HPV‐positive oral papillomas in an adolescent—A diagnostic dilemma

Benyo, Sarah; Keane, Allison; Warrick, Joshua; Choi, Karen Y.

doi:10.1002/ccr3.4546

Cited by 5 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The virus has a hexahedral symmetry capsid (consisting of pentameric capsomeres) and has two structural proteins, L1 and L2 [ 67 , 68 ]. Oral HPV is often sexually transmitted, but nonsexual modes of transmission should be considered, including autoinoculation from skin lesion HPV in adolescent and pediatric patients [ 69 , 70 ]. The HPV infection is commonly is commomly associated to benign lesions (vulgar warts, warts, focal epithelial hyperplasia, squamous cell papilloma, Bowen's papillomatosis), or to cancerous lesions such as squamous cell carcinoma (SCC) [ 64 ].…”

Section: Risk Factors For Oral Cancer In Pediatric Dentistrymentioning

confidence: 99%

“…Since HPV does not have a protein or ribosomal synthesis, for its proliferation, it employs the genetic mechanism of the host cell [ 69 , 70 ]. The virus uses, to direct the metabolic functions of the host cell in its favor, the production of viral messenger RNA, which is produced by transcription of viral genetic material.…”

Section: Risk Factors For Oral Cancer In Pediatric Dentistrymentioning

confidence: 99%

See 1 more Smart Citation

Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Muzio

Ballini

Cantore

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Oral carcinoma represents one of the most common malignancies worldwide. Oral squamous cell carcinomas (OSCCs) account over 90% of all oral malignant tumors and are characterized by high mortality in the advanced stages. Early diagnosis is often a challenge for its ambiguous appearance in early stages. Mucosal infection by the human papillomavirus (HPV) is responsible for a growing number of malignancies, particularly cervical cancer and oropharyngeal carcinomas. In addition, Candida albicans (C. albicans), which is the principal fungi involved in the oral cancer development, may induce carcinogenesis through several mechanisms, mainly promoting inflammation. Medical knowledge and research on adolescent/pediatric patients’ management and prevention are in continuous evolution. Besides, microbiota can play an important role in maintaining oral health and therefore all human health. The aim of this review is to evaluate epidemiological and pathophysiological characteristics of the several biochemical pathways involved during HPV and C. albicans infections in pediatric dentistry.

show abstract

Section: Risk Factors For Oral Cancer In Pediatric Dentistrymentioning

confidence: 99%

Section: Risk Factors For Oral Cancer In Pediatric Dentistrymentioning

confidence: 99%

Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Muzio

Ballini

Cantore

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Although malignant transformation of LP occurs in less than 3% of cases [ 4 , 5 ], multiple surgeries, including tracheostomy, may be required in order to maintain the airway [ 3 ]. Human papillomavirus oral papilloma is often sexually transmitted, but non-sexual modes of transmission should be considered [ 6 ], including hand-to-mouth transmission and vertical transmission during pregnancy or childbirth. According to a recent report [ 7 ], juvenile-onset LP is caused by only one type of HPV in the vast majority of cases (95.6%), consisting primarily of HPV-6 (79.6%) and to a lesser degree HPV-11 (15.4%).…”

Section: Introductionmentioning

confidence: 99%

Development of Antibodies against HPV-6 and HPV-11 for the Study of Laryngeal Papilloma

Ikegami

Kise

Kinjyo

et al. 2021

Viruses

View full text Add to dashboard Cite

Laryngeal papilloma (LP), which is associated with infection by human papillomavirus (HPV)-6 or -11, displays aggressive growth. The precise molecular mechanism underlying the tumorigenesis of LP has yet to be uncovered. Building on our earlier research into HPV-6, in this study, the viral gene expression of HPV-11 was investigated by quantitative PCR and DNA/RNA in situ hybridization. Additionally, newly developed antibodies against the E4 protein of HPV-6 and HPV-11 were evaluated by immunohistochemistry. The average viral load of HPV-11 in LP was 1.95 ± 0.66 × 105 copies/ng DNA, and 88% of HPV mRNA expression was found to be E4, E5a, and E5b mRNAs. According to RNA in situ hybridization, E4 and E5b mRNAs were expressed from the middle to upper part of the epithelium. E4 immunohistochemistry revealed a wide positive reaction in the upper cell layer in line with E4 mRNA expression. Other head and neck lesions with HPV-11 infection also showed a positive reaction in E4 immunohistochemistry. The distribution pattern of HPV DNA, viral mRNA, and E4 protein in LP with HPV-11 infection was quite similar to that of HPV-6. Therefore, it might be possible to apply these E4-specific antibodies in other functional studies as well as clinical applications, including targeted molecular therapies in patients with HPV-6 and HPV-11 infection.

show abstract

Changing Trends in Benign Human Papillomavirus (HPV) Related Epithelial Neoplasms of the Oral Cavity: 1995–2015

Alramadhan

Fitzpatrick

Bhattacharyya

et al. 2022

Head and Neck Pathol

View full text Add to dashboard Cite

HPV‐positive oral papillomas in an adolescent—A diagnostic dilemma

Abstract: Human papillomavirus oral papilloma is often sexually transmitted, but non‐sexual modes of transmission should be considered, including autoinoculation from skin lesions. A patient‐centered multimodality approach should be utilized in the pediatric population.

Cited by 5 publications

References 8 publications

Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Overview of Candida albicans and Human Papillomavirus (HPV) Infection Agents and their Biomolecular Mechanisms in Promoting Oral Cancer in Pediatric Patients

Development of Antibodies against HPV-6 and HPV-11 for the Study of Laryngeal Papilloma

Changing Trends in Benign Human Papillomavirus (HPV) Related Epithelial Neoplasms of the Oral Cavity: 1995–2015

Contact Info

Product

Resources

About