Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer

Chang, Feiyun; Li, Jiali; Sun, Quan; Wei, Shuqing; Song, Yongming

doi:10.1080/21655979.2022.2053810

Cited by 9 publications

(5 citation statements)

References 60 publications

(63 reference statements)

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“…We revealed that hsa_circ_0086735 contributed to the resistance of tamoxifen. miR-1296-5p inhibitor has been discovered to restore the decreased cisplatin resistance in cisplatin-resistant non-small cell lung cancer cells (Chang et al, 2022). In this study, miR-1296-5p inhibitor restored the tamoxifen resistance in ZR-75-1 Tam1 cells.…”

Section: Discussionmentioning

confidence: 69%

“…MiR-1296-5p has been reported to decrease ERBB2-positive breast cancer and exerts a tumor-suppressive function in breast cancer (Chen et al, 2017). The other known circRNAs that can target miR-1296-5p include hsa_circs_0000517, hsa_circ_0017639, and circ_ 0048764 (Zang et al, 2020;Chang et al, 2022). STAT1 was verified to accelerate breast cancer via deregulating homeostasis of the tumor microenvironment (Zellmer et al, 2017;Hou et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Identification of circRNA-miRNA-mRNA network in luminal breast cancers by integrated analysis of microarray datasets

Huang¹,

Qian²,

Chu³

et al. 2023

Front. Mol. Biosci.

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Introduction: Circular RNAs (circRNAs) regulatory network is important in human cancer. We, therefore, mapped the regulatory networks driven by circRNA in luminal-subtype breast cancer.Methods: Breast cancer-related microarray datasets from GEO database were analyzed for the differentially expressed circRNAs, miRNAs, and mRNAs. The potential downstream RNAs were collected using Circular RNA Interactome or Targetscan database. Protein-protein interaction (PPI) analysis was performed for the filtered genes to identify hub genes. The functions were annotated by the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. CircRNA-miRNA-mRNA networks were mapped using Cytoscape software. Hsa_circ_0086735-miR-1296-5p-STAT1 axis was used for verification. The expression levels of hsa_circ_0086735, miR-1296-5p, and STAT1 mRNA were confirmed by qRT-PCR in luminal-subtype tissues and cell lines. The interactions among them were verified by Luciferase reporter assay and RNA pull-down assay. Cell proliferation and apoptosis were assayed. Overall and distant metastasis-free survival was analyzed.Results: A total of 70 genes were finally targeted and enriched in multi-process and multi-pathway. Networks containing 96 circRNA-miRNA-mRNA axes were constructed. Hsa_circ_0086735 and STAT1 mRNA was upregulated in luminal breast cancer, while miR-1296-5p was downregulated. Hsa_circ_0086735-miR-1296-5p-STAT1 axis promotes breast cancer progression and contributes to tamoxifen resistance. High hsa_circ_0086735 was associated with poor overall and distant metastasis-free survival.Discussion: This study identified the hsa_circ_0086735-miR-1296-5p-STAT1 as an important regulatory axis in luminal-subtype breast cancer, aiding to determine potential therapeutic targets.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Identification of circRNA-miRNA-mRNA network in luminal breast cancers by integrated analysis of microarray datasets

Huang¹,

Qian²,

Chu³

et al. 2023

Front. Mol. Biosci.

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“…It has been documented that circRNAs control cellular processes through several mechanisms which include modulating transcription ( 23 ), serving as sponge for miRNAs ( 134 ), acting as a platform or sponge for proteins ( 65 ), regulating splicing at the same locus ( 22 ), forming functional circRNA-protein complexes ( 65 ), directly binding to mRNAs to regulate their expression, outcompeting linear mRNAs for protein binding and encoding peptides ( 5 , 146 ). However, a vast majority of reports in drug resistance-associated circRNAs have focused on their function as miRNA sponge ( 107 , 119 ). Further investigations are needed to elucidate involvement of other molecular mechanisms of circRNAs in NSCLC drug resistance.…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

“…found that circ_0017639 silencing inhibited tumor growth and enhanced CDDP sensitivity in vivo . Meanwhile, circ_0017639 also promoted apoptosis and suppressed proliferation, invasion, and migration of CDDP-resistant NSCLC cells via miR-1296-5p/SIX1 axis in vitro ( 107 ). These results indicate that circRNAs are supposed to be the functional biomarkers and novel therapeutic targets for NSCLC.…”

Section: Specific Drug Resistance Associated With Circrnas In Nsclcmentioning

confidence: 99%

The emerging role of circular RNAs in drug resistance of non-small cell lung cancer

et al. 2022

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Due to the characteristics of aggressiveness and high risk of postoperative recurrence, non-small cell lung cancer (NSCLC) is a serious hazard to human health, accounting for 85% of all lung cancer cases. Drug therapies, including chemotherapy, targeted therapy and immunotherapy, are effective treatments for NSCLC in clinics. However, most patients ultimately develop drug resistance, which is also the leading cause of treatment failure in cancer. To date, the mechanisms of drug resistance have yet to be fully elucidated, thus original strategies are developed to overcome this issue. Emerging studies have illustrated that circular RNAs (circRNAs) participate in the generation of therapeutic resistance in NSCLC. CircRNAs mediate the modulations of immune cells, cytokines, autophagy, ferroptosis and metabolism in the tumor microenvironment (TME), which play essential roles in the generation of drug resistance of NSCLC. More importantly, circRNAs function as miRNAs sponges to affect specific signaling pathways, directly leading to the generation of drug resistance. Consequently, this review highlights the mechanisms underlying the relationship between circRNAs and drug resistance in NSCLC. Additionally, several therapeutic drugs associated with circRNAs are summarized, aiming to provide references for circRNAs serving as potential therapeutic targets in overcoming drug resistance in NSCLC.

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“…circRNA-SFMBT2 (hsa_circ_0017639) is a circular RNA transcript originating from the host protein-coding gene SFMBT2. Recently, circRNA-SFMBT2 was reported to function as a tumor promoter in gastric cancer [ 24 ], non-small lung cancer [ 25 , 26 ], and acute myeloid leukemia [ 27 ]. However, little is known about its regulatory role in other tumor types.…”

Section: Introductionmentioning

confidence: 99%

circRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells

Li,

Han

et al. 2023

Cell Death Dis

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Dysregulated ERα signaling is responsible for endocrine resistance and eventual relapse in patients with estrogen receptor-positive (ER+) breast cancer. Thus, identifying novel ERα regulators is necessary to fully understand the mechanisms of endocrine resistance. Here, we identified circRNA-SFMBT2 to be highly expressed in ER+ breast cancer cells in comparison to ER− cells and found that high circRNA-SFMBT2 levels were related to larger tumor size and poor prognosis in patients with ER+ breast cancer. In vitro and in vivo experiments confirmed that the circRNA-SFMBT2 level was positively correlated with the ERα protein level, implying a regulatory role for circRNA-SFMBT2 in ERα signaling. Moreover, we found that circRNA-SFMBT2 biogenesis could be facilitated via RNA-binding protein quaking (QKI), and biologically elevated circRNA-SFMBT2 expression promoted cell growth and tamoxifen resistance in ER+ breast cancer. Mechanistically, circRNA-SFMBT2 exhibits a specific tertiary structure that endows it with a high binding affinity for ERα and allows it to interact with the AF2 and DBD domains of ERα, enforcing recruitment of RNF181 to the AF1 domain of ERα. Furthermore, the circRNA-SFMBT2/RNF181 axis differentially regulated K48-linked and K63-linked ubiquitination of ERα to enhance ERα stability, resulting in increased expression of ERα target genes and tumor progression. In summary, circRNA-SFMBT2 is an important regulator of ERα signaling, and antagonizing circRNA-SFMBT2 expression may constitute a potential therapeutic strategy for breast cancer.

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Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer

Cited by 9 publications

References 60 publications

Identification of circRNA-miRNA-mRNA network in luminal breast cancers by integrated analysis of microarray datasets

Identification of circRNA-miRNA-mRNA network in luminal breast cancers by integrated analysis of microarray datasets

The emerging role of circular RNAs in drug resistance of non-small cell lung cancer

circRNA-SFMBT2 orchestrates ERα activation to drive tamoxifen resistance in breast cancer cells

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