HSV-1 as well as HSV-2 is frequent in oral mucosal lesions of children on chemotherapy

Aggarwal, Ritu; Bansal, Deepak; Naru, Jasmine; Salaria, M; Rana, Anita; Minz, Ranjana Walker; Trehan, Amita; Marwaha, R. K.

doi:10.1007/s00520-014-2152-0

Cited by 19 publications

(20 citation statements)

References 28 publications

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“…However, Aggarwal et al [35] has confirmed a high (66%) prevalence of HSV-1 in oral mucositis in children receiving chemotherapy for cancer, but found no association of HSV-1 with mucositis severity. These authors believe that a relatively small sample size with a reasonably high prevalence of HSV could be the confounding factors for identifying such association.…”

Section: Discussionmentioning

confidence: 91%

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Mendonça

Araújo

Levy

et al. 2015

Pediatric Hematology and Oncology

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Section: Discussionmentioning

confidence: 91%

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Mendonça

Araújo

Levy

et al. 2015

Pediatric Hematology and Oncology

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“…It is plausible that specific herpesviruses are involved in oral carcinogenesis, through a hit and run mechanism, when affecting individuals with a specific genetic context. In particular, oral shedding HSV-2 has been previously reported (55,56) and changes in oral sexual behaviors (44, 45) could lead to an increasing incidence of oral infection by HSV-2 which is usually found in genital areas, but related evidence-based literature is scarce. Interestingly, HSV-2 infection has been described as more easily transmitted from men to women than from women to men (57), that would be in line with the increasing incidence of OSCC mostly observed in women, as discussed in the previous section.…”

Section: Viral Oncogenesis Of Oscc In Nsnd: Should We Incriminate Onlmentioning

confidence: 99%

Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

et al. 2020

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In some western countries, an increasing incidence of oral squamous cell carcinoma (OSCC) has been observed in non-smoker non-drinker patients (NSND), mostly in women with HPV-negative OSCC. In the context of the unknown etiology and mechanisms of tumorigenesis of OSCC in NSND, we discuss data supporting the hypothesis of a viral origin not related to HPV. OSCC from NSND are characterized by an antiviral DNA methylation and gene expression signature. Based on the similar increasing incidence of oral tongue SCC (OTSCC) and oropharyngeal SCC (OPSCC) in young women and men respectively, we hypothesize that changes in sexual behaviors may lead to an increasing incidence of herpesvirus in the oral cavity, especially HSV-2, similarly to what has already been described in HPV-positive OPSCC. Because viral genome integration has not been detected in OSCC from NSND, a "hit and run" viral mechanism involving epigenome deregulation could therefore play a key role at early steps of oral carcinogenesis in this population of patients. In conclusion, epidemiological, clinical and molecular data supports a "hit and run" viral origin of OSCC from NSND.

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“…Altogether, 2.2% of all the 1873 collected oral epithelial brush samples were HSV‐1 DNA positive . The shedding into saliva is expected to be more prevalent in immunocompromized patients or in patients with oral surgery …”

Section: Introductionmentioning

confidence: 99%

Herpes simplex and human papilloma virus coinfections in oral mucosa of men—A 6‐year follow‐up study

Mäki

Paavilainen

Kero

et al. 2017

Journal of Medical Virology

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Herpes simplex virus (HSV) establishes latency in neurons and recurrent infections in oral mucosa. This prospective study analyzes HSV prevalence in oral mucosal brush samples from men with known human papillomavirus (HPV) status. We hypothesized that HSV-1-infection could facilitate HPV persistence as a cofactor. This study was a part of the Finnish Family HPV study accomplished at the University of Turku/Turku University Hospital, Finland. A total of 139 men (mean age 28.6 ± 4.9 years) were enrolled at 36+-weeks of their partner's pregnancy and thereafter followed-up for 6 years. Altogether, 722 samples, extracted from oral brush samples collected at the enrollment timepoint (baseline) and at 2-, 6-, 12-, 24-, 36-month, and 6 years, were available. HSV DNA was analyzed with quantitative PCR. HSV-1 results were compared with the known HPV data. The prevalence of oral HSV-1 shedding varied between 0-7.2% (mean 2.8%) among the men. Mean copy numbers varied between 4 and 550 genome copies/sample. A total of 18 (12.9%) men were found HSV-1-positive at least once, two of them twice. Neither smoking nor oral sex was associated with the oral HSV-1-DNA finding. HPV/HSV-1 co-infection was found in 6 (4.3%) men, all of them having persistent HPV-infection. In conclusion, HSV-1 and its coinfection with HPV in oral mucosa was rare.

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HSV-1 as well as HSV-2 is frequent in oral mucosal lesions of children on chemotherapy

Abstract: Both HSV-1/2 are commonly shed from oral mucosal lesions in children receiving chemotherapy. In a novel finding, real-time PCR detected copies of HSV-2 in 69% cases, all missed by conventional PCR. Implication for morbidity, if any, or treatment needs to be determined.

Cited by 19 publications

References 28 publications

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

Herpes simplex and human papilloma virus coinfections in oral mucosa of men—A 6‐year follow‐up study

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