1994
DOI: 10.1007/bf00171790
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Hsp70 genes are linked to the Xenopus major histocompatibility complex

Abstract: Some of the inducible forms of the heat shock protein 70 (Hsp70) gene family are encoded in the class III region of the major histocompatibility complex (MHC) of mammals. This study was undertaken to determine whether Hsp70 genes are linked to the MHC of Xenopus, an amphibian last sharing a common ancestor with mammals 300-350 million years ago. Segregation analyses involving seven haplotypes demonstrated the linkage of two or three inducible Hsp70 genes to the frog MHC. Another Hsp70 gene is not closely linke… Show more

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Cited by 51 publications
(22 citation statements)
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“…Doubleheaded arrows show that the order of the indicated loci is unknown and may be reversed. Note that the number of HSP70 genes may be two or three (15). coselection of alleles derived from the different loci (1,22).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Doubleheaded arrows show that the order of the indicated loci is unknown and may be reversed. Note that the number of HSP70 genes may be two or three (15). coselection of alleles derived from the different loci (1,22).…”
Section: Resultsmentioning
confidence: 99%
“…12) and C4 (13,14), heat shock protein 70 (HSP70; ref. 15), the proteasome element lmp7 (16), and RING3 (17) genes all map to the Xenopus MHC, demonstrating that the the same class I, II, and III components were genetically linked when amphibians and mammals diverged from an ancestor 300-350 million years ago (Fig. 1b).…”
mentioning
confidence: 99%
“…Other studies have demonstrated alterations in intracellular transport of class I molecules by mutations in the peptide-binding groove of HLA-A (22). The H63D mutation is localized in the ␣ 1 domain between the third and fourth ␤ strands of the external peptide-binding region.…”
Section: Hla-h Mutation Disrupts Protein Trafficking 14027mentioning
confidence: 99%
“…We began this study with BLASTn searches of X. tropicalis version 3.0 (estimated genomic coverage of 7.4ϫ) at the Department of Energy Joint Genome Institute (JGI; ͗www.jgi.doe.gov/xenopus͘) with MHC genes that were isolated over the past 10 years (class I (24), class II (25,26), TAP1 (10), TAP2 (27), PSMB8 (28), PSMB9 (29), Ring3 (30), C4 (31), Factor B (32), HSP70 (33), and RXRB (34,35)). In most cases, X. laevis genes were used for the searches because most genes were cloned from this species, and we were fortunate that usually there is enough sequence similarity in coding regions between X. laevis and X. tropicalis to permit isolation of the orthologues across species.…”
Section: Data-mining the X Tropicalis Genome Projectmentioning
confidence: 99%