HRS Facilitates Newcastle Disease Virus Replication in Tumor Cells by Promoting Viral Budding
Yu Chen,
Chunxuan Wang,
Shunlin Hu
et al.
Abstract:Newcastle disease virus (NDV) is a highly pathogenic avian infectious disease agent and also a promising oncolytic virus with broad application prospects. The Endosomal Sorting Complex Required for Transport (ESCRT) machinery has been increasingly recognized for its crucial role in the life cycles of enveloped viruses, influencing processes such as viral entry, replication, and budding. In this study, we employed an RNA interference screening approach to identify key ESCRT components that regulate NDV replicat… Show more
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