HSC-derived exosomal miR-199a-5p promotes HSC activation and hepatocyte EMT via targeting SIRT1 in hepatic fibrosis

Lu, Hongjian; Zhang, Ronghua; Zhang, Shukun; Li, Yufeng; Liu, Yankun; Xiong, Yanan; Yu, Xiaohan; Lan, Tao; Li, Xin; Wang, Meimei; Liu, Zhiyong; Zhang, Guangling; Li, Jingwu; Chen, Shuang

doi:10.1016/j.intimp.2023.111002

International Immunopharmacology

2023

DOI: 10.1016/j.intimp.2023.111002

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HSC-derived exosomal miR-199a-5p promotes HSC activation and hepatocyte EMT via targeting SIRT1 in hepatic fibrosis

Hongjian Lu,

Ronghua Zhang,

Shukun Zhang

et al.

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2024

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Cited by 3 publications

References 37 publications

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Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review

Mahmoudi,

Meidany,

Almahmeed

et al. 2024

Curr Stem Cell Rep

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Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review

Mahmoudi,

Meidany,

Almahmeed

et al. 2024

Curr Stem Cell Rep

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Extracellular Vesicles and Micro-RNAs in Liver Disease

Washington,

Kostallari

2024

Semin Liver Dis

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Progression of liver disease is dependent on intercellular signaling, including those mediated by extracellular vesicles (EVs). Within these EVs, microRNAs (miRNAs) are packaged to selectively silence gene expression in recipient cells for upregulating or downregulating a specific pathway. Injured hepatocytes secrete EV-associated miRNAs which can be taken up by liver sinusoidal endothelial cells (LSECs), immune cells, hepatic stellate cells (HSCs), and other cell types. In addition, these recipient cells will secrete their own EV-associated miRNAs to propagate a response throughout the tissue and the circulation. In this review, we comment on the implications of EV-miRNAs in the progression of alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatohepatitis (MASH), viral and parasitic infections, liver fibrosis, and liver malignancies. We summarize how circulating miRNAs can be used as biomarkers and the potential of utilizing EVs and miRNAs as therapeutic methods to treat liver disease.

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Extracellular Vesicles in Viral Liver Diseases

Kouroumalis,

Tsomidis,

Voumvouraki

2024

Viruses

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Extracellular vesicles (EVs) are bilayer vesicles released by cells in the microenvironment of the liver including parenchymal and non-parenchymal cells. They are the third important mechanism in the communications between cells, besides the secretion of cytokines and chemokines and the direct cell-to-cell contact. The aim of this review is to discuss the important role of EVs in viral liver disease, as there is increasing evidence that the transportation of viral proteins, all types of RNA, and viral particles including complete virions is implicated in the pathogenesis of both viral cirrhosis and viral-related hepatocellular carcinoma. The biogenesis of EVs is discussed and their role in the pathogenesis of viral liver diseases is presented. Their use as diagnostic and prognostic biomarkers is also analyzed. Most importantly, the significance of possible novel treatment strategies for liver fibrosis and hepatocellular carcinoma is presented, although available data are based on experimental evidence and clinical trials have not been reported.

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HSC-derived exosomal miR-199a-5p promotes HSC activation and hepatocyte EMT via targeting SIRT1 in hepatic fibrosis

Cited by 3 publications

References 37 publications

Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review

Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review

Extracellular Vesicles and Micro-RNAs in Liver Disease

Extracellular Vesicles in Viral Liver Diseases

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