Hsa_circ_0129047 regulates the <scp>miR</scp>‐375/<scp>ACVRL1</scp> axis to attenuate the progression of lung adenocarcinoma

Fan, Jinxiu; Xia, Xiaofan; Fan, Zhongjie

doi:10.1002/jcla.24591

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…ACVRL1 has been shown to primarily participate in the formation of blood vessels, and mutations of this gene can cause various hemorrhagic disorders[ 21 - 23 ]. Furthermore, the heightened expression of ACVRL1 through transcriptional activity exhibits anti-tumor properties in lung adenocarcinoma cells[ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers: A case report and review of literature

Tang,

Zhang,

Wang

et al. 2024

World J Gastrointest Surg

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BACKGROUND Genetic factors of chronic intestinal ulcers are increasingly garnering attention. We present a case of chronic intestinal ulcers and bleeding associated with mutations of the activin A receptor type II-like 1 (ACVRL1 ) and phospholipase A2 group IVA (PLA2G4A ) genes and review the available relevant literature. CASE SUMMARY A 20-year-old man was admitted to our center with a 6-year history of recurrent abdominal pain, diarrhea, and dark stools. At the onset 6 years ago, the patient had received treatment at a local hospital for abdominal pain persisting for 7 d, under the diagnosis of diffuse peritonitis, acute gangrenous appendicitis with perforation, adhesive intestinal obstruction, and pelvic abscess. The surgical treatment included exploratory laparotomy, appendectomy, intestinal adhesiolysis, and pelvic abscess removal. The patient’s condition improved and he was discharged. However, the recurrent episodes of abdominal pain and passage of black stools started again one year after discharge. On the basis of these features and results of subsequent colonoscopy, the clinical diagnosis was established as inflammatory bowel disease (IBD). Accordingly, aminosalicylic acid, immunotherapy, and related symptomatic treatment were administered, but the symptoms of the patient did not improve significantly. Further investigations revealed mutations in the ACVRL1 and PLA2G4A genes. ACVRL1 and PLA2G4A are involved in angiogenesis and coagulation, respectively. This suggests that the chronic intestinal ulcers and bleeding in this case may be linked to mutations in the ACVRL1 and PLA2G4A genes. Oral Kangfuxin liquid was administered to promote healing of the intestinal mucosa and effectively manage clinical symptoms. CONCLUSION Mutations in the ACVRL1 and PLA2G4A genes may be one of the causes of chronic intestinal ulcers and bleeding in IBD. Orally administered Kangfuxin liquid may have therapeutic potential.

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Section: Discussionmentioning

confidence: 99%

Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers: A case report and review of literature

Tang,

Zhang,

Wang

et al. 2024

World J Gastrointest Surg

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“…In the present study, we found that circ_0129047 is downregulated in HCC tissues and cells ( Figure 1 ). According to previous studies, circ_0129047 was reported to play an antitumorigenic role in lung adenocarcinoma [ 11 , 24 ]. However, the role of circ_0129047 in HCC remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, cytoplasmic circRNAs compete for miRNA binding and modulate mRNA turnover [ 25 ]. circ_0129047 suppresses the progression of lung adenocarcinoma by binding to miR-375 [ 24 ] or miR-1206 [ 11 ]. In contrast to previous studies on lung adenocarcinoma, we found that circ_0129047 recognizes miR-492 and downregulates its expression in HCC cells ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular Carcinoma Progression by Sponging miR-492

Feng,

2023

Disease Markers

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Compelling evidence indicates the regulatory role of circular RNAs in cancers, including hepatocellular carcinoma (HCC). Our study aimed to elucidate the regulatory function of circ_0129047 in HCC progression. A reverse transcription-quantitative polymeric chain reaction was conducted to detect the expression of circ_0129047, lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1), and miR-492 in HCC tissues and cells. The characteristics of circ_0129047 were determined by evaluating the nuclear and cytoplasmic fractions and by RNase R digestion assays. The cell counting kit-8 assay, scratch wound, and transwell invasion assays were used to examine the effects of circ_0129047 overexpression, miR-492 mimic, and LYVE1 overexpression on the proliferation, migration, and invasion abilities of HCC cells in vitro. A mouse xenograft model was also established. The relationship between miR-492 and circ_0129047 or LYVE1 was clarified using luciferase reporter and Argonaute-2 RNA immunoprecipitation assays. We found that circ_0129047 and LYVE1 were poorly expressed in HCC tissues and cells, whereas miR-492 was upregulated. Overexpression of circ_0129047 inhibits HCC cell proliferation, migration, and invasion and delays in vivo tumor growth. Furthermore, circ_0129047 sponged miR-492, and 3′UTR LYVE1 was a direct target of miR-492. Additionally, LYVE1 overexpression reduced the oncogenic activity of the miR-492 mimic, whereas the miR-492 mimic abolished the antimigratory, antiproliferative, and anti-invasive effects of circ_0129047 overexpression in HCC cells. These data suggest that circ_0129047 exerts a tumor-suppressive role in HCC by sponging miR-492 away from LYVE1 and that the circ_0129047/miR-492/LYVE1 axis may be a promising target for HCC treatment.

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“…It has been widely acknowledged that miRNAs are involved in circRNA's biological effects [28][29][30]. Intriguingly, CSCD database [21] analysis revealed that hsa_circ_0037858 possessed potential microRNA response elements.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis reveals the involvement of hsa_circ_0037858/miR-5000-3p/FMR1 axis in malignant metastasis of clear cell renal cell carcinoma

Nianyong,

2023

Aging

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Clear cell renal cell carcinoma (ccRCC) is a heterogenous tumor with high metastatic potential. Circular RNAs (circRNAs) play key roles in cancer initiation and progression. However, the knowledge of circRNA in ccRCC metastasis is still inadequate. In this study, a series of in silico analyses and experimental validation were employed. The differentially expressed circRNAs (DECs) between ccRCC and normal or metastatic ccRCC tissues were screened out using GEO2R. Hsa_circ_0037858 was identified as the most potential circRNA related to ccRCC metastasis, which was significantly downregulated in ccRCC compared with normal and was also markedly decreased in metastatic ccRCC compared with primary ccRCC. The structural pattern of hsa_circ_0037858 presented several microRNA response elements and four binding miRNAs of hsa_circ_0037858, consisting of miR-3064-5p, miR-6504-5p, miR-345-5p and miR-5000-3p, were predicted using CSCD and starBase. Among them, miR-5000-3p with high expression and statistical diagnostic value was considered as the most potential binding miRNA of hsa_circ_0037858. Then, protein-protein interaction analysis revealed a close linkage among the target genes of miR-5000-3p and the top 20 hub genes among them were identified. Based on node degree, MYC , RHOA , NCL , FMR1 and AGO1 were ranked as the top 5 hub genes. FMR1 was identified as the most potential downstream gene of hsa_circ_0037858/miR-5000-3p axis according to expression, prognosis and correlation analysis. Moreover, hsa_circ_0037858 suppressed in vitro metastasis and enhanced FMR1 expression in ccRCC, which could be markedly reversed by introduction of miR-5000-3p overexpression. Collectively, we elucidated a potential hsa_circ_0037858/miR-5000-3p/ FMR1 axis involved in ccRCC metastasis.

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Hsa_circ_0129047 regulates the miR‐375/ACVRL1 axis to attenuate the progression of lung adenocarcinoma

Cited by 7 publications

References 28 publications

Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers: A case report and review of literature

Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers: A case report and review of literature

hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular Carcinoma Progression by Sponging miR-492

Comprehensive analysis reveals the involvement of hsa_circ_0037858/miR-5000-3p/FMR1 axis in malignant metastasis of clear cell renal cell carcinoma

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