Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma

Li, Bowen; Wang, Feng; Li, Xiang; Sun, Shuai; Shen, Yuehong; Yang, Hongyu

doi:10.1155/2018/7496890

Cited by 45 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As one of the most widely studied functions of cir-cRNAs as miRNA sponges in the cytoplasm 29,30 , several circRNA-miRNA interplays have been shown to critically contribute to OSCC initiation and progression. For instance, hsa_circ_0008309 was firstly explored to suppress miR-136-5p and miR-382-5p expression and enhance ATXN1 expression in OSCC cells 17 . circDOCK1 was also enhanced in OSCC and suppressed cell apoptosis by functioning as ceRNA for the miR-196-5a 31 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the involvement of the circRNA-miRNA-mRNA signaling axis in OSCC development and progression has been established 16 . Of note, hsa_-circ_0008309 inhibits miR-136-5p and miR-382-5p expression and augments ATXN1 expression in OSCC 17 . circRNA_100290, on the other hand, functions as a competing endogenous RNA (ceRNA), which regulates other RNA transcripts by competing for shared microRNAs (miRNAs), to antagonize miR-378a-driven GLUT1 suppression, finally leading to the induction of glycolysis and cell proliferation in OSCC 18 .…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

et al. 2020

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. Circular RNA (circRNA) has been increasingly recognized as a crucial contributor to carcinogenesis. circRNA_0000140 has been aberrantly expressed in OSCC, but its role in tumor growth and metastasis remains largely unclear. Sanger sequencing, actinomycin D, and RNase R treatments were used to confirm head-to-tail junction sequences and the stability of circ_0000140. In vitro cell activities, including proliferation, migration, invasion, and apoptosis, were determined by colony formation, transwell, and flow cytometry assays. The expression levels of circ_0000140, Hippo signaling pathway, and serial epithelial-mesenchymal transition (EMT) markers were measured by quantitative real-time PCR, western blotting, immunofluorescence, and immunohistochemistry. Dual luciferase reporter assays and Argonaute 2-RNA immunoprecipitation assays were performed to explore the interplay among circ_0000140, miR-31, and LATS2. Subcutaneous tumor growth was observed in nude mice, in which in vivo metastasis was observed following tail vein injection of OSCC cells. circ_0000140 is derived from exons 7 to 10 of the KIAA0907 gene. It was down-regulated in OSCC tissues and cell lines, and correlated negatively with poor prognostic outcomes in OSCC patients. Gain-offunction experiments demonstrated that circ_0000140 enhancement suppressed cell proliferation, migration, and invasion, and facilitated cell apoptosis in vitro. In xenograft mouse models, overexpression of circ_0000140 was able to repress tumor growth and lung metastasis. Furthermore, mechanistic studies showed that circ_0000140 could bind with miR-31 and up-regulate its target gene LATS2, thus affecting OSCC cellular EMT. Our findings demonstrated the roles of circ_0000140 in OSCC tumorigenesis as well as in metastasis, and circ_0000140 exerts its tumor-suppressing effect through miR-31/LATS2 axis of Hippo signaling pathway in OSCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In addition, hsa_circ_0014717 inhibits CRC growth, possibly by upregulating P16 expression . By regulating miR‐136‐5p/ATXN1 and miR‐382‐5p/ATXN1 networks, hsa_circ_0008309 regulates cell proliferation and EMT in various cancers . In addition, circ004389 may be a target of histone H3 and BMI1 proto‐oncogene in esophageal cancer.…”

Section: Tumor‐suppressive Circrnas and Cancersmentioning

confidence: 99%

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

et al. 2019

View full text Add to dashboard Cite

internal ribosome entry site; LARP4, La-related protein 4; LATS1, large tumor suppressor kinase 1; lncRNAs, long noncoding RNAs; MIBC, muscle invasive bladder cancer; miRNA, microRNA; ncRNAs, noncoding RNAs; NF1, neurofibromin 1; Notch1, notch homolog 1; NSCLC, non-small cell lung cancer; OS, overall survival; PCK1, phosphoenolpyruvate carboxykinase 1; PDAC, pancreatic ductal adenocarcinoma; RBP, RNA-binding protein; RCAN1, regulation of Down syndrome critical region gene 1; sncRNAs, short noncoding RNAs; TIMP3, metalloproteinase inhibitor 3; USP28, ubiquitin-specific peptidase 28; YBX1, Y box binding protein 1. AbstractCircular RNAs (circRNAs) have a covalently closed circular conformation and are structurally stable. Those circRNAs with tumor-suppressive properties play an important role in tumorigenesis and metastasis and thus may be used as therapeutic targets of cancers. Herein, we review the current understanding of the classification of circRNAs and summarize the functions and mechanisms of circRNAs that have tumor-suppressive roles in various cancers, including liver cancer (circARSP91, circ-ADAMTS13, circADAMTS14, circMTO1, hsa_circ_0079299, and circC3P1), bladder cancer (circFNDC3B, circITCH, circHIPK3, circRNA-3, cdrlas, and circLPAR1), gastric cancer (circLARP4, circYAP1, hsa_cric_0000096, hsa_circ_0000993, and circPSMC3), breast cancer (circ_000911, hsa_circ_0072309, and circASS1), lung cancer (hsa_ circ_0000977, circPTK2, circ_0001649, hsa_circ_100395, and circ_0006916), glioma (circ_0001946, circSHPRH, and circFBXW7), and colorectal cancer (circITGA7 and hsa_circ_0014717). Thanks to their structural stability, these tumor-suppressive cir-cRNAs may be used as potential and potent therapeutic targets. Moreover, we propose a new method for the classification of circRNAs. Based on whether they can be translated, circRNAs can be divided into noncoding circRNAs and coding circRNAs. K E Y W O R D Sbiogenesis, cancer, circular RNA, mechanism, therapeutic target | INTRODUC TI ONThose RNAs that do not encode proteins are called ncRNAs. 1 Regulatory ncRNAs are divided into lncRNAs and sncRNAs. LncRNAs can be linear or circular. 2 Circular RNAs were first discovered in 1976. 3 Since then, a variety of circRNAs have been discovered. 4,5 CircRNAs are more resistant to exonuclease and are more stable than other lncRNAs. 3,6 They exist in exosomes and plasma. 6,7 Li et al identified more than 1000 circRNAs in human serum exosomes. 6 Li et al found 343 differentially How to cite this article:

show abstract

“…Researchers identified that some candidate circRNAs can serve as biomarkers for the prostate cancer and were able to detect circRNAs in the urine . Another study revealed that oral squamous cell carcinoma (OSCC) tissues are rich in circRNAs and the results showed that hsa_circ_0008309 may be a potential biomarker for the OSCC . More importantly, circRNAs are considered as microRNA (miRNA) sponges and can influence the activity of some proteins .…”

Section: Introductionmentioning

confidence: 99%

“…15 Another study revealed that oral squamous cell carcinoma (OSCC) tissues are rich in circRNAs and the results showed that hsa_circ_0008309 may be a potential biomarker for the OSCC. 16 More importantly, circRNAs are considered as microRNA (miRNA) sponges and can influence the activity of some proteins. 17 Besides, downregulation of circTRIM33-12 acts as a sponge of mi-croRNA-191 to affect hepatocellular carcinoma (HCC) progression.…”

Section: Introductionmentioning

confidence: 99%

Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values

Ding

Yang

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Circular RNAs (circRNAs) are an abundant kind of endogenous RNAs that recently are found play a crucial role in the cancer occurrence and development. Nevertheless, little is known with regard to the diagnostic values of these circRNAs for GC. In this article of research, we investigated the role of hsa_circ_0067582 in clinical diagnosis of GC. Materials and Methods We used divergent primers, and the expression levels of hsa_circ_0067582 in 93 fresh GC tissues and paired adjacent normal tissues from surgical patients were detected using quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR). Then, a receiver operating characteristic (ROC) curve was established to assess the diagnostic significance of hsa_circ_0067582. The relationship between expression of hsa_circ_0067582 and clinicopathological factors of patients was made further explored. Results Hsa_circ_0067582 levels were significantly decreased in GC tissues contrasted with adjacent normal tissues (n = 93, P < .001). After that, we discovered that it was evidently downregulated in 81.7% (76/93) GC tissues. The area under the ROC curve (AUC) of hsa_circ_0067582 was up to 0.6937, the sensitivity was 66.67%, and the specificity was 61.29%. Moreover, the hsa_circ_0067582 levels were obviously associated with tumor diameter (P = .002) and carbohydrate antigen 19‐9 (CA19‐9, P = .01). Meanwhile, after operation, low‐level group of hsa_circ_0067582 of GC patients was associated with better prognosis. Conclusion Our data imply that hsa_circ_000067582 may be a potential biomarker for GC diagnosis and prognosis evaluation.

show abstract

Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma

Cited by 45 publications

References 22 publications

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values

Contact Info

Product

Resources

About