Huanglian Jiedu plaster ameliorated X-ray-induced radiation dermatitis injury by inhibiting HMGB1-mediated macrophage-inflammatory interaction

Wang, Jie; Xie, Ke-huan; Ren, Wei; Han, Rang-Yue; Xiao, Le; Yu, Jie; Tan, Ruizhi; Wang, Li; Liao, Da-zhong

doi:10.1016/j.jep.2022.115917

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Previous studies have elucidated that HJD has shown potential acting as enteral nutrition in septic patients [10], treating diabetes by increasing activity of intestinal pancreatic lipase [11], and intervening gastrointestinal dysfunction [12] in clinical practices. In addition to the clinical use, HJD was believed to have the ability in ameliorating inflammatory in DSS-induced colitis [13], X-ray-induced radiation dermatitis injury [14], kidney injury [15], cardio injury [16], and atopic dermatitis [17] in mice. Furthermore, it could remodel the periphery microenvironment to inhibit Alzheimer's disease in mice [18].…”

Section: Introductionmentioning

confidence: 99%

Unraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation

Xie,

Gong,

Wang

et al. 2024

BMC Complement Med Ther

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Huanglian Jiedu Decoction (HJD) is a well-known Traditional Chinese Medicine formula that has been used for liver protection in thousands of years. However, the therapeutic effects and mechanisms of HJD in treating drug-induced liver injury (DILI) remain unknown. In this study, a total of 26 genes related to both HJD and DILI were identified, which are corresponding to a total of 41 potential active compounds in HJD. KEGG analysis revealed that Tryptophan metabolism pathway is particularly important. The overlapped genes from KEGG and GO analysis indicated the significance of CYP1A1, CYP1A2, and CYP1B1. Experimental results confirmed that HJD has a protective effect on DILI through Tryptophan metabolism pathway. In addition, the active ingredients Corymbosin, and Moslosooflavone were found to have relative strong intensity in UPLC-Q-TOF-MS/MS analysis, showing interactions with CYP1A1, CYP1A2, and CYP1B1 through molecule docking. These findings could provide insights into the treatment effects of HJD on DILI.

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Section: Introductionmentioning

confidence: 99%

Unraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation

Xie,

Gong,

Wang

et al. 2024

BMC Complement Med Ther

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Prevention and treatment of radiation injury by traditional Chinese medicine: A review

He,

Edi,

et al. 2024

Chinese Herbal Medicines

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Traditional Chinese medicine: an important coping strategy with challenges of radiation injury

Shao,

Gao

2024

Acupuncture and Herbal Medicine

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People turn nervous when mention is made of radiation injuries, which cause multiple organ morbidities and are difficult to manage. However, the discovery of antiradiation drugs remains challenging. Traditional Chinese medicine (TCM) may be an effective treatment strategy because of its overall regulation. Herein, we systematically review TCM formulae, herbs, and natural products as potential antiradiation candidates. At the same time, we categorize them by their effective characteristics and target organs. In addition, TCM formulae, herbs, and ingredients used to block the absorption and accelerate the excretion of radionuclides are considered in this review. To better manage radiation injuries, the scientific basis of TCM for radioprotection requires further in-depth research.

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Huanglian Jiedu plaster ameliorated X-ray-induced radiation dermatitis injury by inhibiting HMGB1-mediated macrophage-inflammatory interaction

Cited by 4 publications

References 30 publications

Unraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation

Unraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation

Prevention and treatment of radiation injury by traditional Chinese medicine: A review

Traditional Chinese medicine: an important coping strategy with challenges of radiation injury

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