HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988–2007)

Abstract

These findings support the assumption that a correct distinction of HNSCC by site, together with the use of more sensitive HPV DNA detection methods, should be considered as essential prerogatives in designing future investigations into viral prevalence in head and neck tumors.

Risk Stratification of Early Stage Oral Tongue Cancers Based on HPV Status and p16 Immunoexpression

“…A high prevalence of HPV in oral cancers from India has been reported previously, suggesting that viral agents could cause additional mutations in the carcinogenic process, together with dietary habits and probably, in the presence of a given genetic predisposition (Balaram et al, 1995). A meta-analysis by Termine et al showed that overall prevalence of HPV DNA in oral SCC was 38.1% (Termine et al, 2008). With regards to the detection method, PCRbased studies reported a higher prevalence rate than ISH-based rates (39.9% versus 32.9%).…”

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

“…Our Li-Li Gan et al previous study with 44 patients showed that the incidence of HPV infection in OSCC in Wuhan was 40.4% (Zhao et al, 2009). This discrepancy might attribute to the different anatomic locations of tumors and techniques used to detect HPV-DNA (Termine et al, 2008). But the epidemiology studies including our previous study in Chinese population were almost limited by small samples, which cannot precisely reflect the real situation of HPV infection in China.…”

“…The discrepancy of different HPV prevalence found in OSCC in different studies might attribute to different anatomic locations of tumors, different sample origins (such as formalin-fixed, fresh biopsies, or oral exfoliated cells), different techniques used to detect HPV existence (such as PCR, P16 immunohistochemistry and in situ hybridization) (Termine et al, 2008) and different population involved in epidemiology studies. For example, the epidemiology in USA is about 38% infection in OSCC, whereas the meta-analysis of Chinese population indicated the prevalence in China is 47.47% (Termine et al, 2008;Zhu et al, 2012).…”

“…For example, the epidemiology in USA is about 38% infection in OSCC, whereas the meta-analysis of Chinese population indicated the prevalence in China is 47.47% (Termine et al, 2008;Zhu et al, 2012). Furthermore, the case numbers enrolled in epidemiology study in China were much smaller than those in other countries.…”

“…It was reported that the incidence of OSCC that potentially HPV-related increased in the USA from 1973-2004 partly due to the changes in sexual behavior, especially in young adults (Chaturvedi et al, 2008;Jemal et al, 2011Jemal et al, ). A meta-analysis (1988Jemal et al, -2007 showed that the prevalence of HPV DNA in OSCC was 38.1% (Termine et al, 2008). HPV-16 genomic DNA can be detected in 16.5% to 19% of oral cancers in the USA (Schwartz et al, 1998;Smith et al, 2004).…”