Hsa_circ_0001550 impairs decidualization by regulating the proliferation and apoptosis of endometrial stromal cells

Lyu, Meng; Gao, Wenxin; Zhang, Lili; Yang, Xiaobo; Yue, Feng Yun; Li, Hongxing; Ma, Xiaoling; Liu, Lin

doi:10.1016/j.rbmo.2022.10.003

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…Decidualization of the maternal endometrium is necessary for successful implantation and embryo development. Specialized DSCs are produced through the differentiation and transformation of ESCs [ 98 ]. DSCs contribute to immune tolerance by stimulating dNK cells to produce Th2 cytokines, such as IL-4, IL-13, and IL-10 [ 99 ].…”

Section: Involvement Of Rcd At the Maternal-fetal Interface In Pregnancymentioning

confidence: 99%

The regulated cell death at the maternal-fetal interface: beneficial or detrimental?

Chen,

Zheng

2024

Cell Death Discov.

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Regulated cell death (RCD) plays a fundamental role in placental development and tissue homeostasis. Placental development relies upon effective implantation and invasion of the maternal decidua by the trophoblast and an immune tolerant environment maintained by various cells at the maternal-fetal interface. Although cell death in the placenta can affect fetal development and even cause pregnancy-related diseases, accumulating evidence has revealed that several regulated cell death were found at the maternal-fetal interface under physiological or pathological conditions, the exact types of cell death and the precise molecular mechanisms remain elusive. In this review, we summarized the apoptosis, necroptosis and autophagy play both promoting and inhibiting roles in the differentiation, invasion of trophoblast, remodeling of the uterine spiral artery and decidualization, whereas ferroptosis and pyroptosis have adverse effects. RCD serves as a mode of communication between different cells to better maintain the maternal-fetal interface microenvironment. Maintaining the balance of RCD at the maternal-fetal interface is of utmost importance for the development of the placenta, establishment of an immune microenvironment, and prevention of pregnancy disorders. In addition, we also revealed an association between abnormal expression of key molecules in different types of RCD and pregnancy-related diseases, which may yield significant insights into the pathogenesis and treatment of pregnancy-related complications.

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Section: Involvement Of Rcd At the Maternal-fetal Interface In Pregnancymentioning

confidence: 99%

The regulated cell death at the maternal-fetal interface: beneficial or detrimental?

Chen,

Zheng

2024

Cell Death Discov.

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Identification of Differentially Expressed mRNAs and lncRNAs Contributes to Elucidation of Underlying Pathogenesis and Therapeutic Strategy of Recurrent Implantation Failure

Liu,

Tian

et al. 2024

Reprod. Sci.

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Comment on: “Circular RNA circ-3626 promotes bone formation by modulating the miR-338-3p/Runx2 axis” by Chen et al., Joint Bone Spine 2024;91:105669

Zhang,

Kong,

Zhou

2025

Joint Bone Spine

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Hsa_circ_0001550 impairs decidualization by regulating the proliferation and apoptosis of endometrial stromal cells

Cited by 4 publications

References 37 publications

The regulated cell death at the maternal-fetal interface: beneficial or detrimental?

The regulated cell death at the maternal-fetal interface: beneficial or detrimental?

Identification of Differentially Expressed mRNAs and lncRNAs Contributes to Elucidation of Underlying Pathogenesis and Therapeutic Strategy of Recurrent Implantation Failure

Comment on: “Circular RNA circ-3626 promotes bone formation by modulating the miR-338-3p/Runx2 axis” by Chen et al., Joint Bone Spine 2024;91:105669

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