HSV-2 incidence by sex over four age periods to age 38 in a birth cohort: Table 1

Dickson, Nigel; Righarts, Antoinette; Roode, Thea van; Paul, Charlotte; Taylor, Janette; Cunningham, Anthony L.

doi:10.1136/sextrans-2013-051235

Cited by 13 publications

(8 citation statements)

References 8 publications

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“…Data on substance use/dependence, mental health and from the sexual health theme led by Nigel Dickson (e.g. [ 98 – 104 ]); also see [ 105 , 106 ]) have been used in a variety of New Zealand policy-making contexts (e.g. Health Select Committee reports, Law Commission reports, and a variety of professional bodies, e.g.…”

Section: Impact Beyond the Academymentioning

confidence: 99%

The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future

Poulton

Moffitt

Silva

2015

Soc Psychiatry Psychiatr Epidemiol

324

320

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The Dunedin Multidisciplinary Health and Development Study began more than four decades ago. Unusual at the time, it was founded as a multidisciplinary research enterprise, and was strongly supported by the Dunedin community, both professional and lay, in its early years. Seven research themes have evolved over the past 40 years focusing on mental health and neuro-cognition, cardiovascular risk, respiratory health, oral health, sexual and reproductive health, and psychosocial functioning. A seventh, more applied theme, seeks to maximise the value of the Study findings for New Zealand’s indigenous people—Māori (or tangata whenua transl people of the land). The study has published over 1200 papers and reports to date, with almost 2/3 of these being in peer-reviewed journals. Here we provide an overview of the study, its history, leadership structure, scientific approach, operational foci, and some recent examples of work that illustrate the following: (a) the value of multidisciplinary data; (b) how the study is well positioned to address contemporary issues; and (c) how research can simultaneously address multiple audiences—from researchers and theoreticians to policy makers and practitioners. Near-future research plans are described, and we end by reflecting upon the core aspects of the study that portend future useful contributions.

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Section: Impact Beyond the Academymentioning

confidence: 99%

The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future

Poulton

Moffitt

Silva

2015

Soc Psychiatry Psychiatr Epidemiol

324

320

View full text Add to dashboard Cite

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“…Noteworthy, the prevalence of HSV-2 infection is generally higher in women than in men with 50 % more cases occurring in the former group [54,57,65]. Although the reasons for these differences are unclear, it has been proposed that men might be more resistant to HSV-2 infection than women because of increased keratinization of the skin at the external surfaces of the genitalia.…”

Section: Incidence and Prevalence Of Hsv-2mentioning

confidence: 91%

“…The incidence of HSV-2 also varies greatly depending on the age of the individuals and is more pronounced once sexual activity is initiated. Currently, the highest infection rates in adults occur between ages 15 and 20 [54], although peak incidences at slightly higher ages are commonly observed in some populations [85].…”

Section: Incidence and Prevalence Of Hsv-2mentioning

confidence: 99%

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease

Suazo

Tognarelli

Kalergis

et al. 2014

Med Microbiol Immunol

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Infection with herpes simplex viruses is one of the most ancient diseases described to affect humans. Infection with these viruses produces vexing effects to the host, which frequently recur. Infection with herpes simplex viruses is lifelong, and currently there is no vaccine or drug to prevent or cure infection. Prevalence of herpes simplex virus 2 (HSV-2) infection varies significantly depending on the geographical region and nears 20% worldwide. Importantly, HSV-2 is the first cause of genital ulcers in the planet. HSV-2 affects approximately 500 million people around the globe and significantly increases the likelihood of acquiring the human immunodeficiency virus (HIV), as well as its shedding. Thus, controlling HSV-2 infection and spread is of public health concern. Here, we review the diseases produced by herpes simplex viruses, the factors that modulate HSV-2 infection, the relationship between HSV-2 and HIV and novel therapeutic and prophylactic microbicides/antivirals under development to prevent infection and pathological outcomes produced by this virus. We also review mutations associated with HSV-2 resistance to common antivirals.

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“…Herpesviruses are frequently found in humans, although their prevalence significantly varies depending on ethnicity, sex, and geographical location of individuals, among others [ 1 – 5 ]. Currently, eight Herpesviridae family members are known to infect humans: herpes simplex viruses (HSV) -1 and -2 (HSV-1, HHV-1 and HSV-2, HHV-2, resp.…”

Section: Introductionmentioning

confidence: 99%

Evasion of Early Antiviral Responses by Herpes Simplex Viruses

Suazo

Ibáñez

Retamal-Díaz

et al. 2015

Mediators of Inflammation

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Besides overcoming physical constraints, such as extreme temperatures, reduced humidity, elevated pressure, and natural predators, human pathogens further need to overcome an arsenal of antimicrobial components evolved by the host to limit infection, replication and optimally, reinfection. Herpes simplex virus-1 (HSV-1) and herpes simplex virus-2 (HSV-2) infect humans at a high frequency and persist within the host for life by establishing latency in neurons. To gain access to these cells, herpes simplex viruses (HSVs) must replicate and block immediate host antiviral responses elicited by epithelial cells and innate immune components early after infection. During these processes, infected and noninfected neighboring cells, as well as tissue-resident and patrolling immune cells, will sense viral components and cell-associated danger signals and secrete soluble mediators. While type-I interferons aim at limiting virus spread, cytokines and chemokines will modulate resident and incoming immune cells. In this paper, we discuss recent findings relative to the early steps taking place during HSV infection and replication. Further, we discuss how HSVs evade detection by host cells and the molecular mechanisms evolved by these viruses to circumvent early antiviral mechanisms, ultimately leading to neuron infection and the establishment of latency.

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HSV-2 incidence by sex over four age periods to age 38 in a birth cohort: Table 1

Cited by 13 publications

References 8 publications

The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future

The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future

Herpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease

Evasion of Early Antiviral Responses by Herpes Simplex Viruses

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