hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells

Papanikolaou, Vassilis; Athanassiou, Evangelos; Dubos, Stephanie; Dimou, Ioannis; Papathanasiou, Ioanna V.; Kitsiou-Tzeli, Sofia; Kappas, Constantin; Tsezou, Aspasia

doi:10.3109/09553002.2011.572112

Cited by 19 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, some of these effects seem to rely on nontelomeric activities of TERT. Furthermore, a similar mechanism has also been reported in breast cancer cell lines (Papanikolaou et al, 2011). Finally, telomerase can also regulate NF-κB activity through direct interaction with p65 to promote transcription of a NF-κB target gene subset, demonstrating the existence of a feed-forward mechanism between NF-κB and telomerase at least in cancer cells .…”

Section: Nf-κb and Telomeressupporting

confidence: 66%

NF-κB signaling as a driver of ageing

Osorio

Soria‐Valles

Santiago‐Fernández

et al. 2016

International Review of Cell and Molecular Biology

View full text Add to dashboard Cite

Section: Nf-κb and Telomeressupporting

confidence: 66%

NF-κB signaling as a driver of ageing

Osorio

Soria‐Valles

Santiago‐Fernández

et al. 2016

International Review of Cell and Molecular Biology

View full text Add to dashboard Cite

“…They showed a relationship between the HER2 receptor and hTERT involving NF-B signalling for increased radio-resistance in breast cancer [80]. The authors demonstrated that the HER2 receptor could be a functional transcriptional regulator of hTERT expression through NF-B and the myc/mad/max network in breast cancer cells after irradiation.…”

Section: Interaction Of Telomerase and Nf-b For In-flammation And Canmentioning

confidence: 98%

Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress

Saretzki

2014

CPD

135

104

View full text Add to dashboard Cite

Telomerase activity is essential for human cancer cells in order to maintain telomeres and provide unlimited proliferation potential and cellular immortality. However, additional non-telomeric roles emerge for the telomerase protein TERT that can impact tumourigenesis and cancer cell properties. This review summarises our current knowledge of non-telomeric functions of telomerase in human cells, with a special emphasis on cancer cells. Non-canonical functions of telomerase can be performed within the nucleus as well as in other cellular compartments. These telomereindependent activities of TERT influence various essential cellular processes, such as gene expression, signalling pathways, mitochondrial function as well as cell survival and stress resistance. Emerging data show the interaction of telomerase with intracellular signalling pathways such as NF-κB and WNT/β-catenin; thereby contributing to inflammation, epithelial to mesenchymal transition (EMT) and cancer invasiveness. All these different functions might contribute to tumourigenesis, and have serious consequences for cancer therapies due to increased resistance against damaging agents and prevention of cell death. In addition, TERT has been detected in non-nuclear locations such as the cytoplasm and mitochondria. Within mitochondria TERT has been shown to decrease ROS generation, improve respiration, bind to mitochondrial DNA, increase mitochondrial membrane potential and interact with mitochondrial tRNAs. All these different non-telomere-related mechanisms might contribute towards the higher resistance of cancer cells against DNA damaging treatments and promote cellular survival. Understanding these different mechanisms and their complexity in cancer cells might help to design more effective cancer therapies in the future.

show abstract

“…Sequential induction of Nuclear Factor-kappa B (NF-κB) and c-Myc has been suggested to aid human epidermal growth factor receptor 2 (HER2) in the activation of hTERT following irradiation (Papanikolaou et al, 2011). It was determined that the knockdown of HER2 led to the down-regulation of NF-κB and c-Myc-mediated hTERT and telomerase activity in human breast cancer cells (Papanikolaou et al, 2011). Deng et al (2007) identified the activating enhancer binding protein-2β (AP-2β) as a unique transcriptional activator of hTERT in human lung cancer cells.…”

Section: The Htert Promoter and Associated Transcription Factorsmentioning

confidence: 99%

Regulation of the human catalytic subunit of telomerase (hTERT)

Daniel

Peek

Tollefsbol

2012

Gene

245

230

View full text Add to dashboard Cite

Over the past decade, there has been much interest in the regulation of telomerase, the enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in cellular immortalization, tumorigenesis, and the progression of cancer. Telomerase activity is characterized by the expression of the telomerase reverse transcriptase (TERT) gene, suggesting that TERT serves as the major limiting agent for telomerase activity. Recent discoveries have led to characterization of various interactants that aid in the regulation of human TERT (hTERT), including numerous transcription factors; further supporting the pivotal role that transcription plays in both the expression and repression of telomerase. Several studies have suggested that epigenetic modulation of the hTERT core promoter region may provide an additional level of regulation. Although these studies have provided essential information on the regulation of hTERT, there has been ambiguity of the role of methylation within the core promoter region and the subsequent binding of various activating and repressive agents. As a result, we found it necessary to consolidate and summarize these recent developments and elucidate these discrepancies. In this review, we focus on the co-regulation of hTERT via transcriptional regulation, the presence or absence of various activators and repressors, as well as the epigenetic pathways of DNA methylation and histone modifications.

show abstract

hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells

Abstract: The present study suggests that following irradiation, HER2 receptor activates hTERT/telomerase, increasing the breast cancer cells' survival potential, through sequential induction of transcription factors NF-κΒ and c-myc.

Cited by 19 publications

References 19 publications

NF-κB signaling as a driver of ageing

NF-κB signaling as a driver of ageing

Extra-telomeric Functions of Human Telomerase: Cancer, Mitochondria and Oxidative Stress

Regulation of the human catalytic subunit of telomerase (hTERT)

Contact Info

Product

Resources

About