Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy

Lin, Jiajie; Chen, Rui; Yang, Liyun; Gong, Miao; Du, Mei-Yang; Mu, Shiqing; Jiang, Ze-An; Li, Huanhuan; Yang, Yang; Wang, Xinghui; Wang, Sifan; Liu, Kexin; Cao, Shan-Hu; Wang, Zhaoyi; Zhao, Anqi; Yang, Songbai; Cheng, Li; Sun, Shao-Guang

doi:10.1016/j.jare.2023.07.010

Cited by 7 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CircTBC1D1 (hsa_circ_0001402) promoted FKBPL expression by targeting miR-183-5p to suppress VSMC proliferation and migration. Additionally, circTBC1D1 enhanced VSMC autophagy by binding with miR-183-5p to increase BECN1 levels (82).…”

Section: Smc-related Circrnasmentioning

confidence: 98%

Circular RNAs in vascular diseases

Liu,

Wang,

Zhang

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Vascular diseases are the leading cause of morbidity and mortality worldwide and are urgently in need of diagnostic biomarkers and therapeutic strategies. Circular RNAs (circRNAs) represent a unique class of RNAs characterized by a circular loop configuration and have recently been identified to possess a wide variety of biological functions. CircRNAs exhibit exceptional stability, tissue specificity, and are detectable in body fluids, thus holding promise as potential biomarkers. Their encoding function and stable gene expression also position circRNAs as an excellent alternative to gene therapy. Here, we briefly review the biogenesis, degradation, and functions of circRNAs. We summarize circRNAs discovered in major vascular diseases such as atherosclerosis and aneurysms, with a particular focus on molecular mechanisms of circRNAs identified in vascular endothelial cells and smooth muscle cells, in the hope to reveal new directions for mechanism, prognosis and therapeutic targets of vascular diseases.

show abstract

Section: Smc-related Circrnasmentioning

confidence: 98%

Circular RNAs in vascular diseases

Liu,

Wang,

Zhang

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Histone H3K9 acetylation was significantly increased in the lungs of PH patients and promoted PASMC proliferation via Sphingosine Kinase 2 [18]. CircRNA, Hsa_circ_0001402 acts as an miR-183-5p sponge to inhibit SMC proliferation and migration while activating VSMC autophagy to alleviate neointimal hyperplasia [19]. Another SMC epigenetic target is SETD2; the main enzyme that catalyzes the trimethylation of H3K36 (H3K36me3) as SMCs-specific SETD2 deficiency ameliorated the pathological pulmonary vascular remodeling in a hypoxia-induced mouse model of PH [20].…”

Section: Smooth Muscle Cellsmentioning

confidence: 99%

Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension

Ranasinghe,

Tennakoon,

Schwarz

2024

Cells

View full text Add to dashboard Cite

Pulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations that contribute to the molecular and morphological changes of PH in conjunction with current animal models for studying vascular remodeling in PH will be examined. The status quo of epigenetic targeting for treating vascular remodeling in different PH subtypes will be dissected, while parallel epigenetic threads between pulmonary hypertension and pathogenic cancer provide insight into future therapeutic PH opportunities.

show abstract