HR-pQCT based FE analysis of the most distal radius section provides an improved prediction of Colles' fracture load in vitro

A survey of micro-finite element analysis for clinical assessment of bone strength: The first decade

“…However, parameters used in one study are not the same as those in other studies. For example, the Young's modulus used in the studies of Mueller et al (2011a) and Macneil and Boyd (2008a) (6.83 GPa), is much less than that used in the work of Pistoia et al (2004) (10 GPa) and Varga et al (2010) (15 GPa). Using the lower value of 6.83 GPa in combination with the Pistoia criterion provides good estimates of bone strength as measured in experiments using intact distal arms, but does not well predict the strength as measured in experiments that use extracted radii with embedded ends.…”

“…Other validation studies therefore have proposed a better controlled experimental setup. In their validation study, Varga et al (2010) extracted the distal radius and embedded it on both ends before testing, thus providing well controlled boundary conditions. Using a tissue Young's modulus of 15 GPa and the standard 'Pistoia criterion', they found a coefficient of determination between measured and predicted failure loads of 0.92, and a slope of 1.03, indicating that accurate predictions of bone strength can be obtained when well controlled experimental tests are used.…”

“…In many studies, however, no strength values are reported, but stiffness is reported. Since for the clinically scanned section stiffness and strength are highly correlated (Macneil and Boyd, 2008a;Varga et al, 2010), stiffness predictions will be included as well.…”

High-Resolution Imaging Techniques for Bone Quality Assessment

“…It is important to note that this method does not account for differences in bone length and therefore positioning may be a confounding source of variability in cross-sectional studies [152]. In the radius, the default axial scan location has been found to partially overlap with the most common site for fracture and region where the cortical and trabecular structure are most strongly associated with whole bone strength [153,154].…”

Osteocytes Characterization Using Synchrotron Radiation CT and Finite Element Analysis

“…A compression test was simulated by encastring the nodes (all six degrees of freedom = 0) at the basis of the mesh and a distributed load on the top of the model. For comparison with other studies, the material properties were taken from literature (Boutroy et al 2008;Rincon-Kohli et al 2009;Varga et al 2011;Vilayphiou et al 2011). The materials were modeled to be isotropic and homogeneous and to possess a linear elastic behavior.…”