prevalence was found 32.1% worldwide [11]. In Turkey, the prevalence of HPV was found between 2.1 to 38.9% in different studies [12][13][14][15][16][17]. The HPV infection rate in patients with abnormal cytology is higher.…”

“…Table 4 summarizes the recent studies with available full-text from Turkey investigating the relationship between HPV status and abnormal cytological results. The previous studies from Turkey reported the rate of HPV infection among patients with abnormal cervical cytology between 12% and 80% [13][14][15][16][17][18][19][20][21][22][23][24][25]. This wide range probably originated from the detection method used.…”