HTLV-I and HTLV-Iii Antibodies and Tropical Spastic Paraparesis

Rodgers‐Johnson, Pamela; Gajdusek, D. Carleton; Morgan, Owen; Zaninovic, Vladimir; Sarin, P. S.; Graham, DanielS.

doi:10.1016/s0140-6736(85)90778-0

Cited by 259 publications

(79 citation statements)

References 3 publications

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“…Human T-cell lymphotropic virus type-1 (HTLV-1) is the etiologic agent of both adult T-cell leukemia (ATL) (Hinuma et al, 1981;Poiesz et al, 1981;Yoshida et al, 1982) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) (Gessain et al, 1985;Osame et al, 1986;Rodgers-Johnson et al, 1985). HAM/TSP is a chronic inflammatory disorder, predominantly affecting the brain and spinal cord, and characterized by weakness, spasticity of the lower extremities, urinary incontinence, and hyperreflexia .…”

Section: Introductionmentioning

confidence: 99%

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Johnson-Nauroth¹,

Graber²,

Yao³

et al. 2006

Journal of Neuroimmunology

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Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA − /CCR7 − T EM and CD45RA + /CCR7 − T Diff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Rα, failed to respond to IL-7 and IL-15, and did not develop a T CM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of T EM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.

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Section: Introductionmentioning

confidence: 99%

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Johnson-Nauroth¹,

Graber²,

Yao³

et al. 2006

Journal of Neuroimmunology

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“…Human T-cell leukemia/lymphotropic virus type I (HTLV-I) (1,2) is the causative agent of adult T-cell leukemia (ATL) (3)(4)(5) and a progressive myelopathy designated tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/ HAM) (6)(7)(8). The 3' end of the HTLV-I genome, originally called pX (9), carries at least four open reading frames (orf I-orf IV).…”

mentioning

confidence: 99%

Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I.

Koralnik

Gessain

Klotman

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

178

218

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“…These observations suggest that HTLV-I may play a role in the generation of autoimmune diseases. Autoimmune diseases, such as myelopathy (HAM/TSP) [7,8], arthropathy (HAAP) [9,10], and bronchoalveolitis (HAB) [11], have been found in HTLV-I carriers, termed 'HTLV-I-associated syndrome' [12]. Recently the seroprevalance in patients having uveitis without defined etiologies was found significantly higher than that in patients with non-uveitic ocular diseases or in patients having uveitis with defined etiologies [13].…”

Section: Introductionmentioning

confidence: 99%

Antigenic cross-reactivity between human T lymphotropic virus type I (HTLV-I) and retinal antigens recognized by T cells

Fukushima

Ueno

Fujimoto

1994

Clinical and Experimental Immunology

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SUMMARY To investigate the relationship between uveitis and HTLV‐I infection, we examined the crossreactivity between HTLV‐I antigens and retinal antigens recognized by T cells in BIO.BR mice immunized with human HTLV‐I‐infected MT‐2 cells. We found that T cells obtained from MT‐2 immune mouse spleen responded not only to HTLV‐I antigens but also to retinal antigens of various species. However, they did not respond to HTLV‐I‐negative lymphoid cell lines. Furthermore, established T cell lines from MT‐2 immune spleen cells also responded to both HTLV‐I and retinal antigens. The phenotype of the immune cells that responded to both HTLV‐I and retinal antigens was CD4+, CD8‐, and CD3+. The proliferative response of T cell lines to HTLV‐I as well as various retinal antigens, was clearly blocked by addition of anti‐CD3, anti‐CD4, or anti‐I‐AK MoAbs, but not by anti‐CD8 antibody. The established T cell lines from HTLV‐I immune spleen cells were all found to be CD3+, TCRβ+, CD4+, CD8‐ cells by flow cytometric analysis. These results indicate that an epitope of HTLV‐I antigens is cross‐reactive to an epitope of retinal antigens extracted from either human retinoblastoma or normal murine, rat, and bovine retinae at a T cell recognition level.

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HTLV-I and HTLV-Iii Antibodies and Tropical Spastic Paraparesis

Cited by 259 publications

References 3 publications

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I.

Antigenic cross-reactivity between human T lymphotropic virus type I (HTLV-I) and retinal antigens recognized by T cells

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