Hsp-27 levels and thrombus burden relate to clinical outcomes in patients with ST-segment elevation myocardial infarction

Tian, Mi; Zhu, Lingmin; Lin, Hongyang; Lin, Qi‐Chang; Huang, Ping; Yu, Xiang; Jing, Yanyan

doi:10.18632/oncotarget.17852

Cited by 7 publications

(8 citation statements)

References 47 publications

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“…Preinfarction angina, heat shock protein 27, platelet indices, and monocyte to HDL-C ratio were independent predictors of LTB. 19 –21 Similar to previous studies, HDL-C levels were significantly lower in patients with high thrombus burden in our study. 22 It is also noteworthy that LTB is more frequent in patients with low eGFR on admission and high serum creatinine in our study.…”

Section: Discussionsupporting

confidence: 90%

Can Thrombus Burden Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?

et al. 2019

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The incidence of contrast-induced nephropathy (CIN) increases in the range from patients with unstable angina to ST-segment elevation myocardial infarction (STEMI). Platelet activation has been associated with pathophysiology of nephropathy and thrombus burden in the infarct-related arteries. We investigated the impact of thrombus burden on CIN in patients with STEMI. We enrolled 883 patients with STEMI who received primary percutaneous coronary intervention. Patients were divided into groups according to thrombus burden and CIN development. Thrombus burden was scored based on thrombolysis in myocardial infarction thrombus grades (TGs). Thrombus grade 4 was defined as large thrombus burden (LTB), while thrombus burden <TG 4 was defined as small thrombus burden. A total of 126 (14.2%) patients with STEMI had CIN, while 313 (35.4%) patients had LTB. Compared to CIN (−) patients, CIN (+) patients were older, had lower hemoglobin levels, lower ejection fraction, and higher contrast media volume administration. Multivariate logistic regression analysis demonstrated that LTB, age, hypertension, and admission glomerular filtration rate were independent predictors of CIN ( P = .016, P < .001, P = .028, P < .001, respectively). Thrombus burden, which is measurable during angiography, may be helpful in the determination of CIN risk in patients with STEMI.

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Section: Discussionsupporting

confidence: 90%

Can Thrombus Burden Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?

et al. 2019

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“…Serum concentrations of HSPs are under investigation as potential biomarkers in several fields 11–15,36,37 . Based on previous and presented results, recent trauma in patients´ medical history needs to be carefully considered as confounder of HSP serum concentrations.…”

Section: Discussionmentioning

confidence: 99%

Systemic release of heat-shock protein 27 and 70 following severe trauma

Haider

Simader

Gluck

et al. 2019

Sci Rep

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Trauma represents a major cause of morbidity and mortality worldwide. The endogenous inflammatory response to trauma remains not fully elucidated. Pro-inflammation in the early phase is followed by immunosuppression leading to infections, multi-organ failure and mortality. Heat-shock proteins (HSPs) act as intracellular chaperons but exert also extracellular functions. However, their role in acute trauma remains unknown. The aim of this study was to evaluate serum concentrations of HSP 27 and HSP 70 in severely injured patients. We included severely injured patients with an injury severity score of at least 16 and measured serum concentration of both markers at admission and on day two. We found significantly increased serum concentrations of both HSP 27 and HSP 70 in severely injured patients. Concomitant thoracic trauma lead to a further increase of both HSPs. Also, elevated concentrations of HSP 27 and HSP 70 were associated with poor outcome in these patients. Standard laboratory parameters did not correlate with neither HSP 27, nor with HSP 70. Our findings demonstrate involvement of systemic release of HSP 27 and HSP 70 after severe trauma and their potential as biomarker in polytraumatized patients.

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“…HSPs are involved in apoptosis inhibition, cytoprotection, and immunomodulation [39]- [41]. Moreover, HSP27 may play a major role in platelet aggregation by modifying actin polymerization [10], [42]. Tian et al [10] found an association between a high thrombus burden and elevated HSP27 levels in patients with ST elevation myocardial infarctions.…”

Section: Hsp27mentioning

confidence: 99%

“…Moreover, HSP27 may play a major role in platelet aggregation by modifying actin polymerization [10], [42]. Tian et al [10] found an association between a high thrombus burden and elevated HSP27 levels in patients with ST elevation myocardial infarctions. In addition, recently, HSP27 was identified as prognostic marker in inflammatory diseases, such as COPD and trauma-related ARDS [24], [25], [43], [44].…”

Section: Hsp27mentioning

confidence: 99%

“…Indeed, cytokine overproduction is a characteristic feature of ARDS; consequently, several studies have suggested that a cytokine storm may be the main pathogenic factor in COVID-19-related ARDS. [9], [10]. Additionally, the overproduction of inflammatory cytokines is involved in the subsequent development of microthrombosis, disseminated intravascular coagulation, and multiorgan-failure.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome in Patients with COVID-19

Wendt¹,

Lingitz²,

Laggner³

et al. 2021

Preprint

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Although, severe acute respiratory syndrome coronavirus – 2 (SARS-CoV 2) represents one of the biggest challenges in the world today, the exact immunopathogenic mechanism that leads to severe or critical Coronavirus Disease 2019 (COVID-19) has remained incompletely understood. Several studies have indicated that high systemic plasma levels of inflammatory cytokines result in the so-called “cytokine storm”, with subsequent development of microthrombosis, disseminated intravascular coagulation, and multiorgan-failure. Therefore, we reasoned that elevated inflammatory cytokine might act as prognostic factors. Here, we analyzed 245 serum samples of patients with COVID-19, collected at hospital admission. We assessed the levels of heat shock protein 27 (HSP27), soluble suppressor of tumorigenicity- 2 (sST2), caspase cleaved cytokeratin 18 (cCK18), 20S proteasome, and tumor necrosis factor receptor 1 (TNFR-1) and explored their associations with overall-, 30-, 60-, 90-day- and in-hospital mortality. Moreover, we investigated their association with the risk of ventilation. We demonstrated that increased serum sST2 was uni- and multivariably associated with all endpoints. However, we also identified 20S proteasome as independent prognostic factor for in-hospital mortality. Furthermore, elevated HSP27, sST2, and 20S proteasome levels at hospital admission were univariably associated with higher risk of invasive ventilation. These findings could help to identify high-risk patients early in the course of COVID-19.

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Hsp-27 levels and thrombus burden relate to clinical outcomes in patients with ST-segment elevation myocardial infarction

Cited by 7 publications

References 47 publications

Can Thrombus Burden Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?

Can Thrombus Burden Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?

Systemic release of heat-shock protein 27 and 70 following severe trauma

Clinical Relevance of Elevated Soluble ST2, HSP27 and 20S Proteasome in Patients with COVID-19

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