Hsa_circ_0058129 regulates papillary thyroid cancer development via miR‐873‐5p/follistatin‐like 1 axis

Tan, Xiangrong; Zhao, Jiazheng; Lou, Jianlin; Zheng, Wen; Wang, Peng

doi:10.1002/jcla.24401

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…Moreover, circFN1 interacts with miR-370-3p to modify the expression of LMO4, which has the potential to function as an oncogene or a transcriptional regulator ( 35 ). Additionally, circFN1 promotes the progression of PTC by sponging miR-873-5p while restraining the malignancy of PTC cells by binding to FSTL1 ( 84 ).…”

Section: Circrnas In Ptcmentioning

confidence: 99%

The emerging role and clinical significance of circRNAs in papillary thyroid cancer

Ma,

Xu,

Zhang

et al. 2024

Front. Endocrinol.

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Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and its global incidence has been gradually increasing. For advanced PTC, the mortality rates are also increasing yearly. Despite advancements in diagnosis and treatment, some advanced PTC exhibit aggressive behaviors, leading to a poor prognosis. CircRNAs are a class of non-coding RNAs characterized by a covalently closed loop structure. Their stability and abundance have positioned them as promising diagnostic and prognostic biomarkers. Numerous studies have identified dysregulated circRNAs in PTC tissues and cell lines, suggesting their involvement in PTC initiation and progression. In this review, we provide an overview of circRNAs and systematically discuss their role in PTC. CircRNAs affect cancer progression by regulating the Wnt/β-catenin, PI3K/AKT, MAPK pathways, and others. Furthermore, circRNAs have been implicated in PTC metastasis and chemoresistance. We highlight their potential value as diagnostic markers, therapeutic targets, and prognostic indicators. In conclusion, circRNAs play a critical role in PTC, and dysregulated circRNAs influence multiple signaling pathways and cellular processes involved in tumorigenesis and metastasis. It represents a promising avenue for advancing the diagnosis, management, and treatment of PTC.

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Section: Circrnas In Ptcmentioning

confidence: 99%

The emerging role and clinical significance of circRNAs in papillary thyroid cancer

Ma,

Xu,

Zhang

et al. 2024

Front. Endocrinol.

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“…By designing primers flanking the back-splice site, circular RNAs can be quantified specifically. Examples of circular RNAs found to be dysregulated in thyroid cancer cells include circITGA7, circRAPGEF5, circ_0058129, and circ_0005273 [ 74 , 81 , 83 ]. However, further research is required to gather robust data and propose circular RNAs as clinical biomarkers.…”

Section: Emerging Molecular Markers For Thyroid Cancer: Opportunities...mentioning

confidence: 99%

Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space

Cabané,

Correa,

Bode

et al. 2024

IJMS

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Thyroid cancer diagnosis primarily relies on imaging techniques and cytological analyses. In cases where the diagnosis is uncertain, the quantification of molecular markers has been incorporated after cytological examination. This approach helps physicians to make surgical decisions, estimate cancer aggressiveness, and monitor the response to treatments. Despite the availability of commercial molecular tests, their widespread use has been hindered in our experience due to cost constraints and variability between them. Thus, numerous groups are currently evaluating new molecular markers that ultimately will lead to improved diagnostic certainty, as well as better classification of prognosis and recurrence. In this review, we start reviewing the current preoperative testing methodologies, followed by a comprehensive review of emerging molecular markers. We focus on micro RNAs, long non-coding RNAs, and mitochondrial (mt) signatures, including mtDNA genes and circulating cell-free mtDNA. We envision that a robust set of molecular markers will complement the national and international clinical guides for proper assessment of the disease.

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“…Moreover, miR-873-5p repressed PTC cell malignancy by binding to FSTL1. Circ_0058129 targeted miR-873-5p to regulate FSTL1 [133]. Circ_0005273 was overexpressed in PTC cell lines (KTC-1, IHH-4, BCPAP, TPC-1).…”

Section: Tumorigenesis-related Circrnasmentioning

confidence: 99%

A Review and In Silico Analysis of Tissue and Exosomal Circular RNAs: Opportunities and Challenges in Thyroid Cancer

Toraih

Hussein

Fawzy

et al. 2022

Cancers

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Thyroid cancer (TC) is the most common endocrine tumor. The genetic and epigenetic molecular alterations of TC have become more evident in recent years. However, a deeper understanding of the roles these molecular changes play in TC tumorigenesis and progression is essential in developing a successful treatment strategy and improving patients’ prognoses. Circular RNAs (circRNAs), a family of non-coding RNAs, have been implicated in several aspects of carcinogenesis in multiple cancers, including TC. In the current review, we aimed to explore the clinical potential of circRNAs as putative diagnostic, prognostic, and therapeutic targets in TC. The current analyses, including genome-wide circRNA screening and functional enrichment for all deregulated circRNA expression signatures, show that circRNAs display atypical contributions, such as sponging for microRNAs, regulating transcription and translation processes, and decoying for proteins. Given their exceptional clinical advantages, such as higher stability, wider abundance, and occurrence in several body fluids, circRNAs are promising prognostic and theranostic biomarkers for TC.

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Hsa_circ_0058129 regulates papillary thyroid cancer development via miR‐873‐5p/follistatin‐like 1 axis

Cited by 6 publications

References 43 publications

The emerging role and clinical significance of circRNAs in papillary thyroid cancer

The emerging role and clinical significance of circRNAs in papillary thyroid cancer

Biomarkers in Thyroid Cancer: Emerging Opportunities from Non-Coding RNAs and Mitochondrial Space

A Review and In Silico Analysis of Tissue and Exosomal Circular RNAs: Opportunities and Challenges in Thyroid Cancer

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