HPV vaccine acceptability in HIV-infected and HIV negative men who have sex with men (MSM) in Ireland

Abstract

Background Men who have sex with men (MSM), particularly HIV-infected MSM are disproportionately affected by HPV infection and associated disease. The HPV vaccine has potential to greatly reduce the burden of HPV-associated disease including anal cancer in MSM. The efficacy of the HPV vaccine is dependent on high levels of vaccine uptake. The aim of this study was to examine HPV vaccine acceptability and factors influencing vaccine acceptability in MSM in Ireland. Methods A self-administered survey was distributed to HIV-infected and HIV negative MSM examining HPV vaccine acceptability and factors associated with vaccine acceptability. Logistic regression was used to identify key variables and predictors of HPV vaccine acceptability. Results 302 MSM participated in the study. Acceptability of HPV vaccine was 31% (unconditional), 51% (conditional on stated efficacy and a cost of €300), 65% (conditional on stated efficacy and a cost of €100) and 78% (conditional on stated efficacy and no cost). Cost was negatively associated with HPV vaccine acceptability (p<0.01) while knowledge of HPV vaccine efficacy was significantly associated with vaccine acceptability, even in the context of associated cost (p<0.01). Conclusions Acceptability of HPV vaccine in MSM in Ireland is high based on no cost vaccine and on stated vaccine efficacy (78%). Cost is negatively associated with vaccine acceptability. Understanding levels of knowledge of HPV infection, HPV associated disease and attitudes toward HPV vaccination are important as they will contribute to HPV vaccine acceptability among MSM and will help guide effective preventive programs.

Human Papillomavirus awareness and vaccine acceptability among men who have sex with men from mainland China

“…In the present study, correlates of HPV vaccine acceptability were generally consistent with those identified in several previous studies 33,34 . The men who paid more attention to their own health and who believed that HPV vaccine could effectively protect from infection had stronger willingness to get vaccinated.…”

HPV vaccination in a context of public mistrust and uncertainty: a systematic literature review of determinants of HPV vaccine hesitancy in Europe

“…Concerns about the safety of HPV vaccination and potential long-or short-term side effects were reported by an average of 43% of hesitant study participants. [23][24][25][26][27][28][29]31,32,[34][35][36][37][38]40,42,46,49,[70][71][72][73][74][75][76][77][78][79][80][81] Fear of side effects was reported by an average of 52% of general study participants 51,[82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97] and 17% of favourable study participants. 25,37,71 Concerns about si...…”

“…In quantitative studies, cost was raised as an issue by an average of 32% of hesitant participants, 31,38,74,75,80 particularly in studies in Denmark (2009, 62%) 80 and Greece (2008-2014, 54%), 31 and was also raised as a concern for an average of 47% of general study participants in Germany, Greece, Hungary, Ireland, and Sweden. 46,47,94,97,120 The inconvenience of receiving multiple doses was reported by 56% of general participants in studies in Sweden (2007-2013), 96,110 25% of hesitant participants in studies in France (2015) 74 and the UK (2007-2008), 71 and 10% of favourable participants in a study in the UK (2007)(2008). 71 Increased workload created by administering the vaccine was raised as a barrier by general school nurses in a study in Sweden (2013, 40%), 110 while general adolescents in studies in Germany (2010, 12%) 95 and Greece (2008-2014, 1%) 31 reported being too busy to get vaccinated.…”

HPV vaccination acceptability among men who have sex with men in Urumqi, China

“…The current results suggest that the MSM population in Urumqi, China has poor knowledge of HPV, at levels relatively lower than expected compared to global data previously reported in a 2014 systematic review and other studies conducted out of China. 22,29 Although the proportion of individuals who were aware of HPV is higher among HIV-infected MSM than that of HIV-uninfected, among those who knew about HPV, HIV-uninfected had a greater correct responses rate to further survey items than HIV-infected individuals. More generally the findings of these study clearly indicate that improvement of HPV knowledge of transmission, risk factors and prevention among MSM especially high-risk MSM in Urumqi.…”