“…It generates cost saving through informing reimbursement and disinvestment decisions, which in the long-term improves technical, and allocative efficiency, as well as strategic pricing. HTA can contribute to budget control to ensure fiscal sustainability (Al-Aqeel, 2018;Angelis, 2018;Beletsi, 2018;Borges, 2018;Callea, 2017;Castro, 2018;Dabak, 2019;Dang, 2016;Epstein, 2020;Gagnon, 2014;Guthrie, 2015;Hailey, 2016;Hasegawa, 2020;Kanavos, 2019;Kido, 2019;Leelahavarong, 2019;Mahlich, 2017;Miquel-Cases, 2017;Nestler-Parr, 2018;Pearce, 2019;Schuller, 2017;Schumacher, 2013;Surgey, 2020;Tanvejsilp, 2019;Van Wilder, 2019;Vostalová, 2017;Yazdizadeh, 2018). • HTA improves pharmaceutical pricing, specially it ensures better value for money of orphan drugs (Kogushi, 2020;Mägi, 2018;Nestler-Parr, 2018;Roza, 2019;Vo, 2018).…”