hsa_circ_0001955 Promotes Colorectal Cancer Progression by Regulating miR-583/FGF21 Axis

Gao, Xuefeng; Yin, Jing; Yao, Ying

doi:10.1155/2022/4288474

Cited by 8 publications

(6 citation statements)

References 33 publications

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“…Moreover, with the cooperation of other non-coding RNAs like circular RNAs, miR-583 hinders tumoral cells’ growth. Suppressing miR-583 through hsa_circ_0001955/miR-583/FGF21 axis promotes colorectal cancer [ 45 ]. These observations suggest miR-877-5p and miR-583 as tumor suppressors in cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of miR-583 and mir-877-5p as biomarkers in patients with breast cancer: an integrated experimental and bioinformatics research

et al. 2023

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Objectives Breast cancer (BC) is one of the most common cancers with a high mortality rate in women worldwide. The advantages of early cancer diagnosis are apparent, and it is a critical factor in increasing the patient’s life and survival. According to mounting evidence, microRNAs (miRNAs) may be crucial regulators of critical biological processes. miRNA dysregulation has been linked to the beginning and progression of various human malignancies, including BC, and can operate as tumor suppressors or oncomiRs. This study aimed to identify novel miRNA biomarkers in BC tissues and non-tumor adjacent tissues of patients with BC. Microarray datasets GSE15852 and GSE42568 for differentially expressed genes (DEGs) and GSE45666, GSE57897, and GSE40525 for differentially expressed miRNAs (DEMs) retrieved from the Gene Expression Omnibus (GEO) database were analyzed using “R” software. A protein-protein interaction (PPI) network was created to identify the hub genes. MirNet, miRTarBase, and MirPathDB databases were used to predict DEMs targeted genes. Functional enrichment analysis was used to demonstrate the topmost classifications of molecular pathways. The prognostic capability of selected DEMs was evaluated through a Kaplan-Meier plot. Moreover, the specificity and sensitivity of detected miRNAs to discriminate BC from adjacent controls were assessed by area under the curve (AUC) using the ROC curve analysis. In the last phase of this study, gene expression on 100 BC tissues and 100 healthy adjacent tissues were analyzed and calculated by using the Real-Time PCR method. Results This study declared that miR-583 and miR-877-5p were downregulated in tumor samples in comparison to adjacent non-tumor samples (|logFC|< 0 and P ≤ 0.05). Accordingly, ROC curve analysis demonstrated the biomarker potential of miR-877-5p (AUC = 0.63) and miR-583 (AUC = 0.69). Our results showed that has-miR-583 and has-miR-877-5p could be potential biomarkers in BC.

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Section: Discussionmentioning

confidence: 99%

Identification and validation of miR-583 and mir-877-5p as biomarkers in patients with breast cancer: an integrated experimental and bioinformatics research

et al. 2023

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“… 24 , 25 , 26 Of these, circRNA has been most extensively investigated as a “molecular sponge” for miRNAs that regulate miRNA expression and thus participate in tumor progression. For example, hsa_circ_0003258 promotes PCa progression via miR‐653‐5p, 27 hsa_circ_0001955 promotes malignant metastasis of colorectal cancer cells via miR‐583, 28 and circSTX6 promotes pancreatic ductal adenocarcinoma proliferation via miR‐449b‐5p. 29 Through a bioinformatic approach, we identified hsa_circ_0070512 as a “molecular sponge” for miR‐338‐3p.…”

Section: Discussionmentioning

confidence: 99%

has_circ_0070512 promotes prostate cancer progression by regulating the miR‐338‐3p/hedgehog signaling pathway

et al. 2022

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Circular RNAs (circRNAs) are a type of non‐coding RNA that plays a vital role in biology. circRNAs appear to have a role in the development and progression of several malignancies, according to research. However, circRNAs that regulate prostate cancer (PCa) progression are still largely unknown and deserve further exploration. The aim of this study was to investigate the effect of hsa_circ_0070512 on the function and mechanism of PCa. hsa_circ_0070512 was increased in PCa tissues and cells and was mostly found in the cytoplasm of PCa cells. Overexpression of hsa_circ_0070512 considerably increased PCa cell proliferation and migration, whereas silencing of hsa_circ_0070512 greatly decreased PCa cell proliferation and migration. Mechanistically, we show that hsa_circ_0070512 acts as a “molecular sponge” for miR‐338‐3p and that the miR‐338‐3p mimics partially block the pro‐tumor effects of hsa_circ_0070512. RNA sequencing analysis of PC3 cells stably overexpressing hsa_circ_0070512 revealed that hedgehog was downstream of the signaling pathways of hsa_circ_0070512 and miR‐338‐3p. Our results implied that hsa_circ_0070512 regulated the hedgehog signaling pathways through miR‐338‐3p to enhance PCa growth and migration, providing a new diagnostic and therapeutic target for PCa.

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“… [ 148 ] Circ_0001955 hsa_circ_0001955 Up Tissues miR-583 Promotes tumor growth. [ 149 ] CircFAT1 hsa_circ_0001461 Up Tissues miR-619-5p Promotes migration, invasion, and angiogenesis. [ 150 ] CircLHFPL2 hsa_circ_7431 Up Tissues miR-556-5p/1322 Promotes CRC progression.…”

Section: Dysregulation Of Circrna In Crcmentioning

confidence: 99%

CircRNAs in colorectal cancer: potential biomarkers and therapeutic targets

Zhang

Luo²,

et al. 2023

Cell Death Dis

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Globally, colorectal cancer (CRC) is the third most prevalent cancer and the second leading cause of cancer-related deaths. Circular RNAs (circRNAs) are single-stranded RNA with covalently closed-loop structures and are highly stable, conserved, and abundantly expressed in various organs and tissues. Recent research found abnormal circRNA expression in CRC patients’ blood/serum, cells, CRC tissues, and exosomes. Furthermore, mounting data demonstrated that circRNAs are crucial to the development of CRC. CircRNAs have been shown to exert biological functions by acting as microRNA sponges, RNA-binding protein sponges, regulators of gene splicing and transcription, and protein/peptide translators. These characteristics make circRNAs potential markers for CRC diagnosis and prognosis, potential therapeutic targets, and circRNA-based therapies. However, further studies are still necessary to improve the understanding of the roles and biological mechanisms of circRNAs in the development of CRC. In this review, up-to-date research on the role of circRNAs in CRC was examined, focusing on their potential application in CRC diagnosis and targeted therapy, which would advance the knowledge of the functions of circRNAs in the development and progression of CRC.

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hsa_circ_0001955 Promotes Colorectal Cancer Progression by Regulating miR-583/FGF21 Axis

Cited by 8 publications

References 33 publications

Identification and validation of miR-583 and mir-877-5p as biomarkers in patients with breast cancer: an integrated experimental and bioinformatics research

Identification and validation of miR-583 and mir-877-5p as biomarkers in patients with breast cancer: an integrated experimental and bioinformatics research

has_circ_0070512 promotes prostate cancer progression by regulating the miR‐338‐3p/hedgehog signaling pathway

CircRNAs in colorectal cancer: potential biomarkers and therapeutic targets

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