Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1

Liu, Ruilei; Li, Jie; Lai, Yisheng; Liao, Yi; Liu, Ruiming; Qiu, Weiliang

doi:10.1016/j.ijbiomac.2015.08.016

Cited by 55 publications

(56 citation statements)

References 38 publications

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“…Abnormal expression of miRNAs has been involved in the initiation and progression of human cancer (10,11). The tumor suppressive function of miR-1 in cancer has been revealed in recent years (39,(43)(44)(45). Downregulation of miR-1 was shown to enhance the tumorigenesis and invasiveness of oral squamous cell carcinoma (46).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells

Yang

Ding

et al. 2018

Oncol Rep

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Pituitary tumors are generally intracranial neoplasms with high incidence and mortality rates. The investigation of novel factors involved in the tumorigenesis of pituitary tumors and the characterization of the underlying molecular mechanisms is urgently required for the diagnosis and treatment of pituitary tumors. Accumulating evidence has indicated that microRNAs (miRs) serve important roles in the initiation and progression of cancer. The present study found that miR-1 was significantly downregulated in pituitary tumor tissues upon reverse transcription-quantitative polymerase chain reaction analysis. Decreased expression of miR-1 was associated with the progression and worse prognosis of patients with pituitary tumors. The MTT assay showed that overexpression of miR-1 significantly suppressed proliferation. Highly expressed miR-1 promoted the apoptosis of pituitary tumor cells upon fluorescence-activated cell sorting analysis. Further molecular study revealed that glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the pentose phosphate pathway (PPP), was one of the targets of miR-1. Western blot assays showed that overexpression of miR-1 significantly decreased the protein level of G6PD in pituitary tumor cells without changing the mRNA level of G6PD. Consequently, oxidative PPP flux analysis revealed that suppression of G6PD by miR-1 decreased the production of nicotinamide adenine dinucleotide phosphate and the glycolysis of pituitary cancer cells. Restoration of the expression of G6PD significantly reversed the inhibitory effect of miR-1 on the PPP and the growth of pituitary tumor cells. Collectively, the present results uncovered the critical involvement of miR-1 in pituitary tumors, indicating that miR-1 is a potential therapeutic target for the treatment of pituitary tumors.

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Section: Discussionmentioning

confidence: 99%

Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells

Yang

Ding

et al. 2018

Oncol Rep

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“…In the case of CDC42, it is a member of Rho protein families with GTPase activity, that is abnormally involved in BC by regulation of cell apoptosis, proliferation, and cell migration through CDC42/RAC1‐PAK1‐Erk1/2 and RhoA/CDC42/p‐ERM pathways (Halon, Donizy, Surowiak, & Matkowski, ). It should be noted that the miR‐1 also shows tumor suppressor function in BC (Beltran et al, ; R. Liu et al, ) and other various tumors (Kawakami et al, ; Letelier et al, ; D. Li, Liu, et al, ; Mataki et al, ; C.‐D. Wu, Kuo, Wu, & Lin, ).…”

Section: Cerna Interplay In Bc Development and Pathogenesismentioning

confidence: 99%

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

Abdollahzadeh

Daraei

Mansoori

et al. 2018

Journal Cellular Physiology

231

185

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Breast cancer (BC) is the most frequently occurring malignancy in women worldwide. Despite the substantial advancement in understanding the molecular mechanisms and management of BC, it remains the leading cause of cancer death in women. One of the main reasons for this obstacle is that we have not been able to find the Achilles heel for the BC as a highly heterogeneous disease. Accumulating evidence has revealed that noncoding RNAs (ncRNAs), play key roles in the development of BC; however, the involving of complex regulatory interactions between the different varieties of ncRNAs in the development of this cancer has been poorly understood. In the recent years, the newly discovered mechanism in the RNA world is “competing endogenous RNA (ceRNA)” which proposes regulatory dialogues between different RNAs, including long ncRNAs (lncRNAs), microRNAs (miRNAs), transcribed pseudogenes, and circular RNAs (circRNAs). In the latest BC research, various studies have revealed that dysregulation of several ceRNA networks (ceRNETs) between these ncRNAs has fundamental roles in establishing the hallmarks of BC development. And it is thought that such a discovery could open a new window for a better understanding of the hidden aspects of breast tumors. Besides, it probably can provide new biomarkers and potential efficient therapeutic targets for BC. This review will discuss the existing body of knowledge regarding the key functions of ceRNETs and then highlights the emerging roles of some recently discovered ceRNETs in several hallmarks of BC. Moreover, we propose for the first time the “ceRnome” as a new term in the present article for RNA research.

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“…MALAT‐1 and KRas have shown to be new targets for miR‐1. High expression of miR‐1 restrains tumor growth and metastasis by negative control of KRas and MALAT1 in breast tumor cells (Liu, Li et al, ). P21‐activated kinase 4 (PAK4) performs an important function through the Raf/MEK/ERK pathway in breast tumor metastasis.…”

Section: Crosstalk Between Various Signaling Pathways and Mirnas In Bmentioning

confidence: 99%

MicroRNAs in breast cancer: Roles, functions, and mechanism of actions

Abolghasemi

Tehrani

Yousefi

et al. 2019

Journal Cellular Physiology

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Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.

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Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1

Cited by 55 publications

References 38 publications

Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells

Downregulation of glucose‑6‑phosphate dehydrogenase by microRNA‑1 inhibits the growth of pituitary tumor cells

Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: A new look at hallmarks of breast cancer

MicroRNAs in breast cancer: Roles, functions, and mechanism of actions

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