HPV Vaccination and Complex Regional Pain Syndrome: Lack of Evidence

Weinbaum, Cindy M.; Cano, Maria

doi:10.1016/j.ebiom.2015.08.030

Cited by 9 publications

(6 citation statements)

References 8 publications

(10 reference statements)

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“…In a review of VAERS reports, between 2006 and July 23, 2015, there were 21 reports of CRPS related reports following 4vHPV (MedDRA search terms: “complex regional pain syndrome” and “mononeuropathy multiplex”). 45 With over 80 million doses of 4vHPV distributed in the United States through September 2015, the findings from VAERS indicate that CRPS is rare following HPV vaccination.…”

Section: Specific Conditionsmentioning

confidence: 99%

Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States

Gee

Weinbaum

Sukumaran

et al. 2016

Human Vaccines & Immunotherapeutics

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Quadrivalent human papillomavirus (4vHPV) vaccine was licensed for use in the United States in 2006 and through 2015 was the predominate HPV vaccine used. With the exception of syncope, a known preventable adverse event after any injected vaccination, both pre-licensure and post-licensure 4vHPV safety data have been reassuring with no confirmed safety signals identified. Nine-valent HPV vaccine (9vHPV) was licensed in 2014. This review includes post-licensure 4vHPV safety findings published to date that have informed the US vaccination program; these data will inform US safety monitoring and evaluation for 9vHPV.

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Section: Specific Conditionsmentioning

confidence: 99%

Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States

Gee

Weinbaum

Sukumaran

et al. 2016

Human Vaccines & Immunotherapeutics

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“…Vaccine side effects are generally localized injection neuritis from the direct trauma, mass effect from the injected material, or, more rarely, caused by a direct toxic effect of the injected material, though CRPS has been reported [13]. Penetration trauma is more than likely the impetus for CRPS onset, as there is insufficient data claiming that the viral antigens of the injectant play a role, which was heavily analyzed for human papillomavirus [2,14].…”

Section: Discussionmentioning

confidence: 99%

“…Sciatic neuropathy is the most commonly reported, but most injections, including vaccinations, carry some degree of risk [1]. Development of complex regional pain syndrome (CRPS) after an injection, however, is uncommon, and its variable manifestations may delay the diagnosis and subsequent treatment of the syndrome for significant periods of time [1][2][3]. CRPS symptoms have been recognized by multiple names over the course of its study.…”

Section: Introductionmentioning

confidence: 99%

Intramuscular Injection and Complex Regional Pain Syndrome Development After “Harmless” Procedures

Babineau

Alweis

2020

Cureus

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Complex regional pain syndrome (CRPS) is a puzzling pain condition, typically occurring after trauma. Incidents as innocent as IV injection and vaccine administration may serve as the impetus for an as yet poorly understood cascade of neuro-inflammation and somatosensory changes. A condition with variable degrees of psychological involvement, disability, and purely clinical diagnostic criteria, the diagnosis is often significantly delayed before effective treatment is begun, decreasing the likelihood of success. A 58-year-old female initially presented with painless peripheral edema of the left arm without erythema or loss of function, with later bilateral development of multiple domains of symptoms consistent with CRPS. Plausible initiation events in this instance were an IV insertion in the left cubital fossa and vaccination into the right deltoid. Delay in diagnosis is common but utilization of the Budapest Criteria for diagnosis and prompt treatment improves outcomes.

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“…Two large US data mining studies did not identify any signals for CRPS or POTS., 68 69 Monitoring from the US Vaccine Adverse Event Reporting System found few reports of CRPS or POTS and no patterns to suggest a causal association with either Cervarix, Gardasil, or Gardasil-9. 70 71 72 An extensive review of GlaxoSmithKline’s safety database for CRPS following Cervarix also did not find an increase in the incidence of CRPS following vaccination. 73 In 2015, the EMA conducted a detailed expert review of CRPS and POTS following HPV vaccines from a variety of data sources and concluded that the available evidence does not support that CRPS or POTS are caused by HPV vaccine.…”

Section: Hpv Vaccine and Pots And Crpsmentioning

confidence: 99%

Novel vaccine safety issues and areas that would benefit from further research

et al. 2021

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Vaccine licensure requires a very high safety standard and vaccines routinely used are very safe. Vaccine safety monitoring prelicensure and postlicensure enables continual assessment to ensure the benefits outweigh the risks and, when safety problems arise, they are quickly identified, characterised and further problems prevented when possible. We review five vaccine safety case studies: (1) dengue vaccine and enhanced dengue disease, (2) pandemic influenza vaccine and narcolepsy, (3) rotavirus vaccine and intussusception, (4) human papillomavirus vaccine and postural orthostatic tachycardia syndrome and complex regional pain syndrome, and (5) RTS,S/adjuvant system 01 malaria vaccine and meningitis, cerebral malaria, female mortality and rebound severe malaria. These case studies were selected because they are recent and varied in the vaccine safety challenges they elucidate. Bringing these case studies together, we develop lessons learned that can be useful for addressing some of the potential safety issues that will inevitably arise with new vaccines.

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HPV Vaccination and Complex Regional Pain Syndrome: Lack of Evidence

Cited by 9 publications

References 8 publications

Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States

Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States

Intramuscular Injection and Complex Regional Pain Syndrome Development After “Harmless” Procedures

Novel vaccine safety issues and areas that would benefit from further research

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