Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma

Yuan, Fanen; Sun, Qian; Ye, Liguo; Xu, Yang; Zhou, Xu; Deng, Gang; Zhang, Shenqi; Liu, Baohui

doi:10.1111/cns.13821

Cited by 19 publications

(14 citation statements)

References 30 publications

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“…As a common upstream regulatory gene of mRNA, miRNA has attracted our attention. Moreover, a quite few miRNA species have been suggested to be biomarkers for glioma 32–34 . For instance, miR‐339/342 can be targeted by FOXD1‐AS1 to regulate glioma biological processes 34 .…”

Section: Discussionmentioning

confidence: 99%

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LncRNA LINC01018/miR‐942‐5p/KNG1 axis regulates the malignant development of glioma in vitro and in vivo

Wang

Zhao

et al. 2022

CNS Neurosci Ther

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Aims Since the inhibitory effect of KNG1 on glioma has been proved, this study further explores the regulation of the lncRNA/miRNA axis on KNG1 in glioma. Methods The miRNAs that target KNG1 and the lncRNA that targets miR‐942‐5p were predicted by bioinformatics analysis and verified by experiments. The correlations between miR‐942‐5p and the survival of patients and between KNG1 and miR‐942‐5p were analyzed. After transfection, cell migration, invasion, proliferation, and cell cycle were detected through wound healing, Transwell, colony formation, and flow cytometry assays. A mouse subcutaneous xenotransplanted tumor model was established. The expressions of miR‐942‐5p, KNG1, LINC01018, and related genes were evaluated by quantitative real‐time reverse transcription polymerase chain reaction (RT‐qPCR), Western blot, or immunohistochemistry. Results MiR‐942‐5p targeted KNG1, and LINC01018 sponged miR‐942‐5p. The high survival rate of patients was related to low miR‐942‐5p level. MiR‐942‐5p was highly expressed, whereas KNG1 was lowly expressed in glioma. MiR‐942‐5p was negatively correlated with KNG1. Silent LINC01018 or KNG1 and miR‐942‐5p mimic enhanced the migration, invasion, and proliferation of glioma cells, and regulated the expressions of metastasis‐related and proliferation‐related genes. LINC01018 knockdown and miR‐942‐5p mimic promoted glioma tumor growth in mice. The levels of miR‐942‐5p and KNG1 were decreased by LINC01018 knockdown, and LINC01018 expression was suppressed by miR‐942‐5p mimic. MiR‐942‐5p inhibitor, KNG1, and LINC01018 had the opposite effect to miR‐942‐5p mimic. Conclusion LINC01018/miR‐942‐5p/KNG1 pathway regulates the development of glioma cells in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, a quite few miRNA species have been suggested to be biomarkers for glioma. [32][33][34] For instance, miR-339/342 can be targeted by FOXD1-AS1 to regulate glioma biological processes. 34 and Kaposi's Sarcoma.…”

Section: Discussionmentioning

confidence: 99%

LncRNA LINC01018/miR‐942‐5p/KNG1 axis regulates the malignant development of glioma in vitro and in vivo

Wang

Zhao

et al. 2022

CNS Neurosci Ther

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“…14 Yuan et al found that hsa_circ_0072309 promotes autophagy among glioblastoma cells and increases their sensitivity to temozolomide through a P53-dependent mechanism. 15 Furthermore, circRNAs have been used to help diagnose disease based on liquid biopsies of tumors. 16 Existing knowledge of the functions of circRNAs in disease has primarily focused on diagnosis and therapy.…”

Section: Circrna S and D Is E A S Ementioning

confidence: 99%

CircRNA and ferroptosis in human disease: Insights for new treatments

Liu,

Zhou,

Cao

2023

Anim Models and Exp Med

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Circular RNA (circRNA), classified as a type of non‐coding RNA, has gained significant attention in the field of biology due to its distinctive ring structure and functional properties. Recent research has provided evidence that specific circRNAs have the ability to modulate disease progression through diverse mechanisms, one of which is by regulating cellular ferroptosis. Ferroptosis is a form of regulated cell death that is driven by iron dependency and lipid peroxidation, and extensive investigations have revealed a relationship between ferroptosis and disease development. In addition to evidence that both circRNAs and ferroptosis exert critical roles in disease progression, circRNAs have also been shown to actively mediate the process of ferroptosis. The relationship between circRNAs and ferroptosis therefore influences disease progression and offers novel targets for disease treatment. By directly or indirectly modulating the expression of circRNAs that regulate the expression of ferroptosis‐related proteins, it may be possible to impact disease progression by promoting or inhibiting ferroptosis. Current research indicates such approaches may hold significant value in a wide variety of common diseases across physiological systems. This review comprehensively summarizes the findings of recent studies investigating the roles of circRNAs in the regulation of ferroptosis in various diseases.

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“…or autophagy inhibitor. 104 It would be highly beneficial if circRNAs were identified as critical players in the molecular mechanism of glioma so that targeted treatments can be developed.…”

Section: Circrna and G LI Omamentioning

confidence: 99%

The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors

Zhang,

Wang

et al. 2023

CNS Neurosci Ther

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BackgroundCentral nervous system (CNS) tumors originate from the spinal cord or brain. The study showed that even with aggressive treatment, malignant CNS tumors have high mortality rates. However, CNS tumor risk factors and molecular mechanisms have not been verified. Due to the reasons mentioned above, diagnosis and treatment of CNS tumors in clinical practice are currently fraught with difficulties. Circular RNAs (circRNAs), single‐stranded ncRNAs with covalently closed continuous structures, are essential to CNS tumor development. Growing evidence has proved the numeral critical biological functions of circRNAs for disease progression: sponging to miRNAs, regulating gene transcription and splicing, interacting with proteins, encoding proteins/peptides, and expressing in exosomes.AimsThis review aims to summarize current progress regarding the molecular mechanism of circRNA in CNS tumors and to explore the possibilities of clinical application based on circRNA in CNS tumors.MethodsWe have summarized studies of circRNA in CNS tumors in Pubmed.ResultsThis review summarized their connection with CNS tumors and their functions, biogenesis, and biological properties. Furthermore, we introduced current advances in clinical RNA‐related technologies. Then we discussed the diagnostic and therapeutic potential (especially for immunotherapy, chemotherapy, and radiotherapy) of circRNA in CNS tumors in the context of the recent advanced research and application of RNA in clinics.ConclusionsCircRNA are increasingly proven to participate in decveloping CNS tumors. An in‐depth study of the causal mechanisms of circRNAs in CNS tomor progression will ultimately advance their implementation in the clinic and developing new strategies for preventing and treating CNS tumors.

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Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma

Cited by 19 publications

References 30 publications

LncRNA LINC01018/miR‐942‐5p/KNG1 axis regulates the malignant development of glioma in vitro and in vivo

LncRNA LINC01018/miR‐942‐5p/KNG1 axis regulates the malignant development of glioma in vitro and in vivo

CircRNA and ferroptosis in human disease: Insights for new treatments

The regulatory role and clinical application prospects of circRNA in the occurrence and development of CNS tumors

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