HPV infections and lung cancer

Syrjänen, Karí

doi:10.1136/jcp.55.12.885

Cited by 124 publications

(122 citation statements)

References 79 publications

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“…The most frequently detected genotype in the present study was HPV-16, which accounted for 55% of HPV-positive cases, as was also the case in our previous study conducted in other Latin-American countries, including Mexico, Colombia, and Chile (Castillo et al, 2006). Our findings are also in accordance with those shown in a review published by Syrjänen (2002), where HPV was positive in 25% of SQCs, 19% of SCCs, and 8% of ACs. Physical status of HPV was determined by HPV E2/E6 ratio in the present study, and most of the HPV-16-positive SQCs were considered to have HPV-16 in the integrated form, and about half of the integrated HPV-16 was accompanied by episomal HPV-16.…”

Section: Discussionsupporting

confidence: 93%

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Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

et al. 2007

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The human papillomavirus (HPV) was detected in 20 (29%) out of 69 lung carcinomas (LCs) in Chile, by PCR and Southern blot, and was more frequently detected in squamous cell carcinoma (SQC) than in adenocarcinomas (46 vs 9%, P ¼ 0.001). HPV-16, positive in 11 cases, was the most frequently detected HPV genotype determined by DNA sequencing. HPV-16 E2/E6 ratio, estimated from real-time PCR analysis, was much lower than the unity, suggesting that at least a partial HPV-16 genome was integrated in all but one HPV-16-positive SQCs. The remaining one case was suspected to have only episomal HPV-16. Although the viral load was low in most of the LCs, a case showed the HPV-16 copy number as high as 8479 per nanogram DNA, which was even a few times higher than the minimum viral load of seven cervical carcinomas (observed viral load: 3356 -609 392 per nanogram DNA). The expression of the HPV-16/18 E6 protein was found in only two HPV-16-positive SQCs (13%) but not in the case with the highest viral load. Although the viral load was in general very low and HPV E6 expression is none or weak, further studies seem warranted to examine aetiological involvement of high-risk HPV in lung carcinogenesis.

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Section: Discussionsupporting

confidence: 93%

“…Human papillomavirus is also reported to be detected in lung carcinomas (LCs). A recent review (Syrjänen, 2002) of all the studies reported until 2001 showed that HPV was detected in 536 out of 2468 (22%) bronchial carcinomas.…”

mentioning

confidence: 99%

Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

et al. 2007

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“…In other studies, the prevalence of HPV in lung carcinomas ranges from 0 to 100%. 7 The high heterogeneity of these results can be largely explained by the mode of sampling: in fresh frozen tissue samples the DNA is less degraded than in paraffin-embedded tissues where it can be fragmented and/or modified and thus is very difficult to work with. Several techniques with different sensibilities and specificities have been used to detect HPV.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies have then used PCR, which is much more sensitive, but with difficulties to obtain large amplimers, notably when paraffin-embedded tissues are used and still again with high discrepancies. 7 That is why in our study fresh frozen tissues were chosen. Moreover, the PCR technique used in our present work has been validated in numerous studies in cervical pathology.…”

Section: Discussionmentioning

confidence: 99%

“…6 Previously, numerous studies had been undertaken principally on squamous cell carcinoma of the lung, but according to the literature the link between HPV and carcinogenesis of lung cancers remains unclear. 7 In a previous study in our laboratory, the Hybrid Capture II technique was used for the detection of HPV on 185 lung tumours. 8 Although it is highly sensitive, this technique can be defective 9,10 missing some HPV-HR infections.…”

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confidence: 99%

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Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases

et al. 2005

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High-risk human papillomaviruses (HPV) are largely implicated in the carcinogenesis of cervical carcinomas. Their role in bronchopulmonary carcinomas is still unclear. In the present study, we have explored 218 fresh frozen lung tumours for the presence of HPV with the Roche line blot assay and for the expression of mRNAs encoding E6 oncoprotein in HPV positive tumours. Only four samples were positive for HPV detection, one poorly differentiated squamous cell carcinoma and three large cell carcinomas. E6 mRNA was undetectable in these four samples. Our data confirm the low prevalence of HPV in lung carcinomas in Western European countries and do not plead in favour of a carcinogenic role for HPV in these carcinomas.

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Association of p73 G4C14‐to‐A4T14 polymorphism with human papillomavirus type 16 status in squamous cell carcinoma of the head and neck in non‐Hispanic whites

Zhao

Etzel

et al. 2009

Cancer

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BACKGROUND:The tumor protein p73 interacts with the human papillomavirus type 16 (HPV‐16) oncoproteins E6 and E7, and p73 variation may modify the interaction between p73 protein and HPV‐16 oncogenic proteins and contribute to cellular malignant transformation.METHODS:In this case‐case comparison study, the authors analyzed HPV‐16 status in tumor specimens and genotyped the p73 G4C14‐to‐A4T14 polymorphism using genomic DNA from blood of 202 non‐Hispanic white patients with squamous cell carcinoma of the head and neck (SCCHN). Odds ratio (OR) and 95% confidence intervals (95% CIs) were calculated in univariate and multivariable logistic regression models to examine the association between the p73 polymorphism and HPV‐16 status in SCCHN.RESULTS:Compared with the p73 GC/GC genotype, the AT/AT and combined GC/AT + AT/AT variant genotypes were associated significantly with HPV‐16‐positive tumor status among patients with SCCHN (adjusted OR, 5.32; 95% CI, 1.32‐21.4; adjusted OR, 1.91; 95% CI, 1.03‐3.53, respectively). There was a significant dose‐effect relation between the AT allele and HPV‐16‐positive tumor status in patients with SCCHN (trend test: P = .014). Moreover, the stratified analyses indicated that the association between HPV‐16‐positive tumor status and the combined p73 GC/AT + AT/AT genotypes was more pronounced among several subgroups of patients who were older, men, ever drinkers, and those with oropharyngeal cancer.CONCLUSIONS:The p73 polymorphism was associated with HPV‐16 status in SCCHN and may serve as a marker of positive HPV‐16 tumor status in patients with SCCHN, particularly those with oropharyngeal cancer. Cancer 2009. © 2009 American Cancer Society.

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HPV infections and lung cancer

Cited by 124 publications

References 79 publications

Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile

Prevalence of human papillomaviruses in lung carcinomas: a study of 218 cases

Association of p73 G4C14‐to‐A4T14 polymorphism with human papillomavirus type 16 status in squamous cell carcinoma of the head and neck in non‐Hispanic whites

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