2014
DOI: 10.1002/ijc.29373
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HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial‐mesenchymal transition

Abstract: The E5 oncoprotein of the human papillomavirus type 16 (HPV16 E5) deregulates epithelial homeostasis through the modulation of receptor tyrosine kinases and their signaling. Accordingly, the fibroblast growth factor receptor 2b (FGFR2b/KGFR), epithelial splicing transcript variant of the FGFR2, is down-modulated by the viral protein expression, leading to impairment of keratinocyte differentiation. Here, we report that, in cell models of transfected human keratinocytes as well as in cervical epithelial cells c… Show more

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Cited by 50 publications
(55 citation statements)
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“…As presented in the subsection Splicing Factor Missregulation: Summarizing Some Findings and tables 1 and 2, changes in the expression levels of splicing factors after exposure to EMT-driven stimuli have been observed [4,22,23,28,30]. The transcription factors of the Snail, Twist and ZEB families are the hitherto known effectors of EMT, acting as repressors of epithelial markers.…”
Section: Outside Stimuli Cause Cell Reprogramming and Changes In The mentioning
confidence: 99%
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“…As presented in the subsection Splicing Factor Missregulation: Summarizing Some Findings and tables 1 and 2, changes in the expression levels of splicing factors after exposure to EMT-driven stimuli have been observed [4,22,23,28,30]. The transcription factors of the Snail, Twist and ZEB families are the hitherto known effectors of EMT, acting as repressors of epithelial markers.…”
Section: Outside Stimuli Cause Cell Reprogramming and Changes In The mentioning
confidence: 99%
“…TGF-β, the gold standard, has been used to efficiently induce EMT [4,22,23,24]. However, several stimuli can trigger EMT [25,26,27,28,29]. It is important to highlight that several of these stimuli, mainly cytokines and growth factors, activate signaling pathways and transcription factors as effectors, which can further modulate the activity and expression of splicing factors [30].…”
Section: Outside Stimuli Cause Cell Reprogramming and Changes In The mentioning
confidence: 99%
“…Furthermore, development of glucose intolerance in obesity leads to additional induction of this gene expression (+86 %) as compared to obese men with normal glucose intolerance. Additionally, we studied how expression of transcription factors HIF1A and EPAS1/ HIF2A, which mediate numerous hypoxiainduced processes including proliferation in cell-specific manner, is affected by obesity and its complications, because there is data [24,25] that transcription factor E2F8 can create complexes with other members of E2F family of transcription factors and in cooperation with HIF1 coordinates the regulation of the expression of target genes, thereby regulating cell cycle and angiogenesis, including transcriptional …”
Section: Controlmentioning
confidence: 99%
“…An important role in the control of angiogenesis also play cysteine-rich angiogenic inducer 61 (CYR61), brain-specific angiogenesis inhibitor 2 (BAI2), platelet derived growth factor C (PDGFC), fibroblast growth factors and their receptors, and some transcription factors like hypoxia inducible factor 1a (HIF1A), endothelial PAS domain protein 1 (EPAS1/HIF2A), and E2F8 (transcription factor of E2F family) [18][19][20][21][22][23][24][25]. Thus, CYR61 and PDGFC play an important role in proliferation and angiogenesis [18,20].…”
Section: Introductionmentioning
confidence: 99%
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