HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects

He, Xuegang; X, Guo; Deng, Bo; Kang, Jihe; Liu, Wenzhao; Zhang, Guangzhi; Wang, Yonggang; Yang, Yong; Kang, Xuewen

doi:10.1016/j.expneurol.2022.114301

Cited by 7 publications

(1 citation statement)

References 38 publications

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“…In fact, applied genetic research has shown that expression of the HSPA1A gene can be used to suppress mastitis in Chinese Holsteins [ 41 ]. HSPA1A has a neuroprotective effect on TSCI and may inhibit apoptosis by activating the Wnt/β-catenin signaling pathway [ 42 ]. The expression of HSPA1A varies significantly across different breeds and different Temperature–Humidity Index (THI) conditions.…”

Section: Discussionmentioning

confidence: 99%

Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance

Wang,

Yan,

et al. 2024

Animals

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Hainan yellow cattle are indigenous Zebu cattle from southern China known for their tolerance of heat and strong resistance to disease. Generations of adaptation to the tropical environment of southern China and decades of artificial breeding have left identifiable selection signals in their genomic makeup. However, information on the selection signatures of Hainan yellow cattle is scarce. Herein, we compared the genomes of Hainan yellow cattle with those of Zebu, Qinchuan, Nanyang, and Yanbian cattle breeds by the composite likelihood ratio method (CLR), Tajima’s D method, and identifying runs of homozygosity (ROHs), each of which may provide evidence of the genes responsible for heat tolerance in Hainan yellow cattle. The results showed that 5210, 1972, and 1290 single nucleotide polymorphisms (SNPs) were screened by the CLR method, Tajima’s D method, and ROH method, respectively. A total of 453, 450, and 325 genes, respectively, were identified near these SNPs. These genes were significantly enriched in 65 Gene Ontology (GO) functional terms and 11 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (corrected p < 0.05). Five genes—Adenosylhomocysteinase-like 2, DnaJ heat shock protein family (Hsp40) member C3, heat shock protein family A (Hsp70) member 1A, CD53 molecule, and zinc finger and BTB domain containing 12—were recognized as candidate genes associated with heat tolerance. After further functional verification of these genes, the research results may benefit the understanding of the genetic mechanism of the heat tolerance in Hainan yellow cattle, which lay the foundation for subsequent studies on heat stress in this breed.

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Section: Discussionmentioning

confidence: 99%

Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance

Wang,

Yan,

et al. 2024

Animals

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Effect of tannic acid on doxorubicin‐induced cellular stress: Expression levels of heat shock genes in rat spleen

Kizir,

Karaman,

Demir

et al. 2024

Biotech and App Biochem

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Doxorubicin (DOX), an anthracycline group antibiotic, has been extensively employed as a potent chemotherapeutic agent for treating solid and hematopoietic tumors in humans. Amid exposure to diverse stress conditions, living organisms swiftly initiate the synthesis of heat shock proteins (HSPs), a set of highly conserved proteins. Tannic acid (TA) has garnered increasing study attention due to its special chemical properties, health benefits, and wide availability. This study's primary aim is to elucidate the impact of DOX and TA on the expression levels of Hsp90aa1, Hspa1a, Hspa4, and Hspa5 in the spleen tissues of rats. Sprague Dawley rats (Rattus norvegicus, male, 9–10 weeks old, 180 ± 20 g) were randomly divided into 4 groups: control, DOX (30 mg/kg cumulative), TA (50 mg/kg), and DOX + TA (5 mg/kg and 50 mg/kg, respectively). Subsequently, spleen tissues were collected from rats, and complementary DNA libraries were generated after the application process. The quantitative real‐time PCR method was used to detect and quantify the mRNA expression changes of the Hsp90aa1, Hspa1a, Hspa4, and Hspa5 genes our results showed that the mRNA expressions of the targeted genes were up‐regulated in rat spleen tissues exposed to DOX. However, this increase was remarkably suppressed by TA treatment. These findings suggest that TA may serve as a protective agent, mitigating the toxic effects of DOX in the rat spleen.

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Crosstalk Between Cell Death and Spinal Cord Injury: Neurology and Therapy

Song,

Cui,

Sun

et al. 2024

Mol Neurobiol

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HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects

Cited by 7 publications

References 38 publications

Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance

Selection Signal Analysis Reveals Hainan Yellow Cattle Are Being Selectively Bred for Heat Tolerance

Effect of tannic acid on doxorubicin‐induced cellular stress: Expression levels of heat shock genes in rat spleen

Crosstalk Between Cell Death and Spinal Cord Injury: Neurology and Therapy

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