HPV infections in benign and malignant sinonasal lesions

Syrjänen, Karí

doi:10.1136/jcp.56.3.174

Cited by 147 publications

(131 citation statements)

References 95 publications

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“…Several studies have been performed and the results are mixed with the range of HPV DNA present varying from 0 to 100% (17,18,38) in the IP specimens. Recent studies demonstrate that HPV could be associated with 33% of IP (39). In over 90 types of HPV that are known to date, only a few are linked with malignant transformation.…”

Section: Histopathologymentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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Section: Histopathologymentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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“…The clinical and morphological features of each are quite distinct, and although some overlap exists, they should not be lumped together for diagnostic purposes as ''Schneiderian papilloma'' without further qualification. The etiology of FSP and ISP has long been thought to be human papillomavirus infection, particularly with low risk HPV serotypes 6 and 11 [2,[4][5][6]. HPV DNA has been identified, using various techniques and combining the results of several studies, in approximately one third of papillomas [5].…”

Section: Schneiderian Papillomas Backgroundmentioning

confidence: 99%

Low-Grade Epithelial Proliferations of the Sinonasal Tract

Bullock

2016

Head and Neck Pathol

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Low-grade epithelial proliferations of the sinonasal tract include Schneiderian papillomas, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma and low-grade non-intestinal adenocarcinoma. There is considerable overlap in their clinical presentation, endoscopic appearance, and imaging features. Although well-described diagnostic criteria exist, a definitive diagnosis may be difficult to reach on a small biopsy. Schneiderian papillomas are divided into fungiform, inverted, and oncocytic types, each with characteristic clinical and morphological features. The latter two may progress to malignancy. The majority are still considered to be HPVrelated. Two lesions are designated as hamartomas, but their pathogenesis remains uncertain, with inflammatory and neoplastic origins proposed. Respiratory epithelial adenomatoid hamartoma is increasingly being recognized for its association with chronic rhinosinusitis and olfactory cleft site of origin. Seromucinous hamartoma has gained attention in recent years and overlaps with both respiratory epithelial adenomatoid hamartoma and low-grade non-intestinal adenocarcinoma. Controversy surrounds their distinction, particularly from low-grade adenocarcinoma. The latter generally is cured by complete excision, with a 26 % risk of recurrence but rare metastases and deaths from disease.

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“…With this highly sensitive and quantitative method tissuespecific expression of hundreds of genes can be stud- Human papilloma virus (HPV)-induced pre-neoplastic lesions can precede cancerous transformation of skin and mucosal surface epithelium. 1,2 Innate and/or adaptive immunity seem to provide some control of HPV infection and/or replication, since HPV-induced oral warts are more common in HIV-infected patients and in immunocompromised renal transplant recipients compared to fully immunocompetent persons. 3,4 Interestingly, the incidences of oral warts seem to increase in HIV ϩ patients on highly active anti-retroviral therapy (HAART), 5,6 a treatment that leads to the reconstitution of the peripheral immune system.…”

mentioning

confidence: 99%

Highly Tissue Substructure-Specific Effects of Human Papilloma Virus in Mucosa of HIV-Infected Patients Revealed by Laser-Dissection Microscopy-Assisted Gene Expression Profiling

Baumgarth¹,

Szubin²,

Dolganov³

et al. 2004

The American Journal of Pathology

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Human papilloma virus (HPV) causes focal infections of epithelial layers in skin and mucosa. HIV-infected patients on highly active antiretroviral therapy (HAART) appear to be at increased risk of developing HPV-induced oral warts. To identify the mechanisms that allow long-term infection of oral epithelial cells in these patients, we used a combination of laserdissection microscopy (LDM) and highly sensitive and quantitative, non-biased, two-step multiplex realtime RT-PCR to study pathogen-induced alterations of specific tissue subcompartments. Expression of 166 genes was compared in three distinct epithelial and subepithelial compartments isolated from biopsies of normal mucosa from HIV-infected and non-infected patients and of HPV32-induced oral warts from HIVinfected patients. In contrast to the underlying HIV infection and/or HAART, which did not significantly elaborate tissue substructure-specific effects, changes in oral warts were strongly tissue substructure-specific. HPV 32 seems to establish infection by selectively enhancing epithelial cell growth and differentiation in the stratum spinosum and to evade the immune system by actively suppressing inflammatory responses in adjacent underlying tissues. With this highly sensitive and quantitative method tissuespecific expression of hundreds of genes can be stud- Human papilloma virus (HPV)-induced pre-neoplastic lesions can precede cancerous transformation of skin and mucosal surface epithelium.

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HPV infections in benign and malignant sinonasal lesions

Cited by 147 publications

References 95 publications

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Low-Grade Epithelial Proliferations of the Sinonasal Tract

Highly Tissue Substructure-Specific Effects of Human Papilloma Virus in Mucosa of HIV-Infected Patients Revealed by Laser-Dissection Microscopy-Assisted Gene Expression Profiling

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