HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II-infected blood donors

Murphy, Edward L.; Fridey, Joy; Smith, James W.; Engstrom, John W.; Sacher, Ronald A.; Miller, Kurt W.; Gibble, Joan; Stevens, J. M.; Thomson, Ruth; Hansma, D.; Kaplan, Jonathan E.; Khabbaz, Rima F.; Nemo, George J.

doi:10.1212/wnl.48.2.315

Cited by 121 publications

(79 citation statements)

References 17 publications

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“…16 The relationship between HTLV-2 and neurological and systemic diseases is less well defined, although it appears that it is less frequent and less severe. [17][18][19][20] Syndromes that are part of the neurological complex related to HTLV-1 have a distinct pathogenic substrate from adult T-cell leukemia/lymphoma (ATL). 2 It is also not entirely clear how HTLV resists a competent immune system or what determines risk of development of the diseases associated with it.…”

Section: Transmissionmentioning

confidence: 99%

O vírus linfotrópico de células T humanos tipo 1 (HTLV-1): Quando suspeitar da infecção?

Romanelli¹,

Caramelli²,

Proietti³

2010

Rev. Assoc. Med. Bras.

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Section: Transmissionmentioning

confidence: 99%

O vírus linfotrópico de células T humanos tipo 1 (HTLV-1): Quando suspeitar da infecção?

Romanelli¹,

Caramelli²,

Proietti³

2010

Rev. Assoc. Med. Bras.

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“…It has also been associated with a variety of other syndromes, including infectious dermatitis in children (Lagrenade et al, 1990) and uveitis (Mochizuki et al, 1992), and to a lesser extent with arthropathy (Ijichi et al, 1990) and polymyositis (Morgan et al, 1989). HTLV-II may be responsible for neurological syndromes that are clinically similar to TSP/ HAM (Hjelle et al, 1992;Murphy et al, 1997), but no hematological disorders have been definitely linked to infection with this virus (Fouchard et al, 1995;Hjelle et al, 1991).…”

Section: Human T-cell Lymphotropic Viruses Types I (Htlv-i) and Typementioning

confidence: 99%

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology

Kazanji

Gessain

2003

Cad. Saúde Pública

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We review here the epidemiological studies performed by our group on human retrovirus HTLV-I and HTLV-II infections and the associated diseases in French Guiana since 1984. French Guiana is an overseas French administrative district located between Key words Retroviridae; HTLV-I; HTLV-II; Genetic Variability; T-cell Leukemia Resumo Os autores apresentam uma revisão dos estudos epidemiológicos realizados pelo seu grupo de pesquisa sobre a infecção pelos vírus T-linfotrópicos humanos tipo I (HTLV-I) e tipo II (HTLV-II) e doenças associadas na Guiana Francesa, desde 1984. A Guiana Francesa é um

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“…However, 1 in every 1000-2000 individuals with positive serology per year develop adult T-cell leukemia/lymphoma (ATLL) (Poiesz et al, 1980;Tajima, 1990) and other patients may present with myelopathy (HAM) (Gessain et al, 1985). The prevalence of the latter has been estimated to be 2.4% in the United States (Murphy et al, 1997) but only about 0.07% among the Japanese (Osame et al, 1990). Several genetic aspects, viral or human, have been tested as possible determinants of clinical course of the HTLV-I infection.…”

Section: Introductionmentioning

confidence: 99%

Frequency of the CCRdelta32 allele in Brazilians: a study in colorectal cancer and in HTLV-I infection

et al. 2000

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The identification of a 32-bp deletion in the cc-chemokine receptor-5 gene (CCR5delta32 allele) that renders homozygous individuals highly resistant to HIV infection has prompted worldwide investigations of the frequency of the CCR5delta32 allele in regional populations. It is important to ascertain if CCR5delta32 is a factor to be considered in the overall epidemiology of HIV in individual populations. With this in mind we determined the CCR5delta32 allele frequency in a large sample (907 individuals) of the southeastern Brazilian urban population, stratified as follows: 322 healthy unrelated individuals, 354 unselected colorectal cancer patients, and 229 blood donors. The three groups displayed essentially identical allelic frequencies of CCR5delta32 and pairwise comparisons did not show significant differences. Thus, our results can be pooled to provide a reliable estimate of the CCR5delta32 allele frequency in the southeastern Brazil of 0.053 ± 0.005. The blood donors comprised 50 HTLV-I serologically negative individuals, 115 non-symptomatic individuals HTLV-I positive by ELISA but with indeterminate Western blot results, 49 healthy blood donors HTLV-I positive both at ELISA and Western blot and 15 patients with clinical spinal cord disease (HAM). A suggestive trend was observed, with the CCR5delta32 frequencies decreasing progressively in these four categories. However, when we applied Fischer's exact test no significant differences emerged. We believe that further studies in larger cohorts should be performed to ascertain whether the CCR5delta32 allele influences the chance of becoming infected or developing clinical symptoms of HTLV-I infection.
A observação de que indivíduos homozigotos para uma deleção de 32 pares de base no gene que codifica para o receptor 5 de cc-quimiocinas apresentam um menor risco de contrair a infecção por HIV-1 levou à investigação da freqüência deste polimorfismo em várias populações mundiais. É importante investigar se o CCR5delta32 é um fator a ser considerado na epidemiologia do HIV em populações individuais. Com estes pressupostos em mente nós estabelecemos a freqüência do CCR5delta32 em uma grande amostra (907 indivíduos não-relacionados) da população urbana do sudeste brasileiro, estratificada da seguinte maneira: 322 indivíduos sadios, 354 pacientes com câncer colorretal e 229 doadores de sangue. Os três grupos apresentaram essencialmente a mesma freqüência alélica de CCR5delta32 e a comparação par-a-par não revelou diferenças significativas. Assim, os nossos resultados podem ser agrupados para fornecer uma estimativa confiável de 0,053 ± 0,005 da freqüência alélica de CCR5delta32. Os doadores de sangue compreendiam 50 indivíduos soronegativos para HTLV-I, 115 indivíduos assintomáticos por ELISA mas com resultados indeterminados em Western blot, 49 indivíduos soropositivos para HTLV-I mas assintomáticos e 15 indivíduos soropositivos para HTLV-I sintomáticos com mielopatia. Foi observado um sugestivo gradiente decrescente da freqüência alélica de CCR5delta32 nestas cat...

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HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II-infected blood donors

Cited by 121 publications

References 17 publications

O vírus linfotrópico de células T humanos tipo 1 (HTLV-1): Quando suspeitar da infecção?

O vírus linfotrópico de células T humanos tipo 1 (HTLV-1): Quando suspeitar da infecção?

Human T-cell Lymphotropic Virus types I and II (HTLV-I/II) in French Guiana: clinical and molecular epidemiology

Frequency of the CCRdelta32 allele in Brazilians: a study in colorectal cancer and in HTLV-I infection

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