Hsp70 function and polymorphism, its implications for mollusk aquaculture: a review

Abstract

Hsp70 proteins are widely found through several species, and they are considered among the most conservative proteins in nature, in both their sequence and function. They play an important role in the response mechanism to several different kinds of stress such as temperature and pathogens among others. In some species, the variations in the sequence of the Hsp70 gene result in intra-specific differential expression, and therefore in differences in thermo-tolerance of individuals as well as other productive characteristics. The study of the potential impact of the Hsp70 gene polymorphisms represents a field of study that could greatly help the mollusk farming industry.

A chromosome‐level assembly of the black tiger shrimp (Penaeus monodon) genome facilitates the identification of growth‐associated genes

“…C-type lectin, a known immune-related gene in shrimp, was induced by probiotics and subsequently improved the growth and survival of L. vannamei (Chai et al, 2016). Hsp70 is one of the most conserved genes responding to various stresses such as temperature changes and pathogen invasion by helping the cells to recover from damaged proteins and in turn increasing the survival probability and life span (Valenzuela-Castillo et al, 2019). For example, the grass thrip,…”

The loss of seed mussels in longline aquaculture

“…Even though cells have their own protective and repair mechanisms to re-establish homeostasis (eg increased antioxidant activity and upregulation of chaperone proteins), under severe stress these mechanisms become overwhelmed and cannot mediate the accumulation of reactive oxygen species (ie oxidative stress), resulting in structural and functional damage of macromolecules including lipids, proteins, carbohydrates and DNA. [60][61][62] The accumulation of damaged macromolecules can have deleterious effects in the organism and eventually cause death.…”

“…is an emerging field of aquaculture research. 79,[84][85][86] Mass summermortality events have been noted for many cultured bivalves and are likely due to a combination of temperature stress 60 and thermally induced immunity depression that allow pathogens to take hold and resulting in significant mortalities in many cultured molluscs. 81,87,88 The increasing frequency of heatwave events worldwide suggests that many species, including mussels, are likely to face increased challenges in the future.…”

In situ experiment to evaluate biochemical responses in the freshwater mussel Diplodon chilensis under anthropogenic eutrophication conditions

“…In marine and freshwater bivalves, HSP-70 and HSP-90 are induced by exposure to metals (e.g. Valenzuela-Castillo et al, 2019;Radlowska and Pempkowiak, 2002). Particularly, in D. chilensis, experimental hypoxia and anoxia induce the expression of HSP-90 (Yusseppone et al, 2018).…”