Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors

Pasculli, Barbara; Barbano, Raffaela; Fontana, Andrea; Biagini, Tommaso; Viesti, Maria Pia Di; Rendina, Michelina; Valori, Vanna Maria; Morritti, Maria; Bravaccini, Sara; Ravaioli, Sara; Maiello, Evaristo; Graziano, Paolo; Murgo, Roberto; Copetti, Massimiliano; Mazza, Tommaso; Fazio, Vito Michele; Esteller, Manel; Parrella, Paola

doi:10.3389/fonc.2020.01415

Cited by 39 publications

(30 citation statements)

References 66 publications

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“…In breast cancer, the oncomir miR-155-5p was found mostly upregulated and associated with a more aggressive type and worse outcome (122). The combined treatment with Olaparib, an inhibitor of PARP1, with miR-155-5p ectopic overexpression was found a great combination to induce lethal effect to reduce cancer cells viability (123) Further investigation of PARPs as a biomarker for novel cancer therapies is needed.…”

Section: Parylation Post-translational Modification Affect Mirna Actimentioning

confidence: 99%

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

et al. 2020

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microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They target more than one mRNAs, thus influencing multiple molecular pathways, but also mRNAs may bind to a variety of miRNAs, either simultaneously or in a context-dependent manner. miRNAs biogenesis, including miRNA transcription, processing by Drosha and Dicer, transportation, RISC biding, and miRNA decay, are finely controlled in space and time.miRNAs are critical regulators in various biological processes, such as differentiation, proliferation, apoptosis, and development in both health and disease. Their dysregulation is involved in tumor initiation and progression. In tumors, they can act as onco-miRNAs or oncosuppressor-miRNA participating in distinct cellular pathways, and the same miRNA can perform both activities depending on the context.In tumor progression, the angiogenic switch is fundamental. miRNAs derived from tumor cells, endothelial cells, and cells of the surrounding microenvironment regulate tumor angiogenesis, acting as pro-angiomiR or anti-angiomiR.In this review, we described miRNA biogenesis and function, and we update the non-classical aspects of them. The most recent role in the nucleus, as transcriptional gene regulators and the different mechanisms by which they could be dysregulated, in tumor initiation and progression, are treated. In particular, we describe the role of miRNAs in sprouting angiogenesis, vessel co-option, and vasculogenic mimicry. The role of miRNAs in lymphoma angiogenesis is also discussed despite the scarcity of data.The information presented in this review reveals the need to do much more to discover the complete miRNA network regulating angiogenesis, not only using high-throughput computational analysis approaches but also morphological ones.

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Section: Parylation Post-translational Modification Affect Mirna Actimentioning

confidence: 99%

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

et al. 2020

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“…Without patient-level data, it would be very difficult to tell whether miR-155 is actually useful as a marker in early detection of BC. Besides, BRCA1-deficient tumors have been shown to have increased levels of miR-155, which could be relevant for identifying possible respondents to PARP-1 inhibitors [ 55 , 56 ]. Most of the mechanistic studies on miR-155 and BC have been done on these patients, which was ignored in this study.…”

Section: Discussionmentioning

confidence: 99%

Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer

et al. 2021

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Background MicroRNA-155 (miR-155) may function as a diagnostic biomarker of breast cancer (BC). Nevertheless, the available evidence is controversial. Therefore, we performed this study to summarize the global predicting role of miR-155 for early detection of BC and preliminarily explore the functional roles of miR-155 in BC. Methods We first collected published studies and applied the bivariate meta-analysis model to generate the pooled diagnostic parameters of miR-155 in diagnosing BC such as sensitivity, specificity and area under curve (AUC). Then, we applied function enrichment and protein–protein interactions (PPI) analyses to explore the potential mechanisms of miR-155. Results A total of 21 studies were finally included. The results indicated that miR-155 allowed for the discrimination between BC patients and healthy controls with a sensitivity of 0.87 (95% CI 0.78–0.93), specificity of 0.82 (0.72–0.89), and AUC of 0.91 (0.88–0.93). In addition, the overall sensitivity, specificity and AUC for circulating miR-155 were 0.88 (0.76–0.95), 0.83 (0.72–0.90), and 0.92 (0.89–0.94), respectively. Function enrichment analysis revealed several vital ontologies terms and pathways associated with BC occurrence and development. Furthermore, in the PPI network, ten hub genes and two significant modules were identified to be involved in some important pathways associated with the pathogenesis of BC. Conclusions We demonstrated that miR-155 has great potential to facilitate accurate BC detection and may serve as a promising diagnostic biomarker for BC. However, well-designed cohort studies and biological experiments should be implemented to confirm the diagnostic value of miR-155 before it can be applied to routine clinical procedures.

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“…The top hit in correlated miRNAs, mir−155, is a known oncogenic microRNA that targets the ELK3 transcription factor that is imperative in the response to hypoxia [ 17 ]. It was shown to be upregulated in breast cancer and linked to PARP-1 inhibitors response [ 18 ]. In bladder cancer, this miR is known to be significantly overexpressed, promoting tumour growth by repressing DMTF1, a tumour-supressing gene [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Correlations in the Expression of miRNA Genes and Immune Checkpoint Genes in Bladder Cancer Cells

Stempor

Avni

Leibowitz

et al. 2021

IJMS

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Personalised medicine is the future and hope for many patients, including those with cancers. Early detection, as well as rapid, well-selected treatment, are key factors leading to a good prognosis. MicroRNA mediated gene regulation is a promising area of development for new diagnostic and therapeutic methods, crucial for better prospects for patients. Bladder cancer is a frequent neoplasm, with high lethality and lacking modern, advanced therapeutic modalities, such as immunotherapy. MicroRNAs are involved in bladder cancer pathogenesis, proliferation, control and response to treatment, which we summarise in this perspective in response to lack of recent review publications in this field. We further performed a correlation-based analysis of microRNA and gene expression data in bladder cancer (BLCA) TCGA dataset. We identified 27 microRNAs hits with opposite expression profiles to genes involved in immune response in bladder cancer, and 24 microRNAs hits with similar expression profiles. We discuss previous studies linking the functions of these microRNAs to bladder cancer and assess if they are good candidates for personalised medicine therapeutics and diagnostics. The discussed functions include regulation of gene expression, interplay with transcription factors, response to treatment, apoptosis, cell proliferation and angiogenesis, initiation and development of cancer, genome instability and tumour-associated inflammatory reaction.

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Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors

Cited by 39 publications

References 66 publications

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer

Comprehensive Analysis of Correlations in the Expression of miRNA Genes and Immune Checkpoint Genes in Bladder Cancer Cells

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