Huang-Lian-Jie-Du decoction attenuates cognitive dysfunction of rats with type 2 diabetes by regulating autophagy and NLRP3 inflammasome activation

Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO‐1 signaling, the microbiota‐gut‐brain axis, and hippocampal neuron ferroptosis

“…After 8 weeks, rats were euthanized after behavioral tests. The drug was administered at 9 a.m. (Tian et al, 2022). Fasting blood glucose was measured every 2 weeks.…”

Inflammasomes as potential mediators of adverse cardiovascular events in diabetes and lupus: more questions than answers

“…NLRP3 inflammasomeinduced IL-1b production plays an important role in the development of obesity and diabetes Wan et al 24 NLRP3 expression levels in diabetic patients provide novel insights into pathological mechanisms of diabetic atherosclerosis and have potential therapeutic implications for cardiovascular complications in diabetes Kim et al 25 SGLT2 inhibitor treatment in patients with T2DM at a high risk of CVD attenuates NLRP3 inflammasome activation and secretion of IL-1b, which has a pathogenic effect on both T2D and CVD, in part via increased serum b-hydroxybutyrate and decreased serum insulin, glucose and uric acid Liu et al 26 miR-17-5p improves glucose tolerance, and pancreatic b-cell function and inhibits TXNIP/NLRP3 inflammasome pathway-related pyroptosis in DM mice Zhang et al 27 Urolithin A is a potential antipancreatic inflammation agent that activates AMPK and autophagy to inhibit endoplasmic reticulum stress associated TXNIP/NLRP3/IL-1b signal pathway Sun et al 28 NLRP3 inflammasome is highly involved in the pathogenesis and progression of diabetic cardiomyopathy (DCM). Targeting the NLRP3 inflammasome pathway in DCM is a potential therapeutic approach to manage the disease Tian et al 29 The neuroprotective effect is exerted via the modulation of glucose and lipid metabolism, upregulation of autophagy and inhibition of NLRP3 inflammasome signalling pathway Zhang et al 30 Tetramethylpyrazine ameliorates diabetes-induced high platelet response and endothelial adhesion via inhibiting NLRP3 inflammasome activation in T2DM rats, which provide a new basis for the clinical prevention and treatment of diabetes-associated cardiovascular events Ozbayer et al 31 The rs10925027 CC genotype, rs4925659 GG genotype, rs10754558 GG and GCþGG genotypes of the NLRP3 were determined as important risk factors for the T2DM…”

“…For example, new data have suggested that not only NLRP3 inflammasomes might be considered as potential interventions to deplete hyperglycemic toxicity and avert the onset of vascular complications in T2DM, but also T2DM as an inflammatory disease stimulated by pro-inflammatory cytokines might be involved in NLRP3 inflammasome activation leading to endothelial dysfunction 22 . As seen in Table 1, 22–31 a series of studies show this potential intimate relationship between diabetes mellitus and NLRP3 inflammasomes. However, additional studies are needed to close current gaps in understanding to better comprehend the interaction between NLRP3 inflammasomes and diseases.…”

Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment

“…Huang-Lian-Jie-Du formulae (HLJDD) is a traditional Chinese formula, which has been used in diabetes and Alzheimer’s disease for a long time. HLJDD has been shown to take neuroprotective effects through regulation of glucose and lipid metabolism, up-regulation of autophagy and inhibition of NLRP3 inflammasome signaling pathways ( 145 ) ( Table 2 ).…”