HSP70 in the Immune Responses

Malyshev, I. Yu.

doi:10.1007/978-94-007-5943-5_5

Cited by 1 publication

(1 citation statement)

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“…HSP70s, for example, are implicated in the creation of antigen-dependent immunological memory in the case of microbial invasion, and in the establishment of antigen-independent immune memory in the case of other stressors. [80][81][82] Because HSP70 is involved in different ways in mechanisms that trigger an immune response, it is expected that HSP70 plays a significant role in neuroimmunological diseases, as well.…”

Section: Hsp70 In Neurodegeneration Diseasesmentioning

confidence: 99%

Impact of Heat Shock Proteins in Neurodegeneration: Possible Therapeutical Targets

Beretta

Shala

2022

Annals of Neurosciences

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Human neurodegenerative diseases occur as a result of various factors. Regardless of the variety in the etiology of development, many of these diseases are characterized by the accumulation of pathological, misfolded proteins; hence, such diseases are considered as proteinopathies. While plenty of research study has been conducted in order to identify the pathophysiology of these proteinopathies, there is still a lack of understanding in terms of potential therapeutic targets. Molecular chaperones present the main workforce for cellular protection and stress response. Therefore, considering these functions, molecular chaperones present a promising target for research within the field of conformational diseases that arise from proteinopathies. Since the association between neurodegenerative disorders and their long-term consequences is well documented, the need for the development of new therapeutic strategies becomes even more critical. In this review, we summarized the molecular function of heat shock proteins and recent progress on their role, involvement, and other mechanisms related to neurodegeneration caused by different etiological factors. Based on the relevant scientific data, we will highlight the functional classification of heat shock proteins, regulatin, and their therapeutic potential for neurodegenerative disorders.

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Section: Hsp70 In Neurodegeneration Diseasesmentioning

confidence: 99%