Endocrine and Neural Senescence overlap by intertwined complex
feedback loops. The variable levels of estradiol, progesterone,
DHEA(S), and neurotransmitters -GABA, serotonin, dopamine
and glutamate dependent on sexual steroids make women’s brain
to suffer from the menarche to menopause, perimenopause being
a “critical period”, “a neurological transition state” offering to the
scientific and medical communities a “window of opportunity” to
delay the onset of brain aging, The modern medical communities
are moving from focusing on the treatment of already identified
dementia to develop strategies for accurate depiction of predementia
conditions/risk factors for brain aging, for prevention and slowing
a demented status to progress from early stages of endocrine aging
process [1].