HRCT features distinguishing pre-invasive from invasive pulmonary adenocarcinomas appearing as ground-glass nodules

Zhang, Yu; Shen, Yan; Qiang, Jin Wei; Ye, Jian Ding; Zhang, Jie; Zhao, Rui

doi:10.1007/s00330-015-4131-3

Cited by 72 publications

(54 citation statements)

References 26 publications

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“…Furthermore, there was no statistic difference of position, shape, margin, bronchus sign, pleural indentation, vascular convergence, CT GGO , and ΔCT GGO-LP between IAC and AIS-MIA groups. These findings are consistent with the previous studies [16, 17, 38]. …”

Section: Discussionsupporting

confidence: 94%

“…In our study, binary logistic regression analyses showed that only nodule type did not interfere with both CTR and SUV max . Our data were consistent with previous reports [16, 17], that mixed GGN was more common within IAC GGN. Recently, Kakinuma et al [35] found that at least a small portion (approximately 1%) of solitary pure GGNs within 5 mm will develop into IACs or MIAs appearing as solitary mixed GGNs.…”

Section: Discussionsupporting

confidence: 94%

“…Thereby, increased SUV max and CTR with mixed GGN may predict solitary GGNs developing into more invasive. There was significant difference of D GGN and D solid between IAC and AIS-MIA, which is consistent with previous study [17]. There was also markedly statistical significance of cystic appearance between IAC and AIS-MIA, it may be the reason that lung cancer has an association with cystic appearance [36] and especially there was significant difference in cystic appearance between pure GGN and mixed GGN [37].…”

Section: Discussionsupporting

confidence: 88%

“…With recent advancement of technology in multi-detector row CT (MDCT), it is possible to increasingly detect small GGN and to analyze its anatomic, morphologic, and quantitative information [9–17]. Based on the presence or absence of solid components, GGN is classified into mixed GGN and pure GGN on HRCT.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the presence or absence of solid components, GGN is classified into mixed GGN and pure GGN on HRCT. Although many studies have compared the morphologic appearances of different types of malignant GGNs [2, 12, 17–20], there is substantial overlap between benign GGNs and malignant GGNs [21]. Quantitative CT thus was established to evaluate GGN [9, 21, 22].…”

Section: Introductionmentioning

confidence: 99%

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Solitary ground-glass opacity nodules of stage IA pulmonary adenocarcinoma: combination of 18F-FDG PET/CT and high-resolution computed tomography features to predict invasive adenocarcinoma

Zhou

Zhang

et al. 2017

Oncotarget

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To investigate the performance of combined 18F-FDG Positron Emission Tomography/Computed Tomography with high-resolution CT for differentiating invasive adenocarcinoma from adenocarcinoma in situ (pre-invasive lesion) or minimally invasive adenocarcinoma in stage IA lung cancer patients with solitary ground-glass opacity nodules. This retrospective study enrolled 58 consecutive stage IA pulmonary adenocarcinoma patients with solitary ground-glass opacity nodules. The characteristics and measurements of the ground-glass opacity nodules as pure ground-glass opacity nodules and mixed ground-glass opacity nodules in the pre-invasive or minimally invasive adenocarcinoma and invasive adenocarcinoma groups on Positron Emission Tomography/Computed Tomography and high-resolution CT were compared and analyzed. Ground-glass opacity nodules in the pre-invasive or minimally invasive adenocarcinoma group preferentially manifested as pure ground-glass opacity nodule (p < 0.01) compared to the invasive adenocarcinoma group. While cystic appearance was more common in the invasive adenocarcinoma group (p < 0.05). Significant differences were found in the diameter of the ground-glass opacity nodule itself and its solid component, and consolidation/tumor ratio between the two groups. The sensitivity in predicting invasive adenocarcinoma was higher with a combined consolidation/tumor ratio > 0.38 and SUVmax > 1.46 in mixed ground-glass opacity nodule when compared to those of SUVmax > 0.95 alone or consolidation/tumor ratio> 0.39 alone (both p > 0.05). For a mixed ground-glass opacity nodule combined consolidation/tumor ratio > 0.38 and SUVmax > 1.46 appears to better predict invasive adenocarcinoma in stage IA lung cancer patients with solitary ground-glass opacity nodules.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Solitary ground-glass opacity nodules of stage IA pulmonary adenocarcinoma: combination of 18F-FDG PET/CT and high-resolution computed tomography features to predict invasive adenocarcinoma

Zhou

Zhang

et al. 2017

Oncotarget

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Chest

Jiang

Zhang

et al. 2020

Classic Imaging Signs

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Contents 4.1 Multinodule Accumulation Sign 4.2 Lobulation Sign 4.3 Spinous Protuberant Sign 4.4 Vacuole Sign 4.5 Coarse Spicules Sign 4.6 Pleural Indentation Sign 4.7 Beaded Septum Sign 4.8 Honeycomb Sign 4.9 Withered Tree Sign 4.10 CT Angiogram Sign 4.11 Air Bronchiologram Sign 4.12 Air Bronchogram 4.13 Positive Bronchus Sign 4.14 Mucous Bronchogram 4.15 Gloved Finger Sign 4.16 Feeding Vessel Sign 4.17 Vascular Convergence Sign 4.18 Silhouette Sign 4.19 Luftsichel Sign

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Subsolid pulmonary nodule morphology and associated patient characteristics in a routine clinical population

et al. 2016

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ObjectivesTo determine the presence and morphology of subsolid pulmonary nodules (SSNs) in a non-screening setting and relate them to clinical and patient characteristics.MethodsA total of 16,890 reports of clinically obtained chest CT (06/2011 to 11/2014, single-centre) were searched describing an SSN. Subjects with a visually confirmed SSN and at least two thin-slice CTs were included. Nodule volumes were measured. Progression was defined as volume increase exceeding the software interscan variation. Nodule morphology, location, and patient characteristics were evaluated.ResultsFifteen transient and 74 persistent SSNs were included (median follow-up 19.6 [8.3–36.8] months). Subjects with an SSN were slightly older than those without (62 vs. 58 years; p = 0.01), but no gender predilection was found. SSNs were mostly located in the upper lobes. Women showed significantly more often persistent lesions than men (94 % vs. 69 %; p = 0.002). Part-solid lesions were larger (1638 vs. 383 mm3; p < 0.001) and more often progressive (68 % vs. 38 %; p = 0.02), compared to pure ground-glass nodules. Progressive SSNs were rare under the age of 50 years. Logistic regression analysis did not identify additional nodule parameters of future progression, apart from part-solid nature.ConclusionsThis study confirms previously reported characteristics of SSNs and associated factors in a European, routine clinical population.Key Points• SSNs in women are significantly more often persistent compared to men.• SSN persistence is not associated with age or prior malignancy.• The majority of (persistent) SSNs are located in the upper lung lobes.• A part-solid nature is associated with future nodule growth.• Progressive solitary SSNs are rare under the age of 50 years.

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HRCT features distinguishing pre-invasive from invasive pulmonary adenocarcinomas appearing as ground-glass nodules

Abstract: • IACs appearing as GGNs were often ≥ 12.2 mm in diameter. • IACs were often ≥ 6.7 mm in solid component diameter. • The solid components of the IACs often exhibited ≥ -192 HU. • IACs exhibited air bronchogram more frequently than AIS-MIAs.

Cited by 72 publications

References 26 publications

Solitary ground-glass opacity nodules of stage IA pulmonary adenocarcinoma: combination of 18F-FDG PET/CT and high-resolution computed tomography features to predict invasive adenocarcinoma

Solitary ground-glass opacity nodules of stage IA pulmonary adenocarcinoma: combination of 18F-FDG PET/CT and high-resolution computed tomography features to predict invasive adenocarcinoma

Chest

Subsolid pulmonary nodule morphology and associated patient characteristics in a routine clinical population

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