HSP60 Predicts Survival in Advanced Serous Ovarian Cancer

Abstract

Heat shock protein 60 may identify groups of advanced serous ovarian cancer with different prognosis and treatment response.

Proteomic identification of proteins differentially expressed following overexpression of hTERT (human telomerase reverse transcriptase) in cancer cells

“…Hsp70 is overexpressed in most of the cancer cells though its expression in cancer cells is typically a poor marker for prognosis [14]. Heat shock protein 60 (HSP60) plays a crucial role in malignant cell survival [15]. To confirm regulation of Hsp60 and Hsp70 by hTERT, we performed qRT-PCR (Fig 4A and 4B) and western blotting (Fig 4C & 4D) to check their expression in U2OS and HeLa cells carrying pBABE-Vector and pBABE-hTERT expression construct.…”

Synergism of Cytotoxicity Effects of Triptolide and Artesunate Combination Treatment in Pancreatic Cancer Cell Lines

“…Among the heat shock proteins, three chaperones, HSP20, HSP27 and HSP60 were reported as important target in anti-tumor therapy (Guo et al, 2008;Edwards et al, 2011;Hjerpe et al, 2013). We were interested to know how they keep their function in triptolide and artesunate combination.…”

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

“…As such, the chaperonin has become the subject of studies aiming at determining its precise role as etiologic-pathogenic factor and also aiming at inventing new diagnostic and therapeutic ways centered on it. Adrenal gland Adrenal Cushing's tumor [168] Bladder Transitional cell carcinoma; carcinosarcoma [169][170][171] Bone marrow, blood, lymph nodes Acute myeloid leukemia; Hodgkin's lymphoma [155,[172][173][174] Brain Astroglyoma; glioblastoma; meningioma [175][176][177][178][179] Breast Breast ductal carcinoma [180,181] Esophagus Oesophageal carcinoma [182,183] Large bowel Adenocarcinoma [23,169,[184][185][186][187] Liver Hepatocellular carcinoma [188] Lung Bronchial carcinoma [25,26,189,190] Ovary Serous ovarian cancer [191] Prostate Prostate carcinoma [24,[192][193][194] Stomach Gastric maltoma [195] Uterus Exocervical carcinoma [22,196] Adapted from [2]. ATP synthase [197] Dihydrofolatereductase [37,46] Hsp10 [37,41] Human Carbonicanhydrase II [37,198,…”