Hsa‐miR‐125b suppresses bladder cancer development by down‐regulating oncogene SIRT7 and oncogenic long non‐coding RNA MALAT1

Han, Yonghua; Liu, Yuchen; Zhang, Hu; Wang, Tiantian; Diao, Ruiying; Jiang, Ziyu; Gui, Yaoting; Cai, Zhiming

doi:10.1016/j.febslet.2013.10.023

Cited by 160 publications

(125 citation statements)

References 21 publications

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“…In recent years, emerging studies have been performed on SIRT7 and provided some potential mechanisms for SIRT7 in promoting cancer development. Researches in hepatocelluar carcinoma and bladder cancer indicated that SIRT7 promoted cancer cell proliferation and was regulated by microRNA, such as miR-125a-5p and miR-125b; a research in colorectal cancer identified that SIRT7 functioned as an oncogene by activation of RAF-MEK-ERK signaling pathway and increased cancer cells motility by epithelial-tomesenchymal transition (EMT) (Han et al, 2013;Kim et al, 2013;Yu et al, 2014). However, the level of SIRT7 in ovarian malignancies and the corresponding consequences of its aberrant regulation have not been discovered.…”

Section: Discussionmentioning

confidence: 99%

“…Another study proposed that SIRT7 can promote cell survival by suppressing ER stress in a myc-dependent mannner (Shin et al, 2013). In addition, evidence has suggested that SIRT7 was related to maintenance of cellular transformation in malignancies, such as breast, liver, bladder and colorectal cancer; it has an elevated level in cancerous tissues compared with the noncancerous and its levels are associated with tumor progression (Ashraf et al, 2006;Han et al, 2013;Kim et al, 2013;Yu et al, 2014). On the contrary, a comprehensive research on the expression level of SIRT7 in head and neck squamous cell carcinoma showed a significant down-regulation (Lai et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells

Wang

Xie

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form (NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is implicated in various processes, such as aging, DNA damage repair and cell signaling transduction. There is some evidence that SIRT7 may function as a tumor trigger for human malignancy. Here, we aimed to explore the biological function of SIRT7 in ovarian carcinoma cells and its potential mechanism. Materials and Methods: Expression of SIRT7 in ovarian cancer cell lines was detected by western blotting. Transduced cell lines with SIRT7 knockdown or overexpression were constructed. Cell viability, cologenic, apoptosis-associated and motility assays were performed to elucidate the biological function of SIRT7 in ovarian cancer cells. Results: SIRT7 demonstrated a higher level in ovarian cancer cell lines compared with normal cells. On the one hand, down-regulation of SIRT7 significantly reduced ovarian cancer cell growth, repressed colony formation and increased cancer cell apoptosis; on the other hand, up-regulation promoted the migration of cancer cells. Additionally, repression of SIRT7 also induced change in apoptosis-related molecules and subunits of the NF-κB family. Conclusions: In the present study, our data indicated that SIRT7 might play a role of oncogene in ovarian malignancy and be a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells

Wang

Xie

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…For example, in bladder cancer, miR-125b inhibited cell proliferation and motility, and enhanced cell apoptosis by regulating the expression of nicotinamide-adenine dinucleotide-dependent protein deacetylase sirtuin-7 and matrix metalloproteinase-13 (22,28). Furthermore, miR-125b decreased bladder cancer cell colony formation efficiency in vitro and the development of tumors in nude mice by targeting transcription factor E2F3 (18).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility

et al. 2017

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Abstract.A majority of studies have indicated that microRNA-125b (miR-125b) is aberrantly expressed in various types of cancer. However, there are no studies on the expression and function of miR-125b in human laryngeal squamous cell carcinoma (LSCC). In the present study, miR-125b expression in LSCC sample tissues, corresponding adjacent non-neoplastic tissues, LSCC cell lines and a normal human keratinocyte cell line was measured using the reverse transcription-quantitative polymerase chain reaction. Following transfection with miR-125b mimics, the Cell Counting Kit-8, cell migration, cell invasion, western blotting and dual-luciferase reporter assays were performed on LSCC cell lines. According to the results, miR-125b was observed to be significantly downregulated in LSCC, and its expression was significantly associated with clinical stage and alcohol history. miR-125b was also observed to decrease cell growth, migra tion and invasion in LSCC cells by directly targeting signal transducer and activator of transcription 3. The results of the present study suggested that miR-125b may be a potential treatment target of LSCC in the future.

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“…In addition, miR-9 may target AGO2-mediated regulation of MALAT-1 in the nucleus (67). Han et al hypothesized that Hsa-miR-125b is downregulated in bladder cancer compared with matched normal urothelium (68). However, sirtuin (SIRT)7 and MALAT-1 were upregulated in bladder cancer compared with matched normal urothelium.…”

Section: Malat-1 and Epigenetic Regulationmentioning

confidence: 99%

Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications

Ren

et al. 2016

Oncology Letters

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Abstract. Long non-protein-coding RNAs (lncRNAs) are emerging as important gene expression regulators that are linked to various biological processes at the post-transcriptional and transcriptional levels. lncRNAs are known to be important in cell proliferation, cell differentiation, apoptosis and metastasis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a novel lncRNA, is highly conserved amongst mammals. In addition, it has been considered to act as an oncogene, depending on the tumor system. An increasing number of studies have indicated that MALAT-1 may be detected in certain types of human tumors, including lung and bladder cancer and hepatocellular carcinoma. MALAT-1 silencing may be an effective therapeutic approach against tumors. The present study reviews the current knowledge on the functional role of MALAT-1 in the control of various cancers.

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Hsa‐miR‐125b suppresses bladder cancer development by down‐regulating oncogene SIRT7 and oncogenic long non‐coding RNA MALAT1

Cited by 160 publications

References 21 publications

SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells

SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells

MicroRNA-125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility

Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications

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