Hs-cTnT levels in professional soccer players throughout a season: No evidence of sustained cardiac damage

Sanchís-Gomar, Fabián; Alis, Rafael; Rampinini, Ermanno; Bosio, Andrea; Romagnoli, Marco; Lombardi, Giovanni; Lippi, Giuseppe

doi:10.1016/j.ijcard.2015.06.104

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Sanchis-Gomar, et al reported transient mild elevation of plasma cTnT levels in professional soccer players throughout a competitive season and recovery to normal conditions after the detraining period, which would reflect an adaptive response of cardiomyocytes to the physiological milieu. 46) In this study, the areas of cTnI positive immunoreactivity loss in myocardium were greater in group EE, which indicated the loss of cTnI in cardiomyocytes released into the circulation. Thus, the increase in cardiac troponin after prolonged exercise regarded as an adaptive response of cardiomyocytes to the physiological milieu is likely due to increased myocardial membrane permeability.…”

Section: Discussionsupporting

confidence: 51%

Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects

Wang

et al. 2019

Int. Heart J.

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The role of autophagy in the cardioprotection conferred by ischemic preconditioning (IPC) has been well described. This study aimed to investigate the changes in autophagy levels during the cardioprotective effects initiated by exercise preconditioning (EP).Rats were randomly divided into 4 groups: group C (control), group EP, group EE (exhaustive exercise), and group EP + EE (EP pretreatment at 0.5 hours before EE). The EP protocol included 4 periods of 10 minutes of treadmill running each at 30 m/minute with intervening 10 minute periods of rest. Hematoxylin-basic fuchsin-picric acid (HBFP) staining and plasma levels of cardiac troponin I (cTnI) were used to evaluate the ischemia-hypoxia injury in rat myocardium. Alteration levels in several autophagy proteins in the left ventricular myocardium were analyzed by Western blot. The phasic alterations of autophagy levels during EP-initiated cardioprotective phase were also examined.Compared with group C, the ischemia-hypoxia positive areas and IOD value in HBFP-staining and cTnI plasma levels increased significantly in group EE. Compared with group EE, the ischemia-hypoxia injury was markedly attenuated in group EP + EE. Compared with group C, the LC3-II/LC3-I ratio, a marker of autophagosome formation, was reduced in group EE, but the LC3-II/LC3-I ratio remained unaltered in group EP + EE. Furthermore, the LC3-II/LC3-I ratio increased significantly at 2 hours during the cardioprotective phase after EP.These results suggest that the activated autophagy level during the EP-initiated cardioprotective phase may be partly involved in the cardioprotective effects by maintaining a normal autophagy basal level during the subsequent exhaustive exercise in rat myocardium. (Int Heart J 2019; 60: 419-428)

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Section: Discussionsupporting

confidence: 51%

Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects

Wang

et al. 2019

Int. Heart J.

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Fabrication of Electrochemical Immunosensor for Cardiac Biomarker Troponin I Determination and Its Potential for Acute Myocardial Infarction Diagnosis

Li¹

2017

International Journal of Electrochemical Science

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The detection of cardiac troponin I (cTnl) at extremely low concentration was highly demanded since it was identified as a principal diagnostic marker for acute myocardial infarction. In this study, a composite of poly(diallyldimethylammonium chloride) (PDDA) and reduced graphene oxide (RGO) was successfully prepared and then employed for constructing immunosensors. The proposed immunosensor demonstrated excellent performance for the determination of cTnl with low detection limit (0.024 ng/mL) and wide linear response range (0.1-10 ng/mL). The proposed immunosensor has demonstrated promising potential in diagnose of acute myocardial infarction owing to the great deal of advantages such as remarkable sensitivity and reproducibility.

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Hs-cTnT levels in professional soccer players throughout a season: No evidence of sustained cardiac damage

Cited by 2 publications

References 10 publications

Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects

Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects

Fabrication of Electrochemical Immunosensor for Cardiac Biomarker Troponin I Determination and Its Potential for Acute Myocardial Infarction Diagnosis

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