HPV-Vaccine Hesitancy in Colombia: A Mixed-Methods Study

Córdoba-Sánchez, Verónica; Lemos, Mariantonia; Tamayo-Lopera, Diego Alfredo; Gorin, Sherri Sheinfeld

doi:10.3390/vaccines10081187

Cited by 6 publications

(8 citation statements)

References 53 publications

(61 reference statements)

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“…Efforts to improve public trust and understanding of the program have since facilitated a rebound, with first-dose rates rising to 39.4% by 2021. Vaccine hesitancy has been linked to insufficient awareness, safety doubts, and connections made between HPV and sexuality [39].…”

Section: Discussionmentioning

confidence: 99%

“…HPV encompasses more than 200 viral types, where those known as high-risk (HR-HPV) are the leading cause of neoplastic lesion development. HPV-16 and − 18 are the most significant, followed by 33,35,39,45,51,52,56,58,59, and 68 [2,3]; however, type-specific frequencies vary according to the population type and geographical region analyzed [4]. Additionally, cancer development is multifactorial, influenced by various risk factors associated with sexual behavior and genetic, cultural, and social characteristics of the studied communities [5], and intrinsic characteristics of the viruses present in the infections [6].…”

Section: Introductionmentioning

confidence: 99%

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High frequency of alpha7-HPV in Colombian Caribbean coast women: cervical cancer screening analysis

Arteaga-Pautt,

Bru-Cordero,

Ricardo-Caldera

et al. 2024

BMC Infect Dis

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SUMMARY Background Cervical cancer (CC) is a significant global public health concern, particularly in developing countries such as Colombia. The main risk factor involves high-risk HPV types (HR-HPV) infection, coupled with population-specific variables. The Caribbean region in Colombia lacks research on HR-HPV-type frequencies. Therefore, this study aims to establish the prevalence of type-specific HR-HPV and its association with sociodemographic factors among women undergoing cervical cytology screening. Methods A cross-sectional study involving voluntary women who provided informed consent and completed a questionnaire capturing sociodemographic, clinical, and sexual behavior information was conducted. All participants underwent cervical cytology and molecular analysis. Generic HPV detection employed three simultaneous PCRs (GP5+/6+, MY09/11, and PU1R/2 M), and positive samples were genotyped using the Optiplex HPV Genotyping kit. The analysis encompassed the 12 types of high-risk HPV (HR-HPV-16,-18,-31,-33,-35,-39,-45,-51,-52,-56,-58, and − 59). Frequencies were reported based on geographic subregions within the Córdoba department, and disparities were made between single and multiple infections. Sociodemographic and clinical variables were subjected to ordinal logistic regression, with statistical significance at a p-value < 0.05. The statistical analyses utilized STATA 14® and R-Core Team-software. Results We included 450 women, mean age 40 (SD$$\pm$$11.44). PCR analysis revealed 43% HPV-positive (n=192). GP5+/6+ detected the most positives at 26% (n=119), followed by PU1R/2 M at 22% (n = 100) and MY09/11 at 15% (n=69). Multiple infections occurred in 87.3% (n=142), primarily 2 to 4 types (47.37%, n=90). Dominant types were HPV-18 (15.6%, n=61), HPV-16 (14.9%, n=58), HPV-31 (13.0%, n = 51), and HPV-45 (11.5%, n=45). Logistic regression identified age above 60 as a risk for concurrent multiple types (OR=6.10; 95% CI 1.18–31.63). Menopause was protective (OR=0.31; 95% CI 0.11–0.89). Conclusions Our study reveals a notable prevalence of multiple (2–4) high-risk HPV infections among adult women engaged in CC detection initiatives. Predominantly, α7 species constitute the prevalent HR-viral types, with the Medio Sinú subregion showing elevated prevalence. Menopausal status confers protection against diverse HR-HPV infections. Nevertheless, advancing age, particularly beyond 60 years, is linked to an increased susceptibility to simultaneous infections by multiple HPV-types.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High frequency of alpha7-HPV in Colombian Caribbean coast women: cervical cancer screening analysis

Arteaga-Pautt,

Bru-Cordero,

Ricardo-Caldera

et al. 2024

BMC Infect Dis

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“…Vaccine hesitancy is compromising the progress made against COVID-19 pandemic and the resultant low vaccination uptake indicates a profound social weakness in a country. Furthermore, a recent body of evidence suggested that even healthcare workers were also sceptic and hesitant to receive a jab during COVID-19 pandemic [5] .…”

Section: Vaccine Hesitancymentioning

confidence: 99%

The conundrum of new coronavirus variants and poor uptake of booster dose: building a narrative against vaccine hesitancy in Pakistan

Mubarak

Rana

Khan

et al. 2022

JUMDC

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“…For instance, the COM-B framework predicted COVID-19 vaccine acceptability in a study of healthy adults in Iran [ 34 ]. This framework has also been applied to understand and explore behavioral predictors of vaccine hesitancy in terms of HPV, MMR (measles-mumps-rubella), and influenza [ 35 – 37 ]. As such, the current study applied the COM-B model to identify barriers and facilitators of vaccination uptake to inform future evidence-based interventions aimed at increasing vaccination uptake among PWUD.…”

Section: Introductionmentioning

confidence: 99%

Identifying barriers and facilitators to COVID-19 vaccination uptake among People Who Use Drugs in Canada: a National Qualitative Study

et al. 2023

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Background People Who Use Drugs (PWUD) have lower vaccination uptake than the general population, and disproportionately experience the burden of harms from vaccine-preventable diseases. We conducted a national qualitative study to: (1) identify the barriers and facilitators to receiving COVID-19 vaccinations among PWUD; and (2) identify interventions to support PWUD in their decision-making. Methods Between March and October 2022, semi-structured interviews with PWUD across Canada were conducted. Fully vaccinated (2 or more doses) and partially or unvaccinated (1 dose or less) participants were recruited from a convenience sample to participate in telephone interviews to discuss facilitators, barriers, and concerns about receiving COVID-19 vaccines and subsequent boosters, and ways to address concerns. A total of 78 PWUD participated in the study, with 50 participants being fully vaccinated and 28 participants partially or unvaccinated. Using thematic analysis, interviews were coded based on the capability, opportunity, and motivation-behavior (COM-B) framework. Results Many partially or unvaccinated participants reported lacking knowledge about the COVID-19 vaccine, particularly in terms of its usefulness and benefits. Some participants reported lacking knowledge around potential long-term side effects of the vaccine, and the differences of the various vaccine brands. Distrust toward government and healthcare agencies, the unprecedented rapidity of vaccine development and skepticism of vaccine effectiveness were also noted as barriers. Facilitators for vaccination included a desire to protect oneself or others and compliance with government mandates which required individuals to get vaccinated in order to access services, attend work or travel. To improve vaccination uptake, the most trusted and appropriate avenues for vaccination information sharing were identified by participants to be people with lived and living experience with drug use (PWLLE), harm reduction workers, or healthcare providers working within settings commonly visited by PWUD. Conclusion PWLLE should be supported to design tailored information to reduce barriers and address mistrust. Resources addressing knowledge gaps should be disseminated in areas and through organizations where PWUD frequently access, such as harm reduction services and social media platforms.

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HPV-Vaccine Hesitancy in Colombia: A Mixed-Methods Study

Cited by 6 publications

References 53 publications

High frequency of alpha7-HPV in Colombian Caribbean coast women: cervical cancer screening analysis

High frequency of alpha7-HPV in Colombian Caribbean coast women: cervical cancer screening analysis

The conundrum of new coronavirus variants and poor uptake of booster dose: building a narrative against vaccine hesitancy in Pakistan

Identifying barriers and facilitators to COVID-19 vaccination uptake among People Who Use Drugs in Canada: a National Qualitative Study

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